Feng‐Ying Huang
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View article: EEG insights into predictive coding of temporal regularity in shape sequences
EEG insights into predictive coding of temporal regularity in shape sequences Open
The human brain extracts statistical regularities from sensory input as a foundational mechanism for anticipating future events. This process, known as statistical learning (SL), underpins predictive coding across diverse sensory modalitie…
View article: Modular generation of multispecific antibodies using protein trans-splicing
Modular generation of multispecific antibodies using protein trans-splicing Open
Multispecific antibodies are exhibiting rapid growth in drug development due to their ability to engage multiple therapeutic targets and deliver unique functional properties inaccessible to conventional monoclonal antibodies. The developme…
View article: 3'-epi-12β-hydroxyfroside induces autophagic degradation of ABCG2 to overcome drug resistance in lung cancer cells
3'-epi-12β-hydroxyfroside induces autophagic degradation of ABCG2 to overcome drug resistance in lung cancer cells Open
These findings highlight the potential of HyFS in overcoming drug resistance through autophagy-dependent degradation of ABCG2, suggesting its promise as a therapeutic approach against ABCG2-mediated drug resistance in lung cancer cells.
View article: Cascade Reactions of Enone‐Tethered Ketones and Aldehydes with Indoles: Substrate‐Controlled Divergent Synthesis of Indenes and Indanes
Cascade Reactions of Enone‐Tethered Ketones and Aldehydes with Indoles: Substrate‐Controlled Divergent Synthesis of Indenes and Indanes Open
A cascade strategy involving the reactions of enone‐tethered ketones with indoles for the synthesis of indenes is outlined in the presence of iodine as a catalyst. Halogen bonding between molecular iodine and enones activates substrates to…
View article: Impacts of night shift on medical professionals: a pilot study of brain connectivity and gut microbiota
Impacts of night shift on medical professionals: a pilot study of brain connectivity and gut microbiota Open
Night shift is a prevalent workstyle in medical hospitals, demanding continuous health monitoring and rapid decision making of medical professionals. Night shifts may cause serious health problems to medical staff, including cognitive impa…
View article: Reinforcing cancer immunotherapy with engineered porous hollow mycobacterium tuberculosis loaded with tumor neoantigens
Reinforcing cancer immunotherapy with engineered porous hollow mycobacterium tuberculosis loaded with tumor neoantigens Open
Background Enhancing antigen cross-presentation is essential for the development of a tumor neoantigen vaccine. One approach is to stimulate antigen-presenting cells (APCs) to uptake neoantigens. Mycobacterium tuberculosis (MTb) contains p…
View article: Classification of internet addiction using machine learning on electroencephalography synchronization and functional connectivity
Classification of internet addiction using machine learning on electroencephalography synchronization and functional connectivity Open
Background Internet addiction (IA) refers to excessive internet use that causes cognitive impairment or distress. Understanding the neurophysiological mechanisms underpinning IA is crucial for enabling an accurate diagnosis and informing t…
View article: Loneliness modulates the neural dynamics of language processing in healthy older adults: evidence from event-related potentials
Loneliness modulates the neural dynamics of language processing in healthy older adults: evidence from event-related potentials Open
Loneliness, a distressing emotional response to perceived deficiencies in social interactions, has seen a marked increase in prevalence since the COVID-19 pandemic. While previous research has linked loneliness in older adults to affective…
View article: Impact of Facial Features on Social Perception and Decision-Making: An Examination of Developmental, Cultural, and Cognitive Factors in Face Reading
Impact of Facial Features on Social Perception and Decision-Making: An Examination of Developmental, Cultural, and Cognitive Factors in Face Reading Open
The implications of face reading, or the impressions and perceptions individuals form on other individuals solely based on their facial features, is a significant factor to consider when evaluating daily social interactions and important d…
View article: Peak width of skeletonized mean diffusivity might be a better neuroimage marker for cognitive functions in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)
Peak width of skeletonized mean diffusivity might be a better neuroimage marker for cognitive functions in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Open
Background Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a monogenic subcortical ischemic vascular dementia (SIVD) caused NOTCH3 gene mutations. Many different neuroimaging methods …
View article: CoFE-RAG: A Comprehensive Full-chain Evaluation Framework for Retrieval-Augmented Generation with Enhanced Data Diversity
CoFE-RAG: A Comprehensive Full-chain Evaluation Framework for Retrieval-Augmented Generation with Enhanced Data Diversity Open
Retrieval-Augmented Generation (RAG) aims to enhance large language models (LLMs) to generate more accurate and reliable answers with the help of the retrieved context from external knowledge sources, thereby reducing the incidence of hall…
View article: Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults
Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults Open
Understanding how sleep affects the glymphatic system and human brain networks is crucial for elucidating the neurophysiological mechanism underpinning aging-related memory declines. We analyzed a multimodal dataset collected through magne…
View article: IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release
IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release Open
T cell engagers (TCEs) are becoming an integral class of biological therapeutic owing to their highly potent ability to eradicate cancer cells. Nevertheless, the widespread utility of classical CD3-targeted TCEs has been limited by narrow …
