Faraaz Shah
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View article: Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis
Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis Open
IMPORTANCE: The alternative complement pathway is a key component of host defense against bacteremia and other infections. However, dysregulated activation can contribute to excessive inflammation and worse clinical outcomes during bactere…
View article: Relationship Between Phenotyping and Individualized Absolute Risk Differences in Sepsis: A Secondary Analysis of Two Approaches in Two Multicenter Trials
Relationship Between Phenotyping and Individualized Absolute Risk Differences in Sepsis: A Secondary Analysis of Two Approaches in Two Multicenter Trials Open
OBJECTIVES: Sepsis trials likely include patients who vary in response to therapeutic interventions. The optimal approach to identify such differences in treatment response remains unclear. Estimating individualized absolute risk differenc…
View article: A Comparative Study on the Impact of Central and Other Types of Flail Chest on Outcome and Mortality in Chest Injury Patients
A Comparative Study on the Impact of Central and Other Types of Flail Chest on Outcome and Mortality in Chest Injury Patients Open
Background: Flail chest is the most serious form of blunt thoracic trauma, presenting with paradoxical chest wall motion and often complicated by high morbidity and mortality. The central flail chest may cause more profound respiratory com…
View article: Enhancing Weather Forecasting Accuracy: A Machine Learning Approach Using Genetic Algorithm and Random Forest
Enhancing Weather Forecasting Accuracy: A Machine Learning Approach Using Genetic Algorithm and Random Forest Open
Weather prediction plays a vital role in numerous fields, including agriculture, transportation, and emergency response. However, the intricate and nonlinear nature of atmospheric progressions makes accurate forecasting a persistent challe…
View article: Frequency of Pseudomonas in Community-Acquired Pneumonia
Frequency of Pseudomonas in Community-Acquired Pneumonia Open
Background: An emerging infection in CAP with important clinical ramifications is Pseudomonas aeruginosa. Optimizing treatment requires knowledge of its prevalence, risk factors, and antibiotic resistance. Objective: to ascertain P. aerugi…
View article: Impact of Lumateperone compared to Quetiapine on Quality of Life of Indian patients with Bipolar II depression: A post-hoc analysis of a Phase 3 study
Impact of Lumateperone compared to Quetiapine on Quality of Life of Indian patients with Bipolar II depression: A post-hoc analysis of a Phase 3 study Open
Introduction Lumateperone, an atypical antipsychotic drug approved for Bipolar II depression in 2021, has a dual mechanism of action by combination of activity at central serotonin (5-HT2A) and dopamine (D2) receptors. Objectives This post…
View article: Glucagon-Like Peptide-1 Is Prognostic of Mortality in Acute Respiratory Failure
Glucagon-Like Peptide-1 Is Prognostic of Mortality in Acute Respiratory Failure Open
OBJECTIVES: The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) have therapeutic effects in diabetes mellitus. Prior clinical studies suggest incretins are prognostic of adverse outcomes…
View article: Comparison of Debulking Regimens (EPOCH and DCEP) for the Treatment of Relapsed or Refractory Multiple Myeloma
Comparison of Debulking Regimens (EPOCH and DCEP) for the Treatment of Relapsed or Refractory Multiple Myeloma Open
Background: Despite recent advancements in management, relapsed and refractory multiple myeloma (RRMM) remains challenging to treat. At the time of aggressive relapse, a debulking regimen consisting of traditional infusional chemotherapy i…
View article: Clinical and Biologic Profiles of Patients with Acute Respiratory Distress Syndrome by Prevalence of Chronic Obstructive Pulmonary Disease or Emphysema; A Cohort Study
Clinical and Biologic Profiles of Patients with Acute Respiratory Distress Syndrome by Prevalence of Chronic Obstructive Pulmonary Disease or Emphysema; A Cohort Study Open
Introduction: Acute respiratory distress syndrome (ARDS) is a critical care disorder characterized by diffuse lung injury. The impact of pre-existing chronic obstructive pulmonary disease (COPD) or emphysema on ARDS pathogenesis is not wel…
View article: Glucocorticoid use in acute respiratory failure from pulmonary causes and association with early changes in the systemic host immune response
Glucocorticoid use in acute respiratory failure from pulmonary causes and association with early changes in the systemic host immune response Open
Background Glucocorticoids are commonly used in patients with or at-risk for acute respiratory distress syndrome (ARDS), but optimal use remains unclear despite well-conducted clinical trials. We performed a secondary analysis in patients …
