Jorn Fierstra
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View article: Contemporary adverse event profile of microsurgery for intracranial unruptured aneurysms in high-volume microsurgical centers: the international PRAEMIUM study
Contemporary adverse event profile of microsurgery for intracranial unruptured aneurysms in high-volume microsurgical centers: the international PRAEMIUM study Open
OBJECTIVE Objective values on procedural risk are essential to facilitate informed consent and optimize clinical decision-making in patients with unruptured intracranial aneurysms (UIAs). While robust heuristics, such as the PHASES (popula…
View article: Impact of Mixed Reality on Middle Cerebral Artery Aneurysm Clipping: Initial Experience With 25 Cases
Impact of Mixed Reality on Middle Cerebral Artery Aneurysm Clipping: Initial Experience With 25 Cases Open
BACKGROUND AND OBJECTIVES: Middle cerebral artery (MCA) intracranial aneurysms (IAs) present in different anatomic configurations and variations, making their precise preoperative study of paramount importance to tailor treatment. Surgical…
View article: Reperfusion failure after successful thrombectomy of large vessel occlusion stroke: clinical and imaging evidence
Reperfusion failure after successful thrombectomy of large vessel occlusion stroke: clinical and imaging evidence Open
Introduction Reperfusion failure (RF) describes a condition in which patients suffering a large vessel occlusion (LVO) stroke present insufficient tissue reperfusion and recovery despite optimal mechanical thrombectomy (MT) results. Approx…
View article: Surgical tumor volume reduction in patients with brain metastases: A systematic review and meta-analysis
Surgical tumor volume reduction in patients with brain metastases: A systematic review and meta-analysis Open
Although in several studies higher EOR/lower RV was associated with improved OS, evidence consists of heterogeneous cohorts and rarely includes primary tumor-specific systemic therapies or relevant confounding covariates. New studies are n…
View article: Preoperative BOLD cerebrovascular reactivity correlates with intraoperative STA-MCA bypass flow and influences postoperative CVR improvement
Preoperative BOLD cerebrovascular reactivity correlates with intraoperative STA-MCA bypass flow and influences postoperative CVR improvement Open
Introduction: The superficial temporal artery-middle cerebral artery (STA-MCA) flow augmentation bypass is effective for treating Moyamoya vasculopathy and selected cases of atherosclerotic large vessel disease. Recently, blood oxygen leve…
View article: Mixed Reality-Assisted Surgical Planning of Flow-Augmentation Extracranial-Intracranial Bypass Surgery: A Technical Note
Mixed Reality-Assisted Surgical Planning of Flow-Augmentation Extracranial-Intracranial Bypass Surgery: A Technical Note Open
Surgical planning of flow-augmentation EC-IC bypass procedures with three-dimensional interactive holograms is feasible and relatively fast. Future studies should focus more extensively on a potentially associated improvement in surgical o…
View article: The Value of Non-Invasive Optimal Vessel Analysis Quantitative Magnetic Resonance Angiography for Studying Flow and Collateral Patterns in Patients with Bilateral Carotid Steno-Occlusive Disease
The Value of Non-Invasive Optimal Vessel Analysis Quantitative Magnetic Resonance Angiography for Studying Flow and Collateral Patterns in Patients with Bilateral Carotid Steno-Occlusive Disease Open
Background/Objectives: Bilateral steno-occlusive disease of the internal carotid artery (ICA) carries an increased stroke risk with associated high morbidity and mortality. Management of these patients is often complex. In this study, we e…
View article: Flow-Augmentation Bypass Surgery: Indications and Decision-Making
Flow-Augmentation Bypass Surgery: Indications and Decision-Making Open
Flow-augmentation bypass aims to enhance blood flow to hypoperfused brain regions in patients with cerebrovascular steno-occlusive diseases. This surgical procedure is indicated for ischemic and hemorrhagic moyamoya vasculopathy and for se…
View article: Correlation between P2-PCA Volume Flow Rate and BOLD Cerebrovascular Reactivity in Patients with Symptomatic Carotid Artery Occlusion
Correlation between P2-PCA Volume Flow Rate and BOLD Cerebrovascular Reactivity in Patients with Symptomatic Carotid Artery Occlusion Open
This correlation suggests that impaired BOLD-CVR is partly linked to an increased PCA-P2 volume flow rate, potentially indicating the activation of leptomeningeal collaterals in severe hemodynamic conditions. Both imaging techniques could …
View article: Correlation between nova volume flow rate and TOF signal intensity ratio: value in unilateral internal carotid artery occlusion
