Fenyong Sun
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View article: Immune-related cardiotoxicities predict immune checkpoint inhibitors treatment for advanced non-small cell lung cancer: a retrospective multi-center study
Immune-related cardiotoxicities predict immune checkpoint inhibitors treatment for advanced non-small cell lung cancer: a retrospective multi-center study Open
Mild irAEs or immune-related cardiotoxicities (grade 1-2) did not extend median OS in NSCLC patients. The prognostic model incorporating PLR, CEA, and CYFRA21-1 could contribute to predicting the treatment efficacy and prognosis of ICI tre…
View article: Global, regional, and national disease burden of multidrug-resistant tuberculosis without extensive drug resistance, 1990–2021: Findings from the Global Burden of Disease Study 2021
Global, regional, and national disease burden of multidrug-resistant tuberculosis without extensive drug resistance, 1990–2021: Findings from the Global Burden of Disease Study 2021 Open
This study revealed that the global disease burden of MDR-TB increased from 1990 to 2021 and is predicted to grow till 2050. Disparities among different social-demographic regions were remarkable and extended over time. Epidemiological cha…
View article: Engineered Microneedle System Enables the Smart Regulation of Nanodynamic Sterilization and Tissue Regeneration for Wound Management
Engineered Microneedle System Enables the Smart Regulation of Nanodynamic Sterilization and Tissue Regeneration for Wound Management Open
The healing of bacterial biofilm‐infected wounds is a complex process, and the construction of emerging therapeutic modalities that regulate the microenvironment to magnify therapeutic effects and reduce biotoxicity is still highly challen…
View article: METTL14 Mediates <i>Glut3</i> m6A methylation to improve osteogenesis under oxidative stress condition
METTL14 Mediates <i>Glut3</i> m6A methylation to improve osteogenesis under oxidative stress condition Open
METTL14 could serve as a potential therapeutic approach for enhancing osteoporosis treatment.
View article: Northern Shanghai Study II: systematic assessment and management of early organ damage and its role in preventing and reducing cardiovascular risk—protocol of a prospective study
Northern Shanghai Study II: systematic assessment and management of early organ damage and its role in preventing and reducing cardiovascular risk—protocol of a prospective study Open
Introduction Cardiovascular diseases are the leading cause of death and disease burden in China. However, there is a lack of prospective cohort studies suitable for evaluating early organ damage and its role in preventing and reducing card…
View article: Correction: Li et al. m6A mRNA Methylation Regulates LKB1 to Promote Autophagy of Hepatoblastoma Cells through Upregulated Phosphorylation of AMPK. Genes 2021, 12, 1747
Correction: Li et al. m6A mRNA Methylation Regulates LKB1 to Promote Autophagy of Hepatoblastoma Cells through Upregulated Phosphorylation of AMPK. Genes 2021, 12, 1747 Open
In the original publication [...]
View article: Anti-ferroptotic PRKAA2 serves as a potential diagnostic and prognostic marker for hepatoblastoma
Anti-ferroptotic PRKAA2 serves as a potential diagnostic and prognostic marker for hepatoblastoma Open
PRKAA2 functions as a tumor-promoting factor in HB by promoting cell proliferation and prohibiting ferroptosis. Ferroptosis-related genes PRKAA2 is a potential diagnostic and prognostic marker for HB as well as a novel therapeutic target i…
View article: Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of <i>RAD51</i> functions
Identification of key enzalutamide-resistance-related genes in castration-resistant prostate cancer and verification of <i>RAD51</i> functions Open
Patients with castration-resistant prostate cancer (CRPC) often develop drug resistance after treatment with enzalutamide. The goal of our study was to identify the key genes related to enzalutamide resistance in CRPC and to provide new ge…
View article: YAP ISGylation increases its stability and promotes its positive regulation on PPP by stimulating 6PGL transcription
YAP ISGylation increases its stability and promotes its positive regulation on PPP by stimulating 6PGL transcription Open
Yes-associated protein (YAP) activation is crucial for tumor formation and development, and its stability is regulated by ubiquitination. ISGylation is a type of ubiquitination like post-translational modification, whereas whether YAP is I…
View article: Tumour cells are sensitised to ferroptosis via RB1CC1‐mediated transcriptional reprogramming
Tumour cells are sensitised to ferroptosis via RB1CC1‐mediated transcriptional reprogramming Open
