Fereshteh Alsahebfosoul
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View article: Evaluation of circulating IL-35, IL-39, and oncostatin M as potential biomarkers in relapsing-remitting multiple sclerosis
Evaluation of circulating IL-35, IL-39, and oncostatin M as potential biomarkers in relapsing-remitting multiple sclerosis Open
Background: Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory demyelinating disease of the central nervous system (CNS). Hence, there is a need to identify more biomarkers that may assist in developing new therapeutic str…
View article: The Immunomodulatory Aspect of Quercetin Penta Acetate on Th17 Cells Proliferation and Gene Expression in Multiple Sclerosis.
The Immunomodulatory Aspect of Quercetin Penta Acetate on Th17 Cells Proliferation and Gene Expression in Multiple Sclerosis. Open
Taken together, our results showed some immunomodulatory aspects of Quercetin Penta Acetate on Th17 cells are more effective than Quercetin and it could be considered in the treatment of MS.
View article: Antidepressants and the Risk of Psoriasis Induction: A Case–Control Study
Antidepressants and the Risk of Psoriasis Induction: A Case–Control Study Open
Background: Psoriasis (PSO) is a common chronic autoimmune skin disease with a significant psycho-socio-economic burden. Some antidepressants (ADs) such as fluoxetine and bupropion can induce or exacerbate PSO. This study aimed to investig…
View article: Gastrointestinal Manifestations in Children with Kawasaki Disease in Isfahan, Iran
Gastrointestinal Manifestations in Children with Kawasaki Disease in Isfahan, Iran Open
Background: Kawasaki Disease (KD) is an acute systemic vasculitis that generally affects children. Patients with KD do not show all typical clinical symptoms of the disease. Objectives: Considering various studies in diagnosing the gastroi…
View article: Negative Regulation of Semaphorin-3A Expression in Peripheral Blood Mononuclear Cells Using MicroRNA-497-5p.
Negative Regulation of Semaphorin-3A Expression in Peripheral Blood Mononuclear Cells Using MicroRNA-497-5p. Open
Based on the obtained results, we suggest that miR-497-5p has a high suppressive effect on Sema3A expression and both Sema3A and miR-497-5p can be considered critical targets for further studies on future therapeutic attempts for the treat…
View article: Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients.
Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients. Open
The study findings suggest that in the clinically diagnosed celiac disease, IELs count/100 ECs below the upper normal limit as well as negative histopathological and serologic assays and the cell density counts of the CD8+ IELs T-cells/100…
View article: Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis
Interleukin 18 polymorphisms and its serum level in patients with multiple sclerosis Open
In this study, we showed the significant higher IL-18 serum level and significant different frequencies of two polymorphisms of IL-18 in MS patients. These results show the important roles of IL-18 in MS pathogenesis. However, more studies…
View article: Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis
Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis Open
Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS).Cluster of Differentiation 226 (CD226) is one of the risk factors for MS.Objectives: The present study aim…
View article: Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis
Gene Expression of CD226 and Its Serum Levels in Patients With Multiple Sclerosis Open
Background: Recent studies have found some genetic variants as a risk factor for autoimmune diseases such as Multiple Sclerosis (MS). Cluster of Differentiation 226 (CD226) is one of the risk factors for MS. Objectives: The present study a…
View article: OX40 Gene and Serum Protein Expression Profiles in Patients with Parkinson's Disease.
OX40 Gene and Serum Protein Expression Profiles in Patients with Parkinson's Disease. Open
We conclude that OX40 expression at either the transcript or protein level has no diagnostic utility in asymptomatic PD. This shows the need for clinical, cellular and interventional research to detect new robust biomarkers.
View article: Association of <i>AIRE</i> Polymorphism and the Susceptibility to Multiple Sclerosis in Iranian Population.
Association of <i>AIRE</i> Polymorphism and the Susceptibility to Multiple Sclerosis in Iranian Population. Open
This is the first study investigating the relationship between AIRE gene and the susceptibility to MS. These results indicated that the rs1800520 SNP is not a susceptibility gene variant for the development of MS in Iranian population.
View article: Serum levels of histamine and diamine oxidase in multiple sclerosis.
Serum levels of histamine and diamine oxidase in multiple sclerosis. Open
Our research team found significant low levels of histamine and diamine oxidase in RRMS patients; however the pathogenesis of this issue was unclear.
View article: The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study
The Serum Amyloid β Level in Multiple Sclerosis: A Case- Control Study Open
Background: Multiple sclerosis (MS) is one of the most common autoimmune diseases in adults that cause disability in patients.Different studies were conducted on more rapid diagnosis of the disease such as measuring serum or cerebrospinal …
View article: Interleukin-33 plasma levels in patients with relapsing-remitting multiple sclerosis
Interleukin-33 plasma levels in patients with relapsing-remitting multiple sclerosis Open
Cytokines are implicated in the immunopathogenesis of multiple sclerosis (MS). Interleukin (IL)-33, one of the recently discovered members of the IL-1 superfamily, is a dual functional cytokine involved in various autoimmune disorders. In …
View article: Association between CD127 Gene Polymorphism and Susceptibility to Multiple Sclerosis
Association between CD127 Gene Polymorphism and Susceptibility to Multiple Sclerosis Open
Background: Multiple Sclerosis (MS) is an autoimmune disease of Central Nervous System (CNS) which is supposed the interaction of genetic and environmental factors have a role in its pathogenesis.Previous studies have described association…
View article: Comparison of the expression levels of Fas and Apaf-1 genes in systemic sclerosis dermal fibroblasts
Comparison of the expression levels of Fas and Apaf-1 genes in systemic sclerosis dermal fibroblasts Open
Background: Systemic sclerosis (SSc) is an autoimmune rheumatic connective tissue disease. In normal wound healing process, fibroblasts are activated, proliferated and involved in tissue repair, and then removed by apoptosis. In systemic s…