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View article: Expression Alterations and Correlative Analysis of TPH1/hsa-miR-194-5p/NEAT1 and MAOA/hsa-miR-1276/NEAT1 Axes in Pediatric Inflammatory Bowel Disease
Expression Alterations and Correlative Analysis of TPH1/hsa-miR-194-5p/NEAT1 and MAOA/hsa-miR-1276/NEAT1 Axes in Pediatric Inflammatory Bowel Disease Open
Pediatric inflammatory bowel disease (pIBD), comprising ulcerative colitis (UC) and Crohn’s disease (CD), involves complex mechanisms that include non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), alo…
View article: Axillary Pathological Complete Response After Neoadjuvant Therapy in cN1–2 Breast Cancer: An Internally Validated PET/CT-Integrated Nomogram
Axillary Pathological Complete Response After Neoadjuvant Therapy in cN1–2 Breast Cancer: An Internally Validated PET/CT-Integrated Nomogram Open
We aimed to develop and internally validate a nomogram to estimate axillary pathological complete response (pCR, ypN0) after neoadjuvant systemic therapy (NAST) in clinically node-positive (cN1–2) breast cancer. In a single-center retrospe…
View article: Measuring Surgical Waiting Times in Breast Cancer: Admission to Surgery Versus Biopsy Result to Surgery
Measuring Surgical Waiting Times in Breast Cancer: Admission to Surgery Versus Biopsy Result to Surgery Open
Background: Preoperative timelines may lengthen due to tailored evaluation and system constraints. We examined whether two complementary measures of time-to-surgery (TTS)—admission-to-surgery (A-TTS) and biopsy-result-to-surgery (B-TTS)—be…
View article: Triple-Negative Breast Cancer and Ferroptosis: Expression Profiling of Key Regulatory Genes
Triple-Negative Breast Cancer and Ferroptosis: Expression Profiling of Key Regulatory Genes Open
Introduction Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Ferroptosi…
View article: SPECT/CT in the Diagnosis of Ectopic Gastric Mucosa-Meckel's Diverticulum
SPECT/CT in the Diagnosis of Ectopic Gastric Mucosa-Meckel's Diverticulum Open
Aim The imaging of Meckel's diverticulum (MD) is based of accumulation of Tc-99m pertechnetate in the ectopic gastric mucosa (EGM) content. Although the diagnostic accuracy of this imaging modality is high, there are some overlap patients …
View article: Clinicopathological characteristics and BRCA1/BRCA2 pathogenic variants of patients with breast cancer
Clinicopathological characteristics and BRCA1/BRCA2 pathogenic variants of patients with breast cancer Open
Although BRCA genes are well-known breast cancer genes, the clinicopathological features of breast cancer patients carrying BRCA1/2 pathogenic variants have not been adequately defined. The goals of this study were to determine the distrib…
View article: Expression levels of genes involved in lipogenesis and cholesterol synthesis in adenomyosis
Expression levels of genes involved in lipogenesis and cholesterol synthesis in adenomyosis Open
Objectives Adenomyosis is a benign uterine disease that occurs with the invasion of the endometrial gland and stoma into the myometrium. The etiology and molecular pathology of adenomyosis are not yet fully understood. Tissue samples of pa…
View article: Role of acetyl-CoA acetyltransferase 1 expression in the molecular mechanism of adenomyosis
Role of acetyl-CoA acetyltransferase 1 expression in the molecular mechanism of adenomyosis Open
The results suggest that ACAT1 may be associated with the molecular pathogenesis of adenomyosis.
View article: Efficacy of ABCA1 Transporter Proteins in Endometrial Cancer
Efficacy of ABCA1 Transporter Proteins in Endometrial Cancer Open
According to the findings of our study, a key component in the growth of EC tumors is the increase in cholesterol production caused by a reduction in ABCA1.
View article: Encapsulated Papillary Carcinoma of the Breast Clinicopathological Features and Management: Could Sentinel Lymph Node Biopsy Be Exempted?
