Explanipedia

Integrative Spatial and Single-Nucleus Transcriptomics Elucidate Cell Lineage Dynamics in Human Tooth Morphogenesis Open

Xiaohang Chen, Gaochi Li, Jian Zhang, Fei He, Zihan Yang , et al. · 2025

GDF-15 as a biomarker for diagnosis and prognosis of lung cancer: a meta-analysis Open

Teng Pan, Rui Duan, Zihan Xu, Xiaohan He, Xiaojin Luo , et al. · 2025

Introduction Due to the tendency of lung cancer to be diagnosed at advanced stages, many patients are not eligible for curative surgery. Identifying early detection and prognosis biomarkers is crucial for improving outcomes. This study exp…

Detection of a novel large fragment deletion in the alpha-globin gene cluster using the CNVplex technology Open

Jianfei Xu, Liang Hu, Lijuan Wen, Xianzhen Cao, Hong‐Yan Xu , et al. · 2025

Objective To describe the characterization of a novel deletion causing α-thalassemia. Methods The proband was a 4-year-old boy who presented with abnormal hematological parameters identified during routine blood investigation conducted for…

Evidence linking phthalate exposure to alterations of hematologic parameters in Chinese children: A cross-sectional study Open

Maoti Wei, Ying Wen, Zhuxia Zhang, Xiuju Liu, Fengxiang Wei , et al. · 2025

School-aged children are a particularly susceptible population to phthalate exposure, yet research examining the correlation between combined exposure to multiple phthalates and hematologic changes is limited. We explored the individual an…

Fetal intracranial hemorrhage in second trimester: An ominous finding even after a normal array Open

YUN LONG, Siqi Wu, Xin Wang, Liping Wu, Yimin Xiong , et al. · 2025

This case underscores the importance of image-assisted examinations such as prenatal ultrasound and MRI, and that WES is a critical tool to establish the genetic etiology.

Detection of the Prognostic Gene CYB5D2 in Cervical Squamous Epithelial Lesions Open

Y. Liu, Guoqiang Zhao, Yanqing Kong, Fengyuan Zhou, Tong Zhang , et al. · 2025

CYB5D2 is a novel tumor suppressor gene that exhibits ectopic expression in various tumors. This study explored its significance in cervical cancer screening and prognosis by examining its expression in cervical precancerous lesions and ca…

Genetic etiology and phenotypic characteristics of fetuses with 11q deletion (11q23.3-q25) syndrome Open

Tong Zhang, Xiaoyi Cong, Zhenming Li, Xianzhen Cao, Liang Hu , et al. · 2024

Objective: To investigate the clinical phenotype, genetic etiology, and diagnosis of 11q deletion (11q-) syndrome. Methods: In this study, pregnant women were selected from prenatal testing in Longgang Maternal and Child Health Hospital of…

A prospective multicenter birth cohort in China: pregnancy health atlas Open

Si Zhou, Niya Zhou, Hanbo Zhang, Wenzhi Yang, Qingsong Liu , et al. · 2024

HPV16 E6-induced M2 macrophage polarization in the cervical microenvironment via exosomal miR-204-5p Open

Xiaohang Chen, Yanan Liu, Xiaojin Luo, Teng Pan, Tong Zhang , et al. · 2024

The persistent infection of high-risk human papillomavirus (HPV) and the progression of cervical cancer necessitate the involvement of microenvironmental immunity. As cervical lesions advance, there is an observed increase in the infiltrat…

Genome-wide association study of maternal plasma metabolites during pregnancy Open

Siyang Liu, Jilong Yao, Liang Lin, Xianmei Lan, Linlin Wu , et al. · 2024

Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies Open

Yuandan Wei, Jianxin Zhen, Liang Hu, Yuqin Gu, Yanhong Liu , et al. · 2024

Maintaining normal thyroid function is crucial in pregnancy, yet thyroid dysfunction and the presence of thyroid peroxidase antibodies (TPOAb) affect 0.5% to 18% of pregnant women. Here, we conducted a genome-wide association study (GWAS) …

The MondoA-dependent TXNIP/GDF15 axis predicts oxaliplatin response in colorectal adenocarcinomas Open

Jinhai Deng, Teng Pan, Dan Wang, Yourae Hong, Zaoqu Liu , et al. · 2024

Chemotherapy, the standard of care treatment for cancer patients with advanced disease, has been increasingly recognized to activate host immune responses to produce durable outcomes. Here, in colorectal adenocarcinoma (CRC) we identify ox…

