Ferenc Reinhardt
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View article: Inflammation awakens dormant cancer cells by modulating the epithelial–mesenchymal phenotypic state
Inflammation awakens dormant cancer cells by modulating the epithelial–mesenchymal phenotypic state Open
The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses of patients whose primary tumors have been successfully cured months and even years earlier. In the present study, we demonstrate that d…
View article: CD47 predominates over CD24 as a macrophage immune checkpoint in cancer
CD47 predominates over CD24 as a macrophage immune checkpoint in cancer Open
Macrophages hold tremendous promise as effectors of cancer immunotherapy, but the best strategies to provoke these cells to attack tumors remain unknown. Here, we evaluated the therapeutic potential of targeting two distinct macrophage imm…
View article: Ether lipids influence cancer cell fate by modulating iron uptake
Ether lipids influence cancer cell fate by modulating iron uptake Open
Cancer cell fate has been widely ascribed to mutational changes within proteincoding genes associated with tumor suppressors and oncogenes. In contrast, the mechanisms through which the biophysical properties of membrane lipids influence c…
View article: Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer Open
Clinical and molecular evidence indicates that high-grade serous ovarian cancer (HGSOC) primarily originates from the fallopian tube, not the ovarian surface. However, the reasons for this preference remain unclear. Our study highlights si…
View article: Inaugurating High‐Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection (Adv. Sci. 27/2023)
Inaugurating High‐Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection (Adv. Sci. 27/2023) Open
Early Cancer Message from the Source Most high‐grade serous ovarian cancers originate from the precursor lesions in the fallopian tube. This biological insight offers a novel opportunity to detect early ovarian cancer by assessing circulat…
View article: Inaugurating High‐Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection
Inaugurating High‐Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection Open
Detecting early cancer through liquid biopsy is challenging due to the lack of specific biomarkers for early lesions and potentially low levels of these markers. The current study systematically develops an extracellular‐vesicle (EV)‐based…
View article: Supplementary Data from Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas
Supplementary Data from Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas Open
This file contains Supplementary Figures 1-8 and Supplementary Tables #1-2
View article: Supplementary Methods, Figure Legends 1-12 from Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E<sub>2</sub> Signaling
Supplementary Methods, Figure Legends 1-12 from Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E<sub>2</sub> Signaling Open
PDF file - 217K
View article: Supplementary Methods, Figure Legends 1-12 from Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E<sub>2</sub> Signaling
Supplementary Methods, Figure Legends 1-12 from Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E<sub>2</sub> Signaling Open
PDF file - 217K
View article: Supplementary Methods from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions
Supplementary Methods from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions Open
PDF file - 216K
View article: Supplementary Tables from Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress
Supplementary Tables from Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress Open
PDF file 59K, Table S1: GSEA of microarray data from Cmp302-treated cells; Table S2: ECM gene expression in luminal and basal-B breast cancer lines
View article: Supplementary Movie 2 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions
Supplementary Movie 2 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions Open
MOV file - 3.4MB, Kinetics of the assembly and disassembly of FLPs in cells cultured under MoT conditions
View article: Supplementary Figures 1-17 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions
Supplementary Figures 1-17 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions Open
PDF file - 1.8MB
View article: Supplementary Figure Legends from Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells
Supplementary Figure Legends from Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells Open
Supplementary Figure Legends
View article: Supplementary Data from Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy
Supplementary Data from Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy Open
Supplementary data includes suppl methods, FigS1-7， Table S1-6, Methods Tables 1-5
View article: Data from Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells
Data from Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells Open
Immune cells promote the initial metastatic dissemination of carcinoma cells from primary tumors. In contrast to their well-studied functions in the initial stages of metastasis, the specific roles of immunocytes in facilitating progressio…
View article: Supplementary Movie 1 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions
Supplementary Movie 1 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions Open
MOV file - 3.4MB, Kinetics of the assembly and disassembly of filopodia in cells cultured under monolayer conditions
View article: Supplementary Figures 1-12 from Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E<sub>2</sub> Signaling
Supplementary Figures 1-12 from Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E<sub>2</sub> Signaling Open
PDF file - 1.4MB, Fig. S1. IL-1 secreting carcinoma cells are able to induce PGE2 from MSCs; Fig. S2. IL-1 and LoVoCM induce PGE2, IL-6, IL-8 and GRO-� expression in various mesenchymal cells; Fig. S3. MSCs are recruited to tumors in vivo;…
View article: Data from Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress
Data from Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress Open
Epithelial-to-mesenchymal transition (EMT) promotes both tumor progression and drug resistance, yet few vulnerabilities of this state have been identified. Using selective small molecules as cellular probes, we show that induction of EMT g…
View article: Supplementary Movie 1 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions
Supplementary Movie 1 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions Open
MOV file - 3.4MB, Kinetics of the assembly and disassembly of filopodia in cells cultured under monolayer conditions
View article: Supplementary Figures 1 - 5 from Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells
Supplementary Figures 1 - 5 from Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells Open
Supplementary Figure 1. Systemic neutrophilia in tumor bearing mice. Supplementary Figure 2. Increased metastasis does not result from increased intravasation or post-extravasation events. Supplementary Figure 3. NK-mediated clearance of B…
View article: Data from Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas
Data from Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas Open
The epithelial-to-mesenchymal transition, which conveys epithelial (E) carcinoma cells to quasi-mesenchymal (qM) states, enables them to metastasize and acquire resistance to certain treatments. Murine tumors composed of qM mammary carcino…
View article: Supplementary Data from Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas
Supplementary Data from Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas Open
This file contains Supplementary Figures 1-8 and Supplementary Tables #1-2
View article: Supplementary Materials from Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress
Supplementary Materials from Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress Open
PDF file 99K, Supplementary figure and table legends
View article: Data from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions
Data from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions Open
Disseminated cancer cells that have extravasated into the tissue parenchyma must interact productively with its extracellular matrix components to survive, proliferate, and form macroscopic metastases. The biochemical and cell biologic mec…
View article: Data from Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy
Data from Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy Open
Despite advances in immuno-oncology, the relationship between tumor genotypes and response to immunotherapy remains poorly understood, particularly in high-grade serous tubo-ovarian carcinomas (HGSC). We developed a series of mouse models …
View article: Data from Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells
Data from Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells Open
Immune cells promote the initial metastatic dissemination of carcinoma cells from primary tumors. In contrast to their well-studied functions in the initial stages of metastasis, the specific roles of immunocytes in facilitating progressio…
View article: Supplementary Figures 1-12 from Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E<sub>2</sub> Signaling
Supplementary Figures 1-12 from Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E<sub>2</sub> Signaling Open
PDF file - 1.4MB, Fig. S1. IL-1 secreting carcinoma cells are able to induce PGE2 from MSCs; Fig. S2. IL-1 and LoVoCM induce PGE2, IL-6, IL-8 and GRO-� expression in various mesenchymal cells; Fig. S3. MSCs are recruited to tumors in vivo;…
View article: Data from Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas
Data from Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas Open
The epithelial-to-mesenchymal transition, which conveys epithelial (E) carcinoma cells to quasi-mesenchymal (qM) states, enables them to metastasize and acquire resistance to certain treatments. Murine tumors composed of qM mammary carcino…
View article: Supplementary Movie 3 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions
Supplementary Movie 3 from The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions Open
MOV file - 3.4MB, Direct conversion of FLP-associated integrin clumps into the ones constituting adhesion plaques