Background Ferroptosis, a form of regulated cell death, is an important topic in the field of cancer research. However, the signalling pathways and factors that sensitise tumour cells to ferroptosis remain elusive. Methods We determined th…
View article: m6A mRNA Methylation Regulates LKB1 to Promote Autophagy of Hepatoblastoma Cells through Upregulated Phosphorylation of AMPK
m6A mRNA Methylation Regulates LKB1 to Promote Autophagy of Hepatoblastoma Cells through Upregulated Phosphorylation of AMPK Open
The N6-methyladenosine (m6A) RNA modification can regulate autophagy to modulate the growth and development of tumors, but the mechanism of m6A modification for the regulation of autophagy in hepatocellular carcinoma cells (HCC) remains un…
View article: N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis via Differentially Regulating Ubiquitination of Targets
N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis via Differentially Regulating Ubiquitination of Targets Open
Background A tremendous amount of studies have suggested that post-translational modifications (PTMs) play pivotal roles during tumorigenesis. Compared to other PTMs, lipid modification is less studied. Recently, N-myristoylation, one type…
View article: O-GlcNAcylated c-Jun antagonizes ferroptosis via inhibiting GSH synthesis in liver cancer
O-GlcNAcylated c-Jun antagonizes ferroptosis via inhibiting GSH synthesis in liver cancer Open
Ferroptosis is a metabolism-related cell death. Stimulating ferroptosis in liver cancer cells is a strategy to treat liver cancer. However, how to eradicate liver cancer cells through ferroptosis and the obstacles to inducing ferroptosis i…
View article: <i>MIR145-3p</i>promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting<i>HDAC4</i>
<i>MIR145-3p</i>promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting<i>HDAC4</i> Open
Multiple myeloma (MM) is an incurable plasma cell malignancy with poor survival. Autophagy, a stress-responsive catabolic process mediated by lysosomal activity, plays a crucial role in the pathophysiology of MM. Growing evidence has indic…
View article: ILF2 Directly Binds and Stabilizes CREB to Stimulate Malignant Phenotypes of Liver Cancer Cells
ILF2 Directly Binds and Stabilizes CREB to Stimulate Malignant Phenotypes of Liver Cancer Cells Open
Cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) is overexpressed and has an oncogenic role in hepatocellular carcinoma (HCC). Interleukin enhancer binding factor 2 (ILF2) has become research hotspot in liver c…
View article: circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma
circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma Open
Some types of circular RNA (circRNA) are aberrantly expressed in human diseases including hepatocellular carcinoma (HCC). However, its regulation mechanism and diagnostic roles are largely unknown. Here, we identified that circRNA_104075 (…
View article: (−)-Guaiol regulates autophagic cell death depending on mTOR signaling in NSCLC
(−)-Guaiol regulates autophagic cell death depending on mTOR signaling in NSCLC Open
(-)-Guaiol, a sesquiterpene alcohol with the guaiane skeleton, has been found in many Chinese medicinal plants and been reported to comprise various guaiane natural products that are well known for their antibacterial activities. Previousl…
View article: Upregulation of AKAP12 with HDAC3 depletion suppresses the progression and migration of colorectal cancer
Upregulation of AKAP12 with HDAC3 depletion suppresses the progression and migration of colorectal cancer Open
A-kinase anchor protein 12 (AKAP12; also known as Gravin) functions as a tumor suppressor in several human primary cancers. However, the potential correlation between histone deacetylase 3 (HDAC3) and AKAP12 and the underlying mechanisms r…
View article: TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy
TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy Open
Although YAP-dependent transcription is closely associated with liver tumorigenesis, the mechanism by which YAP maintains its function is poorly understood. Here, we show that TFCP2 is required for YAP-dependent transcription and liver mal…
View article: Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells
Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells Open
Sirtuin 6, a member of sirtuin family, is generally regarded as a tumor suppressor as it participates in suppressing hypoxia-inducible factor 1α and MYC transcription activity by deacetylating H3K9 (histone H3 lysine 9) and H3K56 (histone …
View article: (−)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer
(−)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer Open
(-)-Guaiol, generally known as an antibacterial compound, has been found in many medicinal plants. Its roles in tumor suppression are still under investigation. In the study, we mainly focused on exploring its applications in dealing with …