View article: Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury
Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury Open
GDF15 (growth differentiation factor 15) is a stress cytokine with several proposed roles, including support of stress erythropoiesis. Higher circulating GDF15 levels are prognostic of mortality during acute respiratory distress syndrome, …
View article: Effectiveness of Corticosteroid Injections in Reducing the Intensity of Pain in Patients with Plantar Fasciitis
Effectiveness of Corticosteroid Injections in Reducing the Intensity of Pain in Patients with Plantar Fasciitis Open
Objective: To evaluate the effectiveness of corticosteroid injections in reducing the intensity of pain in patients with plantar fasciitis and assess its long-term outcomes. Methods: A prospective study was conducted on 72 patients diagnos…
View article: Noninvasive diagnosis of secondary infections in COVID-19 by sequencing of plasma microbial cell-free DNA
Noninvasive diagnosis of secondary infections in COVID-19 by sequencing of plasma microbial cell-free DNA Open
Secondary infection (SI) diagnosis in severe COVID-19 remains challenging. We correlated metagenomic sequencing of plasma microbial cell-free DNA (mcfDNA-Seq) with clinical SI assessment, immune response, and outcomes. We classified 42 COV…
View article: Persistence of pulmonary hypertension in patients undergoing ventricular assist devices and orthotopic heart transplantation
Persistence of pulmonary hypertension in patients undergoing ventricular assist devices and orthotopic heart transplantation Open
Pulmonary hypertension (PH) is common in advanced heart failure and often improves quickly after left ventricular assist device (VAD) implantation or orthotopic heart transplantation (OHT), but long‐term effects and outcomes are not well‐d…
View article: Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients.
Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients. Open
Critical illness can disrupt the composition and function of the microbiome, yet comprehensive longitudinal studies are lacking. We conducted a longitudinal analysis of oral, lung, and gut microbiota in a large cohort of 479 mechanically v…
View article: Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients
Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients Open
Critical illness can disrupt the composition and function of the microbiome, yet comprehensive longitudinal studies are lacking. We conducted a longitudinal analysis of oral, lung, and gut microbiota in a large cohort of 479 mechanically v…
View article: Trajectories of Host-Response Subphenotypes in Patients With COVID-19 Across the Spectrum of Respiratory Support
Trajectories of Host-Response Subphenotypes in Patients With COVID-19 Across the Spectrum of Respiratory Support Open
Longitudinal study of the systemic host response in COVID-19 revealed substantial and predictive interindividual variability influenced by baseline levels of respiratory support.
View article: Respiratory Fungal Communities are Associated with Systemic Inflammation and Predict Survival in Patients with Acute Respiratory Failure
Respiratory Fungal Communities are Associated with Systemic Inflammation and Predict Survival in Patients with Acute Respiratory Failure Open
Rationale Disruption of respiratory bacterial communities predicts poor clinical outcomes in critical illness; however, the role of respiratory fungal communities (mycobiome) is poorly understood. Objectives We investigated whether mycobio…
View article: The upper and lower respiratory tract microbiome in severe aspiration pneumonia
The upper and lower respiratory tract microbiome in severe aspiration pneumonia Open
Uncertainty persists whether anaerobic bacteria represent important pathogens in aspiration pneumonia. In a nested case-control study of mechanically ventilated patients classified as macro-aspiration pneumonia (MAsP, n = 56), non-macro-as…
View article: Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19
Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19 Open
Objectives To reliably quantify the radiographic severity of COVID-19 pneumonia with the Radiographic Assessment of Lung Edema (RALE) score on clinical chest X-rays among inpatients and examine the prognostic value of baseline RALE scores …
View article: Trajectories of host-response biomarkers and inflammatory subphenotypes in COVID-19 patients across the spectrum of respiratory support
Trajectories of host-response biomarkers and inflammatory subphenotypes in COVID-19 patients across the spectrum of respiratory support Open
Purpose Enhanced understanding of the dynamic changes in the dysregulated inflammatory response in COVID-19 may help improve patient selection and timing for immunomodulatory therapies. Methods We enrolled 323 COVID-19 inpatients on differ…