Correlation between nova volume flow rate and TOF signal intensity ratio: value in unilateral internal carotid artery occlusion Open
Background and purposes Non-invasive optimal vessel analysis quantitative magnetic resonance angiography (NOVA-QMRA) has emerged as a valuable tool to characterize cerebral hemodynamics in intracranial atherosclerotic disease (ICAD). Our a…
View article: NIMG-23. A NOVEL APPROACH TO PERFUSION MRI STUDIES IN BRAIN TUMOR PATIENTS USING ENDOGENOUS DEOXYHEMOGLOBIN AS A CONTRAST AGENT: A PROOF-OF-CONCEPT STUDY
NIMG-23. A NOVEL APPROACH TO PERFUSION MRI STUDIES IN BRAIN TUMOR PATIENTS USING ENDOGENOUS DEOXYHEMOGLOBIN AS A CONTRAST AGENT: A PROOF-OF-CONCEPT STUDY Open
BACKGROUND Assessment of resting perfusion in brain tumors is clinically relevant and relies on dynamic susceptibility contrast magnetic resonance imaging using gadolinium contrast. Preliminary studies have introduced the use of controlled…
View article: NIMG-26. GLIOBLASTOMA TISSUE INVASION MAPPING WITH NOVEL HYPOXIA-TARGETED BLOOD OXYGENATION-LEVEL DEPENDENT MRI
NIMG-26. GLIOBLASTOMA TISSUE INVASION MAPPING WITH NOVEL HYPOXIA-TARGETED BLOOD OXYGENATION-LEVEL DEPENDENT MRI Open
BACKGROUND Glioblastoma is a devastating incurable malignant primary brain tumor exhibiting an erratic growth pattern and brain tissue invasion exceeding the typically depicted contrast-enhancing lesion on MRI. This behaviour is strongly a…
View article: BOLD Cerebrovascular Reactivity and NOVA Quantitative MR Angiography in Adult Patients with Moyamoya Vasculopathy Undergoing Cerebral Bypass Surgery
BOLD Cerebrovascular Reactivity and NOVA Quantitative MR Angiography in Adult Patients with Moyamoya Vasculopathy Undergoing Cerebral Bypass Surgery Open
Revascularization surgery for the symptomatic hemisphere with hemodynamic impairment is effective for Moyamoya vasculopathy patients. However, careful patient selection is crucial and ideally supported by advanced quantitative hemodynamic …
View article: Hemodynamic Stroke: Emerging Concepts, Risk Estimation, and Treatment
Hemodynamic Stroke: Emerging Concepts, Risk Estimation, and Treatment Open
Ischemic stroke can arise from the sudden occlusion of a brain-feeding artery by a clot (embolic), or local thrombosis. Hemodynamic stroke occurs when blood flow does not sufficiently meet the metabolic demand of a brain region at a certai…
View article: Role of microsurgical tumor burden reduction in patients with breast cancer brain metastases considering molecular subtypes: a two-center volumetric survival analysis
Role of microsurgical tumor burden reduction in patients with breast cancer brain metastases considering molecular subtypes: a two-center volumetric survival analysis Open
Background Advancements in metastatic breast cancer (BC) treatment have enhanced overall survival (OS), leading to increased rates of brain metastases (BM). This study analyzes the association between microsurgical tumor reduction and OS i…
View article: The volume of steal phenomenon is associated with neurological deterioration in patients with large-vessel occlusion minor stroke not eligible for thrombectomy
The volume of steal phenomenon is associated with neurological deterioration in patients with large-vessel occlusion minor stroke not eligible for thrombectomy Open
Introduction: A significant number of patients who present with mild symptoms following large-vessel occlusion acute ischemic stroke (LVO-AIS) are currently considered ineligible for EVT. However, they frequently experience neurological de…
View article: Transient deoxyhemoglobin formation as a contrast for perfusion MRI studies in patients with brain tumors: a feasibility study
Transient deoxyhemoglobin formation as a contrast for perfusion MRI studies in patients with brain tumors: a feasibility study Open
Background: Transient hypoxia-induced deoxyhemoglobin (dOHb) has recently been shown to represent a comparable contrast to gadolinium-based contrast agents for generating resting perfusion measures in healthy subjects. Here, we investigate…
View article: Flow-augmentation STA-MCA bypass for acute and subacute ischemic stroke due to internal carotid artery occlusion and the role of advanced neuroimaging with hemodynamic and flow-measurement in the decision-making: preliminary data
Flow-augmentation STA-MCA bypass for acute and subacute ischemic stroke due to internal carotid artery occlusion and the role of advanced neuroimaging with hemodynamic and flow-measurement in the decision-making: preliminary data Open
Quantitative assessment with BOLD-CVR and qMRA-NOVA allows us to evaluate the pre- and post-operative cerebral hemodynamics and collateral vessel status in patients with acute/subacute stroke due to ICA occlusion who may benefit from surgi…