Genetic study of intrahepatic cholestasis of pregnancy in 101,023 Chinese women unveils East Asian-specific etiology linked to historic HBV infection Open

Yanhong Liu, Yuandan Wei, Xiaohang Chen, Shujia Huang, Yuqin Gu , et al. · 2024

Background & Aims Intrahepatic cholestasis of pregnancy (ICP) is the most common and high-risk liver disorder during the critical period of human reproduction. Despite varying prevalence across populations, a mechanistic understanding of t…

Prenatal Genetic Detection and Clinical Characteristics of Fetuses with Mosaic Trisomy 2 Open

Tong Zhang, Xiaoyi Cong, Xianzhen Cao, Yanan Liu, Liang Hu , et al. · 2024

Objective: To evaluate the clinical characteristics, pregnancy outcomes, and sensitivity of different prenatal diagnosis methods in four prenatal cases of mosaic trisomy 2. Methods: From November 2022 to March 2024, three fetuses and one a…

Editorial: Advances in research on aging in female infertility and pathologic pregnancy Open

Bin Liu, Gendie E. Lash, Fengxiang Wei, Priyadarshini Pantham · 2024

Keywords: advanced age, female infertility, pathological pregnancy, ovarian diseases, peripheral index

Randomized controlled trial comparing the impacts of Saccharomyces boulardii and Lactobacillus rhamnosus OF44 on intestinal flora in cerebral palsy rats: insights into inflammation biomarkers and depression-like behaviors Open

Chunuo Chu, Shang Huang, Xin Wang, Guo-qiang Zhao, Wenqi Hao , et al. · 2024

Our results indicated that L. rhamnosus OF44 has potential in alleviating inflammation and altering the gut microbial composition in CP, and that it has the potential to clinically treat CP. There are some limitations of this study.…

Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia Open

Zijing Yang, Liang Hu, Jianxin Zhen, Yuqin Gu, Yanhong Liu , et al. · 2023

Platelet count reduction occurs throughout pregnancy, with 5% to 12% of pregnant women being diagnosed with gestational thrombocytopenia (GT), characterized by a more marked decrease in platelet count during pregnancy. However, the underly…

Multi-trait genome-wide association study in 34,394 Chinese women reveals the genetic architecture of plasma metabolites during pregnancy Open

Siyang Liu, Jilong Yao, Liang Lin, Xianmei Lan, Linlin Wu , et al. · 2023

Summary Metabolites are important indicators of individual health and can serve as crucial targets for therapy. However, the genetic basis of many metabolites remains largely unexplored, especially among underrepresented East Asians and du…

Taxifolin Inhibits the Growth of Non-Small-Cell Lung Cancer via Downregulating Genes Displaying Novel and Robust Associations with Immune Evasion Factors Open

Xiaozeng Lin, Ying Dong, Yan Gu, Fengxiang Wei, Jingyi Peng , et al. · 2023

Using an LL2 cell-based syngeneic mouse LC model, taxifolin suppressed allografts along with the appearance of 578 differentially expressed genes (DEGs). These DEGs were associated with enhancement of processes related to the extracellular…

Chromosome instability region analysis and identification of the driver genes of the epithelial ovarian cancer cell lines <span>A2780</span> and <span>SKOV3</span> Open

Jianxiong Li, Ze-xin Chase Chen, Wentao Xiao, Huaguo Liang, Yanan Liu , et al. · 2023

Epithelial ovarian cancer (EOC) is one of the most prevalent gynaecological cancers worldwide. The molecular mechanisms of serous ovarian cancer (SOC) remain unclear and not well understood. SOC cases are primarily diagnosed at the late st…

Taxifolin Inhibits Breast Cancer Growth by Facilitating CD8+ T Cell Infiltration and Inducing a Novel Set of Genes including Potential Tumor Suppressor Genes in 1q21.3 Open

Xiaozeng Lin, Ying Dong, Yan Gu, Anil Kapoor, Jingyi Peng , et al. · 2023

Taxifolin inhibits breast cancer (BC) via novel mechanisms. In a syngeneic mouse BC model, taxifolin suppressed 4T-1 cell-derived allografts. RNA-seq of 4T-1 tumors identified 36 differentially expressed genes (DEGs) upregulated by taxifol…

Supplementary Table S1 from Neural Cell Adhesion Protein CNTN1 Promotes the Metastatic Progression of Prostate Cancer Open