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View article: How Parasocial Relationships Affected Psycho-emotional Aspects During Social Restrictions in the COVID-19 Pandemic
How Parasocial Relationships Affected Psycho-emotional Aspects During Social Restrictions in the COVID-19 Pandemic Open
This paper examines the effects of interpersonal and parasocial relationships as coping mechanisms, particularly during crises such as the COVID-19 pandemic. The study has three main objectives: (1) to analyze how parasocial relationships …
View article: Impactos da extrema pobreza no desenvolvimento cognitivo na primeira infância
Impactos da extrema pobreza no desenvolvimento cognitivo na primeira infância Open
Objetivo: Analisar os impactos da extrema pobreza no desenvolvimento cognitivo na primeira infância, considerando a importância desse período para a aquisição de habilidades cognitivas, sociais e emocionais. Métodos: Trata-se de uma revisã…
View article: Health and Environmental Impacts of Major Foods Consumed in Regional Food Systems of Brazil
Health and Environmental Impacts of Major Foods Consumed in Regional Food Systems of Brazil Open
This study examines the relationship between the 1141 most consumed foods in Brazil and their individual and combined health and environmental impacts. Foods are analyzed across different food system clusters, based on the health burden (D…
View article: Coronary Calcifications are a More Relevant Prognostic Factor for Lethality in Patients with COVID-19
Coronary Calcifications are a More Relevant Prognostic Factor for Lethality in Patients with COVID-19 Open
Background: The objective is to evaluate the prognostic factor of lethality of coronary calcifications by the scoring method of overall visual assessment in patients with COVID-19 who underwent chest computed tomography and also evaluate o…
View article: EP-153 - PIOMIOSITE TUBERCULOSA: UM RELATO DE CASO
EP-153 - PIOMIOSITE TUBERCULOSA: UM RELATO DE CASO Open
Introdução: A piomiosite tuberculosa é uma forma rara de tuberculose extrapulmonar, na maioria dos casos a infecção se estende por contiguidade. O quadro clínico é insidioso, inespecífico e variável, podendo o paciente não apresentar os es…
View article: In Vitro Astroglial Dysfunction Induced by Neurotoxins: Mimicking Astrocytic Metabolic Alterations of Alzheimer’s Disease
In Vitro Astroglial Dysfunction Induced by Neurotoxins: Mimicking Astrocytic Metabolic Alterations of Alzheimer’s Disease Open
Astrocytes play fundamental roles in the maintenance of brain homeostasis. The dysfunction of these cells is widely associated with brain disorders, which are often characterized by variations in the astrocyte protein markers GFAP and S100…
View article: How S100B crosses brain barriers and why it is considered a peripheral marker of brain injury
How S100B crosses brain barriers and why it is considered a peripheral marker of brain injury Open
S100B is a 21-kDa protein that is produced and secreted by astrocytes and widely used as a marker of brain injury in clinical and experimental studies. The majority of these studies are based on measurements in blood serum, assuming an ass…
View article: Astroglial S100B Secretion Is Mediated by Ca2+ Mobilization from Endoplasmic Reticulum: A Study Using Forskolin and DMSO as Secretagogues
Astroglial S100B Secretion Is Mediated by Ca2+ Mobilization from Endoplasmic Reticulum: A Study Using Forskolin and DMSO as Secretagogues Open
S100B, a homodimeric Ca2+-binding protein, is produced and secreted by astrocytes, and its extracellular levels have been used as a glial marker in brain damage and neurodegenerative and psychiatric diseases; however, its mechanism of secr…
View article: Arundic acid (ONO-2526) inhibits stimulated-S100B secretion in inflammatory conditions
Arundic acid (ONO-2526) inhibits stimulated-S100B secretion in inflammatory conditions Open
Astrocytes respond to injury by modifying the expression profile of several proteins, including the S100 calcium-binding protein B (S100B), assumed to be a marker as well as a mediator of brain injury. AA is an inhibitor of S100B synthesis…
View article: Glycolysis-Derived Compounds From Astrocytes That Modulate Synaptic Communication
Glycolysis-Derived Compounds From Astrocytes That Modulate Synaptic Communication Open
Based on the concept of the tripartite synapse, we have reviewed the role of glucose-derived compounds in glycolytic pathways in astroglial cells. Glucose provides energy and substrate replenishment for brain activity, such as glutamate an…
View article: Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis
Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis Open
View article: Additional file 2: of Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis
Additional file 2: of Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis Open
Table S1. Behavior resumed. Epilepsy behavioral evaluation of SE animals. Evaluation of the occurrence of spontaneous epileptic seizures in animals submitted to the epilepsy model by Li-pilocarpine administration. Dexamethasone did not pre…
View article: Homocysteine as a peripheral biomarker in bipolar disorder: A meta-analysis
Homocysteine as a peripheral biomarker in bipolar disorder: A meta-analysis Open
Background: Bipolar disorder (BD) is a psychiatric disorder with an uncertain aetiology. Recently, special attention has been given to homocysteine (Hcy), as it has been suggested that alterations in 1-carbon metabolism might be implicated…
View article: Methylglyoxal Induces Changes in the Glyoxalase System and Impairs Glutamate Uptake Activity in Primary Astrocytes
Methylglyoxal Induces Changes in the Glyoxalase System and Impairs Glutamate Uptake Activity in Primary Astrocytes Open
The impairment of astrocyte functions is associated with diabetes mellitus and other neurodegenerative diseases. Astrocytes have been proposed to be essential cells for neuroprotection against elevated levels of methylglyoxal (MG), a highl…
View article: Time‐dependent uptake and trafficking of vesicles capturing extracellular S100B in cultured rat astrocytes
Time‐dependent uptake and trafficking of vesicles capturing extracellular S100B in cultured rat astrocytes Open
Astrocytes, the most heterogeneous glial cells in the central nervous system, contribute to brain homeostasis, by regulating a myriad of functions, including the clearance of extracellular debris. When cells are damaged, cytoplasmic protei…
View article: Effects of ammonia and antioxidants on NO levels.
Effects of ammonia and antioxidants on NO levels. Open
The production of NO was indirectly measured by the formation of nitrite. Cells were incubated for 24 h with 100 µM resveratrol (RSV) or 500 µM L-NAME in the presence or absence of 5 mM ammonia (A). Cells were treated with 40 µM SNP…
View article: Striatal Injury with 6-OHDA Transiently Increases Cerebrospinal GFAP and S100B
Striatal Injury with 6-OHDA Transiently Increases Cerebrospinal GFAP and S100B Open
Both glial fibrillary acidic protein (GFAP) and S100B have been used as markers of astroglial plasticity, particularly in brain injury; however, they do not necessarily change in the same time frame or direction. Herein, we induced a Parki…