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Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis Open

Omid Omrani, Christiane Brenner, Feyza Cansiz, Shinya Imada, Jonas Rösler , et al. · 2025

Ageing dampens the regenerative potential of intestinal epithelium across species including humans, yet the underlying causes remain elusive. Here we characterized the temporal dynamics of regeneration following injury induced by 5-fluorou…

Lymph node environment drives FSP1 targetability in metastasizing melanoma Open

Mario Palma, Milena Chaufan, Cort B. Breuer, Sebastian Müller, Marie Sabatier , et al. · 2025

Ferroptosis has emerged as an actionable target to eliminate therapy-resistant and metastatic cancers¹. However, which ferroptosis surveillance systems may offer a therapeutic window to leverage redox maladaptation in cancer rem…

Tumor Genotype Dictates Mitochondrial and Immune Vulnerabilities in Liver Cancer Open

Gökhan Ünlü, Alon Millet, Khando Wangdu, Romain Donné, Ranya Erdal , et al. · 2025

Although oncogenic alterations influence tumor metabolism, how they impose distinct metabolic programs within a shared tissue context remains poorly defined. Here, we developed a rapid mitochondrial profiling platform to compare metabolite…

Autophagy maintains HEV identity and function during inflammation Open

Kathryn Jacobs, Yichao Hua, Achilleas Nikolakopoulos, Swati Gupta, Gerlanda Vella , et al. · 2025

Summary High endothelial venules (HEVs) play a crucial role in adaptive immune responses in secondary and tertiary lymphoid organs. They are uniquely equipped with high levels of peripheral node addressins (PNAd), harboring carbohydrate st…

ALK Inhibition Prolongs Survival in a Mouse Model of ALK-positive Anaplastic Thyroid Cancer Open

Yara Maria Machlah, Tim Brandenburg, Georg Sebastian Hönes, Sarah Theurer, Adrian D Prinz , et al. · 2025

Background Anaplastic thyroid cancer (ATC) is the most aggressive thyroid cancer with a median survival of about 6 months. So far, no therapies offering a survival benefit are established. Thus, new therapeutic approaches are urgently need…

Supplemental figures from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Supplemental data file contains Table S1, S2 and Figures S1-S7

Data from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Evolutionarily conserved selenoprotein O (SELENOO) catalyzes a posttranslational protein modification known as AMPylation that is essential for the oxidative stress response in bacteria and yeast. Given that oxidative stress experienced in…

Table S3 from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Data table of AMPylated substrates identified by mass spectrometry analysis.

Figure S6 from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Supplementary Figure S6 depicts markers of subcellular fractionation used to isolate crude mitochondria.

Figure S2 from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Supplementary Figure S2 correlates SelenoO expression with survival and metastasis

Figure S1 from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Supplementary Figure S1 shows expressions of SelenoO in cancer subtypes

Figure S7 from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Supplementary Figure S7 shows mass spectra of SdhA and Aco2

Figure S4 from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Supplementary Figure S4 depicts characterization of SelenoO deficient cell lines

Figure S3 from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Supplementary Figure S3 depicts expression of SelenoO in cell lines used in this study

Figure S5 from Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2025

Supplementary Figure S5 shows redox metabolite levels in wildtype and SelenoO deficient cell lines.

Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity Open

Luiza Martins Nascentes Melo, Marie Sabatier, Vijayashree Ramesh, Krystina J. Szylo, Cameron Fraser , et al. · 2024

Evolutionarily conserved selenoprotein O (SELENOO) catalyzes a posttranslational protein modification known as AMPylation that is essential for the oxidative stress response in bacteria and yeast. Given that oxidative stress experienced in…

Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis Open

J. Phan, Brandon Chen, Zhiyu Zhao, Gabriele Allies, Antonella Iannaccone , et al. · 2024

Hematopoietic stem cells (HSCs) and erythropoiesis are activated during pregnancy and after bleeding by the derepression of retrotransposons, including endogenous retroviruses and long interspersed nuclear elements. Retrotransposon transcr…

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis Open

Alberto E. Minetti, Omid Omrani, Christiane Brenner, Gabriele Allies, Shinya Imada , et al. · 2024

Aging hampers the regenerative potential of intestinal epithelium across species including humans, yet the underlying causes remain elusive. Here, using proteomic and metabolomic profiling of intestinal tissues together with functional ass…

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease Open

Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort , et al. · 2020

Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are unclear. Here we show that macroph…

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