Encapsulated Papillary Carcinoma of the Breast Clinicopathological Features and Management: Could Sentinel Lymph Node Biopsy Be Exempted? Open
Background Any papillary lesion in the breast presents a diagnostic and therapeutic challenge. Encapsulated papillary carcinoma (ECP) is one of the rare types of breast cancer. Evidence-based guidelines are sparse. For this reason, there i…
View article: Novel immunohistochemical marker in the differential diagnosis of sex cord-stromal tumors: SF-1
Novel immunohistochemical marker in the differential diagnosis of sex cord-stromal tumors: SF-1 Open
View article: Pediatrik hastalarda kolonoskopi bulgularının değerlendirilmesi; Tek merkez deneyimi
Pediatrik hastalarda kolonoskopi bulgularının değerlendirilmesi; Tek merkez deneyimi Open
Amaç: Çalışmada, kolonoskopi yapılan çocuk hastalarda başvuru semptomları, işlem endikasyonları, sonuçlar ve komplikasyonların değerlendirilmesi amaçlandı. Yöntem: Çalışmaya Ocak 2008 ile Aralık 2020 tarihleri arasında kolonoskopi yapılan …
View article: Kronik viral hepatitli olgularda kombine non-alkolik yağlı karaciğer hastalığının sıklığı ve önemi
Kronik viral hepatitli olgularda kombine non-alkolik yağlı karaciğer hastalığının sıklığı ve önemi Open
eden hepatosteatozun belirlenerek bunların skorlama sistemlerindeki parametreler ile ilişkisinin ortaya konması ve böylelikle hastalığın seyri ile ilgili öngörüde bulunmaktır. Yöntem: İki farklı üniversite hastanesinde kronik viral hepatit…
View article: Kolon Poliplerinin Ayırıcı Tanısında Yeni Bir Yaklaşım; Stereoloji
Kolon Poliplerinin Ayırıcı Tanısında Yeni Bir Yaklaşım; Stereoloji Open
Amaç: Bu çalışmanın amacı; neoplastik potansiyeli de olabilen kolon poliplerinin histopatolojik özelliklerine göre sınıflandığında tanı güçlüğü oluşturabilen olgular için tanıda kullanılabilecek stereoloji yönteminin değerini araştırmaktır…
View article: Çölyak hastalığında serolojik, endoskopik ve histopatolojik bulguların karşılaştırılması; tanı için öneriler
Çölyak hastalığında serolojik, endoskopik ve histopatolojik bulguların karşılaştırılması; tanı için öneriler Open
Giriş ve Amaç: Dünya genelinde %1 prevalans ile görülen bir antite olan çölyak hastalığı, farklı yaşlarda ve farklı klinikler ile prezente olabilen bir hastalıktır. Tanı için klinik, serolojik ve histolojik özelliklerin korelasyonu önem ar…
View article: Vandetanib in a Child Affected by Neurofibromatosis Type 1 and Medullary Thyroid Carcinoma with Both <i>NF1</i> and Homozygous <i>RET</i> Proto-oncogen Germ-line Mutations
Vandetanib in a Child Affected by Neurofibromatosis Type 1 and Medullary Thyroid Carcinoma with Both <i>NF1</i> and Homozygous <i>RET</i> Proto-oncogen Germ-line Mutations Open
Cases of neurofibromatosis type 1 (NF1)-associated medullary thyroid carcinoma (MTC) or C-cell hyperplasia are rarely associated with other endocrine tumors or cases with a multiple endocrine neoplasia type 2. In these patients, mut…
View article: Childhood Pilomatrixoma: Case Series from a Single Center
Childhood Pilomatrixoma: Case Series from a Single Center Open
Objective: The aim of this study is to describe our institutional experience with pilomatrixoma in children, specifically examining its clinical presentation, associated conditions, radiological and pathological findings and attract attent…
View article: The role of COL6A1and PD-1 expressions in renal cell carcinoma
The role of COL6A1and PD-1 expressions in renal cell carcinoma Open
In high-grade RCCs, we found the relationship between immunohistochemical staining scores of COL6A1 and PD-1 proteins and clinical, demographic, and histopathological parameters. Our results proved that COL6A1 and PD-1 are really promising…