View article: Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer
Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer Open
Phosphatases can dephosphorylate phosphorylated kinases, leading to their inactivation, and ferroptosis is a type of cell death. Therefore, our aim is to identify phosphatases associated with ferroptosis by analyzing the differentially exp…
View article: Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C <sub>H</sub> 1-C <sub>λ</sub> interface
Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C <sub>H</sub> 1-C <sub>λ</sub> interface Open
Bispecific antibodies represent an increasingly large fraction of biologics in therapeutic development due to their expanded scope in functional capabilities. Asymmetric monovalent bispecific IgGs (bsIgGs) have the additional advantage of …
View article: Gankyrin inhibits ferroptosis through the P53/SLC7A11/GPX4 axis in Triple-negative breast cancer cells
Gankyrin inhibits ferroptosis through the P53/SLC7A11/GPX4 axis in Triple-negative breast cancer cells Open
Gankyrin is found in high levels in triple-negative breast cancer (TNBC) and has been established to form a complex with the E3 ubiquitin ligase MDM2 and p53, resulting in the degradation of p53 in hepatocarcinoma cells. Therefore, this st…
View article: Table of Contents
Table of Contents Open
A prioritization approach based on a cross-
View article: Interoceptive awareness: MBSR training alters information processing of salience network
Interoceptive awareness: MBSR training alters information processing of salience network Open
Mindfulness refers to a mental state of awareness of internal experience without judgment. Studies have suggested that each mindfulness practice may involve a unique mental state, but the underlying neurophysiological mechanisms remain unk…
View article: Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques
Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques Open
Physical activity in the form of aerobic exercise has many beneficial effects on brain function. Here, we aim to revisit the effects of exercise on brain morphology and neurovascular organization using a rat running model. Electrocorticogr…
View article: Enhanced electroencephalography effective connectivity in frontal low‐gamma band correlates of emotional regulation after mindfulness training
Enhanced electroencephalography effective connectivity in frontal low‐gamma band correlates of emotional regulation after mindfulness training Open
Practicing mindfulness, focusing attention on the internal and external experiences occurring in the present moment with open and nonjudgement stance, can lead to the development of emotional regulation skills. Yet, the effective connectiv…
View article: Review of EEG-based neurofeedback as a therapeutic intervention to treat depression
Review of EEG-based neurofeedback as a therapeutic intervention to treat depression Open
Depression, or major depressive disorder, is a common mental disorder that affects individuals' behavior, mood, and physical health, and its prevalence has increased during the lockdowns implemented to curb the COVID-19 pandemic. There is …
View article: 3′-epi-12β-hydroxyfroside-mediated autophagy degradation of RIPK1/RIPK3 necrosomes leads to anergy of immunogenic cell death in triple-negative breast cancer cells
3′-epi-12β-hydroxyfroside-mediated autophagy degradation of RIPK1/RIPK3 necrosomes leads to anergy of immunogenic cell death in triple-negative breast cancer cells Open
Increasing studies have suggested that some cardiac glycosides, such as conventional digoxin (DIG) and digitoxin, can induce immunogenic cell death (ICD) in various tumors. We previously found that 3'-epi-12β-hydroxyfroside (HyFS), a novel…
View article: Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample Entropy analysis from resting-state fMRI
Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample Entropy analysis from resting-state fMRI Open
Resting-state fMRI has been widely used in investigating the pathophysiology of late-life depression (LLD). Unlike the conventional linear approach, cross-sample entropy (CSE) analysis shows the nonlinear property in fMRI signals between b…
View article: The effects of aging and perceived loneliness on lexical ambiguity resolution
The effects of aging and perceived loneliness on lexical ambiguity resolution Open
Language is central to the interactional nature of the social life within which it is situated. To react or respond in a particular situation, we must be able to recognize the social situation. Growing evidence has demonstrated the negativ…
View article: Classification of Major Depressive Disorder using Machine Learning on brain structure and functional connectivity
Classification of Major Depressive Disorder using Machine Learning on brain structure and functional connectivity Open
Background: Timely identification of the risk of having Major Depressive Disorder (MDD) using the advanced machine learning (ML) approach has been popularized to generate neural indicators of MDD. However, past ML studies have usually empl…
View article: Neurofeedback for the Education of Children with ADHD and Specific Learning Disorders: A Review
Neurofeedback for the Education of Children with ADHD and Specific Learning Disorders: A Review Open
Neurofeedback (NF) is a type of biofeedback in which an individual’s brain activity is measured and presented to them to support self-regulation of ongoing brain oscillations and achieve specific behavioral and neurophysiological outcomes.…
View article: The Neurobiological Basis of Love: A Meta-Analysis of Human Functional Neuroimaging Studies of Maternal and Passionate Love
The Neurobiological Basis of Love: A Meta-Analysis of Human Functional Neuroimaging Studies of Maternal and Passionate Love Open
Maternal and passionate love are both crucial for reproduction and involve attachment behaviors with high rewards. Neurobiological studies of attachment in animal and human neuroimaging studies have suggested that the coordination of oxyto…