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View article: Correlative imaging integrates electrophysiology with three-dimensional murine heart reconstruction to reveal electrical coupling between cell types
Correlative imaging integrates electrophysiology with three-dimensional murine heart reconstruction to reveal electrical coupling between cell types Open
Cardiac fibrosis contributes to electrical conduction disturbances, yet its specific impact on conduction remains unclear, hindering predictive insight into cardiac electrophysiology and arrhythmogenesis. Arrhythmogenic cardiomyopathy is a…
View article: Clinical validation of in-silico pace-mapping for non-invasive guidance in ablation planning
Clinical validation of in-silico pace-mapping for non-invasive guidance in ablation planning Open
Background In-silico pace-mapping uses a patient-specific computational model alongside the patient’s ECG to generate a 'virtual' fully 3D pace map for guiding ablation therapy. Whilst a promising pre-procedural tool to optimize treatment,…
View article: The use of LGE-derived 3D scar metrics to predict ICD therapy in ischemic cardiomyopathy patients
The use of LGE-derived 3D scar metrics to predict ICD therapy in ischemic cardiomyopathy patients Open
Background Implantable cardioverter-defibrillators (ICDs) play a vital role in the management of ventricular arrhythmias (VAs). To improve arrhythmia risk-stratification, late gadolinium enhancement (LGE) imaging can be used to identify an…
View article: Clinical validation of simulated VT morphologies with clinical ECGs demonstrates the potential of in-silico approaches for ablation guidance
Clinical validation of simulated VT morphologies with clinical ECGs demonstrates the potential of in-silico approaches for ablation guidance Open
Background Personalized computational 'digital twin' approaches integrate detailed structural data from patient imaging with functional physiological models, enabling the simulation of realistic cardiac electrophysiological dynamics. These…
View article: Reconstructed scar morphology in patient-specific computational heart models has limited impact on the identification of ablation targets through in-silico pace mapping
Reconstructed scar morphology in patient-specific computational heart models has limited impact on the identification of ablation targets through in-silico pace mapping Open
In-silico pace mapping provides a reliable method for identifying VT ablation targets, showing relative insensitivity to scar reconstruction quality. This advantage may support its clinical translation over methods requiring explicit VT si…
View article: Optimizing ventricular scar characterization in late-gadolinium enhancement cardiac MRI: Impact of thresholding techniques in magnitude and phase-sensitive reconstructed images
Optimizing ventricular scar characterization in late-gadolinium enhancement cardiac MRI: Impact of thresholding techniques in magnitude and phase-sensitive reconstructed images Open
This study demonstrates significant differences in myocardial scar metrics based on reconstruction and thresholding techniques. PSIR consistently provided robust scar characterization across methods, emphasizing its clinical potential to s…
View article: Cardiac fibrosis affects electrical conduction and arrhythmogenesis in a pacing-rate-dependent manner
Cardiac fibrosis affects electrical conduction and arrhythmogenesis in a pacing-rate-dependent manner Open
Cardiac fibrosis is a key factor in electrical conduction disturbances, yet its specific impact on conduction remains unclear, hindering predictive insight of cardiac electrophysiology and arrhythmogenesis. Among the different cardiac diso…
View article: In silico pace mapping identifies pacing sites more accurately than inverse body surface potential mapping
In silico pace mapping identifies pacing sites more accurately than inverse body surface potential mapping Open
In silico pace mapping is more accurate than ECGi in detecting paced activation. Performance was optimal when all BSPs were used and reduced during RV apical pacing.