View article: The value of maspin and PD-L1 expression and peritumoral lymphocytic infiltration in breast tumors
The value of maspin and PD-L1 expression and peritumoral lymphocytic infiltration in breast tumors Open
In our study, PD-L1 expression was detected in breast cancer, and was associated with triple negativity and high grade. Our results show that the Maspin expression and lymphocyte density are associated with the prognosis (Tab. 5, Fig. 4, R…
View article: Value of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio and red blood cell distribution width in distinguishing between reactive lymphadenopathy and lymphoma in children
Value of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio and red blood cell distribution width in distinguishing between reactive lymphadenopathy and lymphoma in children Open
Children with histologically proven lymphoma have higher NLR, MLR, PLR, and RDW values than children with reactive LAP. NLR, MLR, PLR, and RDW tests, which can be performed even in primary health care centers, may be useful markers to dete…
View article: Çocukluk çağında çölyak hastalığı ve Helicobacter pylori gastritinin görülme sıklığı ile aralarındaki ilişki
Çocukluk çağında çölyak hastalığı ve Helicobacter pylori gastritinin görülme sıklığı ile aralarındaki ilişki Open
Giriş ve Amaç: Mikrobiyal maruziyetin çölyak hastalık riskini etkileyebileceği, kronik gastrik enfeksiyonların sistemik immün yanıtları etkileyerek ince bağırsakta otoimmüniteyi tetikleyebileceği ileri sürülmektedir. Bu çalışmanın amacı me…
View article: The Correlation between<i>IL-1β-C31T</i>Gene Polymorphism and Susceptibility to Breast Cancer
The Correlation between<i>IL-1β-C31T</i>Gene Polymorphism and Susceptibility to Breast Cancer Open
The IL-1β-C31T polymorphism affects breast cancer susceptibility, especially in women with late age at first birth, high BMI, postmenopausal status, negative smoking history, and invasive ductal carcinoma. Our study adds to the evid…
View article: Pediatric sweet syndrome: A rare cause of fever of unknown origin
Pediatric sweet syndrome: A rare cause of fever of unknown origin Open
Sweet syndrome or acute febrile neutrophilic dermatosis, is characte rized by fever, elevated neutrophil count, painful erythematous cutaneous lesions that have an infiltrate of mature neutrophils typically located in the upper dermis.In g…
View article: IMPORTANCE OF INTRAOPERATIVE CONSULTATION IN BREAST SURGERY AND SENTINEL LYMPH NODE BIOPSY
IMPORTANCE OF INTRAOPERATIVE CONSULTATION IN BREAST SURGERY AND SENTINEL LYMPH NODE BIOPSY Open
Objective: Evaluation of the surgical margins in ROLL mastectomymaterials, and assessment of the safety and the usability of theintra-operative consultation and frozen section for the evaluation of the sentinellymph node biopsy (SLNB). Met…
View article: The expressions of p16 and p21 to predict the clinicopathological behavior and prognosis of gastric cancer
The expressions of p16 and p21 to predict the clinicopathological behavior and prognosis of gastric cancer Open
In this study, the associations of expression of two cell cycle proteins, p16 and p21, with conventional prognostic parameters and survival were investigated in gastric carcinomas. The expression of p16 and p21 were investigated by immunoh…
View article: EKRİN HİDROKİSTOM: OLGU SUNUMU EŞLİĞİNDE LİTERATÜR DERLEMESİ
EKRİN HİDROKİSTOM: OLGU SUNUMU EŞLİĞİNDE LİTERATÜR DERLEMESİ Open
Ekrin hidrokistomlar, çoğunlukla kadınlarda, sıklıkla yüz ve gözkapağında görülen, ekrin duktuslardan kökenalan, benign lezyonlardır. Ekrin hidrokistomların görülme sıklığı tam olarak bilinmemektedir ve ayırıcı tanısındabenign ve malign bi…