Fergus G.P. Earley
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View article: Flometoquin, a novel insecticide, acts on mitochondrial complex III as a Q<sub>i</sub> inhibitor
Flometoquin, a novel insecticide, acts on mitochondrial complex III as a Q<sub>i</sub> inhibitor Open
Flometoquin (FLO) is a novel quinoline-type insecticide that elicits a quick knock-down effect against target pests; however, its mode of action (MoA) remains unknown. In this study, we investigated its MoA systematically, using varying bi…
View article: The mode of action of isocycloseram: A novel isoxazoline insecticide
The mode of action of isocycloseram: A novel isoxazoline insecticide Open
Isocycloseram is a novel isoxazoline insecticide and acaricide with activity against lepidopteran, hemipteran, coleopteran, thysanopteran and dipteran pest species. Isocycloseram selectively targets the invertebrate Rdl GABA receptor at a …
View article: Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins
Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins Open
Drosophila nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that represent a target for insecticides. Peptide neurotoxins are known to block nAChRs by binding to their target subunits, however, a better understandin…
View article: Author response: Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins
Author response: Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Drosophila nicotinic a…
View article: Insecticides, biologics and nematicides: Updates to IRAC’s mode of action classification - a tool for resistance management
Insecticides, biologics and nematicides: Updates to IRAC’s mode of action classification - a tool for resistance management Open
Insecticide resistance has been and continues to be a significant problem for invertebrate pest control. As such, effective insecticide resistance management (IRM) is critical to maintain the efficacy of current and future insecticides. A …
View article: Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor
Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor Open
The insecticidal effects of ω‐hexatoxin‐Hv1a, κ‐hexatoxin‐Hv1c and ω/κ‐hexatoxin‐Hv1h are currently attributed to action at calcium and potassium channels. By characterizing the binding of these toxins to neuronal membranes, we show that t…