Filip Braet
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View article: ScSAM: Debiasing Morphology and Distributional Variability in Subcellular Semantic Segmentation
ScSAM: Debiasing Morphology and Distributional Variability in Subcellular Semantic Segmentation Open
The significant morphological and distributional variability among subcellular components poses a long-standing challenge for learning-based organelle segmentation models, significantly increasing the risk of biased feature learning. Exist…
View article: Bring your paper into the ‘Fast Lane’ of the editorial process and increase your changes for final acceptance in Micron, The International Research and Review Journal for Microscopy – Part II
Bring your paper into the ‘Fast Lane’ of the editorial process and increase your changes for final acceptance in Micron, The International Research and Review Journal for Microscopy – Part II Open
It has been ten years since the Editors of Micron contributed an editorial offering tips and tricks to help potential contributors navigate the editorial process and improve their chances of manuscript acceptance. In this contribution, we …
View article: Revisiting Adaptive Cellular Recognition Under Domain Shifts: A Contextual Correspondence View
Revisiting Adaptive Cellular Recognition Under Domain Shifts: A Contextual Correspondence View Open
Cellular nuclei recognition serves as a fundamental and essential step in the workflow of digital pathology. However, with disparate source organs and staining procedures among histology image clusters, the scanned tiles inherently conform…
View article: Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus
Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus Open
Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global importance. Asexual blood stage replication, via a process called schizogony, is an important target for the development of new antimalarials. Here we…
View article: TOC ‐ Issue Information
TOC ‐ Issue Information Open
It publishes papers that report on the very latest developments in microscopy such as advances in microscopy techniques or novel areas of application.The Journal does not seek to publish routine applications of microscopy or specimen prepa…
View article: Plasmodium falciparum kinetochore proteins stabilise a nexus between the mitotic apparatus and the apical complex
Plasmodium falciparum kinetochore proteins stabilise a nexus between the mitotic apparatus and the apical complex Open
Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global importance. Asexual blood stage replication, via a process called schizogony, is an important target for the development of new antimalarials. Here we…
View article: Let's have a chat about chatbot(s) in (biological) microscopy
Let's have a chat about chatbot(s) in (biological) microscopy Open
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View article: Giant mitochondria in human liver disease
Giant mitochondria in human liver disease Open
This thematic review aims to provide an overview of the current state of knowledge about the occurrence of giant mitochondria or megamitochondria in liver parenchymal cells. Their presence and accumulation are considered to be a major path…
View article: Transcriptomic Comparison of Human Peripartum and Dilated Cardiomyopathy Identifies Differences in Key Disease Pathways
Transcriptomic Comparison of Human Peripartum and Dilated Cardiomyopathy Identifies Differences in Key Disease Pathways Open
Peripartum cardiomyopathy (PPCM) is a rare form of acute onset heart failure that presents in otherwise healthy pregnant women around the time of delivery. While most of these women respond to early intervention, about 20% progress to end-…
View article: Big data in contemporary electron microscopy: challenges and opportunities in data transfer, compute and management
Big data in contemporary electron microscopy: challenges and opportunities in data transfer, compute and management Open
The second decade of the twenty-first century witnessed a new challenge in the handling of microscopy data. Big data, data deluge, large data, data compliance, data analytics, data integrity, data interoperability, data retention and data …
View article: From Microenvironment Remediation to Novel Anti-Cancer Strategy: The Emergence of Zero Valent Iron Nanoparticles
From Microenvironment Remediation to Novel Anti-Cancer Strategy: The Emergence of Zero Valent Iron Nanoparticles Open
Accumulated studies indicate that zero-valent iron (ZVI) nanoparticles demonstrate endogenous cancer-selective cytotoxicity, without any external electric field, lights, or energy, while sparing healthy non-cancerous cells in vitro and in …
View article: KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease
KCa3.1 Mediates Dysregulation of Mitochondrial Quality Control in Diabetic Kidney Disease Open
Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease. Mitochondrial quality control is primarily mediated by mitochondrial turnover and repair through mitochondrial fission/fusion and mitophagy. We have pr…
View article: Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems
Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems Open
Significance Myosin-binding protein C (MyBP-C) is a critical component of the skeletal muscle sarcomere, muscle’s smallest contractile unit. MyBP-C’s importance is evident by genetic mutations leading to human myopathies, such as distal ar…
View article: Actin‐spectrin scaffold supports open fenestrae in liver sinusoidal endothelial cells
Actin‐spectrin scaffold supports open fenestrae in liver sinusoidal endothelial cells Open
Fenestrae are open transmembrane pores that are a structural hallmark of healthy liver sinusoidal endothelial cells (LSECs). Their key role is the transport of solutes and macromolecular complexes between the sinusoidal lumen and the space…
View article: SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS
SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS Open
Skeletal muscle myosin-binding protein C (MyBP-C) is a myosin thick filament-associated protein; localized through its C terminus to distinct regions (C-zones) of the sarcomere. MyBP-C modulates muscle contractility, presumably through its…
View article: Characterization of Iron Core–Gold Shell Nanoparticles for Anti-Cancer Treatments: Chemical and Structural Transformations During Storage and Use
Characterization of Iron Core–Gold Shell Nanoparticles for Anti-Cancer Treatments: Chemical and Structural Transformations During Storage and Use Open
Finding a cancer-selective drug that avoids damaging healthy cells and organs is a holy grail in medical research. In our previous studies, gold-coated iron (Fe@Au) nanoparticles showed cancer selective anti-cancer properties in vitro and …
View article: Tracking Fenestrae Dynamics in Live Murine Liver Sinusoidal Endothelial Cells
Tracking Fenestrae Dynamics in Live Murine Liver Sinusoidal Endothelial Cells Open
The fenestrae of liver sinusoidal endothelial cells (LSECs) allow passive transport of solutes, macromolecules, and particulate material between the sinusoidal lumen and the liver parenchymal cells. Until recently, fenestrae and fenestrae‐…
View article: A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance
A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance Open
Background Truncating variants in the TTN gene ( TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestat…
View article: Cannabinoid-induced increase of quantal size and enhanced neuromuscular transmission
Cannabinoid-induced increase of quantal size and enhanced neuromuscular transmission Open
Cannabinoids exert dynamic control over many physiological processes including memory formation, cognition and pain perception. In the central nervous system endocannabinoids mediate negative feedback of quantal transmitter release followi…