Fenil Shah
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View article: Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression
Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. However, the potential contribution of the primary fibrinolytic protease plasminoge…
View article: Correction: Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours
Correction: Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours Open
View article: Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target
Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target Open
View article: Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours Open
Background MPNST is a rare soft-tissue sarcoma that can arise from patients with NF1. Existing chemotherapeutic and targeted agents have been unsuccessful in MPNST treatment, and recent findings implicate STAT3 and HIF1-α in driving MPNST.…
View article: Ref-1 Redox Activity Alters Cancer Cell Metabolism in Pancreatic Cancer: Exploiting This Novel Finding as a Potential Target  
Ref-1 Redox Activity Alters Cancer Cell Metabolism in Pancreatic Cancer: Exploiting This Novel Finding as a Potential Target Open
Background: Pancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to making advances in…
View article: Combined inhibition of Ref‐1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co‐culture models
Combined inhibition of Ref‐1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co‐culture models Open
With a plethora of molecularly targeted agents under investigation in cancer, a clear need exists to understand which pathways can be targeted simultaneously with multiple agents to elicit a maximal killing effect on the tumour. Combinatio…
View article: Original Research Article_Functional somatic symptoms in patients with major depressive disorder in a tertiary care hospital
Original Research Article_Functional somatic symptoms in patients with major depressive disorder in a tertiary care hospital Open
Background: Functional somatic symtpoms are common in patients with major depressive disorder.The aim of the research was to study the prevalence and typology of Functional Somatic Symptoms (FSS) in patients with depression.Methodology: A …
View article: Co-relation between cervicothoracic angle and neck pain in adults
Co-relation between cervicothoracic angle and neck pain in adults Open
View article: LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data
LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data Open
A key challenge in modeling single-cell RNA-seq data is to capture the diversity of gene expression states regulated by different transcriptional regulatory inputs across individual cells, which is further complicated by largely observed z…
View article: Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in a small fraction of cases, PDAC is inherently resistant to current treatments, a…
View article: Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization
Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization Open
Ocular neovascular diseases like wet age-related macular degeneration are a major cause of blindness. Novel therapies are greatly needed for these diseases. One appealing antiangiogenic target is reduction-oxidation factor 1–apurinic/apyri…
View article: LTMG: A novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data
LTMG: A novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data Open
A key challenge in modeling single-cell RNA-seq (scRNA-seq) data is to capture the diverse gene expression states regulated by different transcriptional regulatory inputs across single cells, which is further complicated by a large number …
View article: Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival Open
View article: Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization
Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization Open
View article: Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization
Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization Open
Ocular neovascular diseases like wet age-related macular degeneration are a major cause of blindness. Novel therapies are greatly needed for these diseases. One appealing antiangiogenic target is reduction-oxidation factor 1-apurinic/apyri…
View article: <scp>APE</scp>1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell<scp>RNA</scp>sequencing
<span>APE</span>1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell<span>RNA</span>sequencing Open
Apurinic/apyrimidinic endonuclease 1/redox factor‐1 ( APE 1/Ref‐1 or APE 1) is a multifunctional protein that regulates numerous transcription factors associated with cancer‐related pathways. Because APE 1 is essential for cell viability, …
View article: Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic Open
View article: The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2
The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2 Open
View article: Targeting Ref-1/APE1 Pathway Inhibition in Pancreatic Cancer Using APX3330 for Clinical Trials
Targeting Ref-1/APE1 Pathway Inhibition in Pancreatic Cancer Using APX3330 for Clinical Trials Open
View article: The thioredoxin system in breast cancer cell invasion and migration
The thioredoxin system in breast cancer cell invasion and migration Open
View article: The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription
The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription Open