View article: Optimizing ventricular tachycardia ablation through imaging-based assessment of arrhythmic substrate: A comprehensive review and roadmap for the future
Optimizing ventricular tachycardia ablation through imaging-based assessment of arrhythmic substrate: A comprehensive review and roadmap for the future Open
Ventricular tachycardia (VT) is a life-threatening heart rhythm and has long posed a complex challenge in the field of cardiology. Recent developments in advanced imaging modalities have aimed to improve comprehension of underlying arrhyth…
View article: Impact of phase-correction of late-gadolinium enhancement images on quantification of scar metrics and in-silico VT-modelling in patients with an ischemic cardiomyopathy
Impact of phase-correction of late-gadolinium enhancement images on quantification of scar metrics and in-silico VT-modelling in patients with an ischemic cardiomyopathy Open
Background Late gadolinium enhancement (LGE) is used to perform tissue characterization and has become the cornerstone to guide treatment of ventricular tachyarrhythmia (VT). Traditionally, LGE acquisition is reconstructed in two distinct …
View article: Arrhythmogenic vulnerability of re-entrant pathways in post-infarct ventricular tachycardia assessed by advanced computational modelling
Arrhythmogenic vulnerability of re-entrant pathways in post-infarct ventricular tachycardia assessed by advanced computational modelling Open
Aims Substrate assessment of scar-mediated ventricular tachycardia (VT) is frequently performed using late gadolinium enhancement (LGE) images. Although this provides structural information about critical pathways through the scar, assessi…
View article: 3D substrate complexity analysis using cardiac MRI predicts ICD therapy in post-infarct ventricular tachycardia
3D substrate complexity analysis using cardiac MRI predicts ICD therapy in post-infarct ventricular tachycardia Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): EACVI, Netherlands Heart Institute. Background Implantable cardiac defibrillator (ICD) implantation can protect against sudden cardiac death (SCD) after …
View article: Additional coils mitigate elevated defibrillation threshold in right-sided implantable cardioverter defibrillator generator placement: a simulation study
Additional coils mitigate elevated defibrillation threshold in right-sided implantable cardioverter defibrillator generator placement: a simulation study Open
Aims The standard implantable cardioverter defibrillator (ICD) generator (can) is placed in the left pectoral area; however, in certain circumstances, right-sided cans may be required which may increase defibrillation threshold (DFT) due t…
View article: Predicting ICD therapy and post-ablation ventricular tachycardia recurrence using cardiac MRI-based advanced computational reentrant pathway analysis
Predicting ICD therapy and post-ablation ventricular tachycardia recurrence using cardiac MRI-based advanced computational reentrant pathway analysis Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): EACVI, Netherlands Heart Institute. Background MRI late gadolinium enhancement (LGE) images can provide novel insights about critical pathways through sc…
View article: Predicting ICD therapy and post-ablation ventricular tachycardia recurrence using cardiac MRI-based advanced computational reentrant pathway analysis
Predicting ICD therapy and post-ablation ventricular tachycardia recurrence using cardiac MRI-based advanced computational reentrant pathway analysis Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Netherlands Heart Institute Fellowship, CVON PREDICT2 Young Talent Program Background MRI late gadolinium enhancement (LGE) images can provide…
View article: The effect of scar imaging quality on in-silico pace-mapping of post-infarction ventricular tachycardia
The effect of scar imaging quality on in-silico pace-mapping of post-infarction ventricular tachycardia Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Wellcome Trust and British Heart Foundation. Background In-silico pacing mapping is a technique which involves using an anatomically-personalised image-b…
View article: 3D substrate complexity analysis using cardiac MRI predicts ICD therapy in post-infarct ventricular tachycardia
3D substrate complexity analysis using cardiac MRI predicts ICD therapy in post-infarct ventricular tachycardia Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): EACVI Research Grant Academy Van Leersum grant of the Academy Medical Sciences Fund (Royal Netherlands Academy of Arts & Sciences). Background…
View article: Subthreshold delayed afterdepolarizations provide an important arrhythmogenic substrate in the border zone of infarcted hearts
Subthreshold delayed afterdepolarizations provide an important arrhythmogenic substrate in the border zone of infarcted hearts Open
Sudden cardiac arrest resulting from myocardial infarction (MI) is most often due to ventricular tachycardia (VT). In the infarcted heart, VT has been shown to originate at the periphery of the scar1. Such tissue is often termed the infarc…
View article: Optimization of anti-tachycardia pacing efficacy through scar-specific delivery and minimization of re-initiation: a virtual study on a cohort of infarcted porcine hearts
Optimization of anti-tachycardia pacing efficacy through scar-specific delivery and minimization of re-initiation: a virtual study on a cohort of infarcted porcine hearts Open
Aims Anti-tachycardia pacing (ATP) is a reliable electrotherapy to painlessly terminate ventricular tachycardia (VT). However, ATP is often ineffective, particularly for fast VTs. The efficacy may be enhanced by optimized delivery closer t…
View article: An automated near-real time computational method for induction and treatment of scar-related ventricular tachycardias
An automated near-real time computational method for induction and treatment of scar-related ventricular tachycardias Open
Catheter ablation is currently the only curative treatment for scar-related ventricular tachycardias (VTs). However, not only are ablation procedures long, with relatively high risk, but success rates are punitively low, with frequent VT r…
View article: Predicting arrhythmia recurrence following catheter ablation for ventricular tachycardia using late gadolinium enhancement magnetic resonance imaging: Implications of varying scar ranges
Predicting arrhythmia recurrence following catheter ablation for ventricular tachycardia using late gadolinium enhancement magnetic resonance imaging: Implications of varying scar ranges Open
Varying PSI has a significant impact on quantification of LGE-CMR parameters and may have incremental clinical value in predicting arrhythmia recurrence. Further prospective investigation is warranted to clarify the functional implications…