Fernando Simón
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View article: Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
Fasciola hepatica juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism Open
Background The trematode Fasciola hepatica is the most widespread causative agent of fasciolosis, a parasitic disease that mainly affects humans and ruminants worldwide. During F . hepatica infection, newly excysted juveniles (FhNEJ) emerg…
View article: <i>Fasciola hepatica</i>juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism
<i>Fasciola hepatica</i>juveniles interact with the host fibrinolytic system as a potential early-stage invasion mechanism Open
Background The trematode Fasciola hepatica is the most widespread causative agent of fasciolosis, a parasitic disease that mainly affects humans and ruminants worldwide. During F. hepatica infection, newly excysted juveniles (FhNEJ) emerge…
View article: Proteomics coupled with in vitro model to study the early crosstalk occurring between newly excysted juveniles of Fasciola hepatica and host intestinal cells
Proteomics coupled with in vitro model to study the early crosstalk occurring between newly excysted juveniles of Fasciola hepatica and host intestinal cells Open
Fasciolosis caused by the trematode Fasciola hepatica is a zoonotic neglected disease affecting animals and humans worldwide. Infection occurs upon ingestion of aquatic plants or water contaminated with metacercariae. These release the new…
View article: Study of the migration of Fasciola hepatica juveniles across the intestinal barrier of the host by quantitative proteomics in an ex vivo model
Study of the migration of Fasciola hepatica juveniles across the intestinal barrier of the host by quantitative proteomics in an ex vivo model Open
Fasciola hepatica is a trematode parasite that infects animals and humans causing fasciolosis, a worldwide-distributed disease responsible for important economic losses and health problems. This disease is of growing public health concern …
View article: Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping review
Interaction of helminth parasites with the haemostatic system of their vertebrate hosts: a scoping review Open
Helminth parasitoses are among the most prevalent health issues worldwide. Their control depends largely on unravelling host–parasite interactions, including parasitic exploitation of the host haemostatic system. The present study undertak…
View article: Host-Parasite Relationships in Porcine Ascariosis: Anticoagulant Potential of the Third Larval Stage of Ascaris suum as a Possible Survival Mechanism
Host-Parasite Relationships in Porcine Ascariosis: Anticoagulant Potential of the Third Larval Stage of Ascaris suum as a Possible Survival Mechanism Open
In order to evade the response of their hosts, helminth parasites have evolved precise and highly regulated mechanisms, including migration strategies of the larval stages. In regard to porcine ascariosis caused by Ascaris suum, its infect…
View article: <i>Dirofilaria immitis</i> possesses molecules with anticoagulant properties in its excretory/secretory antigens
<i>Dirofilaria immitis</i> possesses molecules with anticoagulant properties in its excretory/secretory antigens Open
Dirofilaria immitis is a parasitic nematode that survives in the circulatory system of suitable hosts for many years, causing the most severe thromboembolisms when simultaneous death of adult worms occurs. The two main mechanisms responsib…
View article: Exposure of humans to the zoonotic nematode <i>Dirofilaria immitis</i> in Northern Portugal
Exposure of humans to the zoonotic nematode <i>Dirofilaria immitis</i> in Northern Portugal Open
Dirofilariosis caused by Dirofilaria immitis (heartworm) is a zoonosis, considered an endemic disease of dogs and cats in several countries of Western Europe, including Portugal. This study assesses the levels of D. immitis exposure in hum…
View article: Intestinal helminths in Iberian wolves (Canis lupus signatus) from Northwest Spain
Intestinal helminths in Iberian wolves (Canis lupus signatus) from Northwest Spain Open
Background: We present a study about helminth parasites in wolf ( Canis lupus signatus) from Sierra de la Culebra, a protected area in the Northwest of Spain, where is the largest population of wolves of the Spanish territory and one of th…
View article: Numerous<i>Fasciola</i>plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis
Numerous<i>Fasciola</i>plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis Open
Human fascioliasis is a worldwide, pathogenic food-borne trematodiasis. Impressive clinical pictures comprising puzzling polymorphisms, manifestation multifocality, disease evolution changes, sequelae and mortality, have been reported in p…
View article: Prevalence of heartworm in dogs and cats of Madrid, Spain
Prevalence of heartworm in dogs and cats of Madrid, Spain Open
The results point to the need for adequate prophylactic measures through the administration of macrocyclic lactones in animals living in Madrid. Veterinarians should be aware of the presence of this disease and include heartworm in the dif…
View article: The Complexity of Zoonotic Filariasis Episystem and Its Consequences: A Multidisciplinary View
The Complexity of Zoonotic Filariasis Episystem and Its Consequences: A Multidisciplinary View Open
Vector-borne transmitted helminthic zoonosis affects the health and economy of both developing and developed countries. The concept of episystem includes the set of biological, environmental, and epidemiological elements of these diseases …