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View article: Sarcopenia—A Valuable Imaging Biomarker for Disease Progression in Patients With Primary Sclerosing Cholangitis (PSC)?
Sarcopenia—A Valuable Imaging Biomarker for Disease Progression in Patients With Primary Sclerosing Cholangitis (PSC)? Open
Background and Aims We aimed to ascertain the prevalence of sarcopenia in patients with primary sclerosing cholangitis (PSC) and to assess the prognostic value as a biomarker for disease outcome. Methods We collected data from 224 patients…
View article: Dual‐Center Repeatability, Consistency, and Comparison of 3D Phase‐Resolved Functional (PREFUL) Ventilation MRI at 3 and 1.5 T in Healthy Volunteers
Dual‐Center Repeatability, Consistency, and Comparison of 3D Phase‐Resolved Functional (PREFUL) Ventilation MRI at 3 and 1.5 T in Healthy Volunteers Open
3D phase‐resolved functional lung (PREFUL) MRI offers lung ventilation assessment without contrast and in free breathing. However, there are limited data on its repeatability and intercenter consistency. This study aimed to assess the repe…
View article: Phase-Resolved Functional Lung MRI Evaluation of Dynamic Hyperinflation Induced by Metronome-Paced Tachypnea in Patients with Chronic Obstructive Pulmonary Disease
Phase-Resolved Functional Lung MRI Evaluation of Dynamic Hyperinflation Induced by Metronome-Paced Tachypnea in Patients with Chronic Obstructive Pulmonary Disease Open
Hyperinflation in chronic obstructive pulmonary disease (COPD) patients worsens on exertion/exercise when breathing frequency increases. Fast breathing, paced at 40 breaths per minute using a metronome (metronome-paced tachypnea, MPT), ind…
View article: Functional Pulmonary Imaging
Functional Pulmonary Imaging Open
The aging of the world population gave rise to an increased prevalence of many lung diseases, with chronic obstructive pulmonary disease now ranking as the third‐leading cause of death according to the World Health Organization. To diagnos…
View article: Wasted ventilation in mild COPD: protocol for a clinical physiology and functional imaging study
Wasted ventilation in mild COPD: protocol for a clinical physiology and functional imaging study Open
Background High ventilation–CO 2 output, signaling increased wasted ventilation in the physiological dead space ( V D phys ), has a dominant role in eliciting activity-related dyspnoea in subjects with COPD showing only mild airflow obstru…
View article: Quantifying spatial and dynamic lung abnormalities with <scp>3D PREFUL FLORET UTE</scp> imaging: A feasibility study
Quantifying spatial and dynamic lung abnormalities with <span>3D PREFUL FLORET UTE</span> imaging: A feasibility study Open
Purpose Pulmonary MRI faces challenges due to low proton density, rapid transverse magnetization decay, and cardiac and respiratory motion. The fermat‐looped orthogonally encoded trajectories (FLORET) sequence addresses these issues with h…
View article: Comparison of AI software tools for automated detection, quantification and categorization of pulmonary nodules in the HANSE LCS trial
Comparison of AI software tools for automated detection, quantification and categorization of pulmonary nodules in the HANSE LCS trial Open
Participant management in a lung cancer screening (LCS) depends on the assigned Lung Imaging Reporting and Data System (Lung-RADS) category, which is based on reliable detection and measurement of pulmonary nodules. The aim of this study w…
View article: Influence of echo time on pulmonary ventilation and perfusion derived by phase‐resolved functional lung (PREFUL) MRI using multi‐echo ultrashort echo time acquisition
Influence of echo time on pulmonary ventilation and perfusion derived by phase‐resolved functional lung (PREFUL) MRI using multi‐echo ultrashort echo time acquisition Open
Non‐contrast enhanced 1 H magnetic resonance imaging (MRI) is promising for ventilation/perfusion (V/Q) assessment of the lung but the influence of the echo time (TE) on V/Q parameters is lacking. Therefore, the purpose of this study was t…
View article: A synthetic lung model (ASYLUM) for validation of functional lung imaging methods shows significant differences between signal-based and deformation-field-based ventilation measurements
A synthetic lung model (ASYLUM) for validation of functional lung imaging methods shows significant differences between signal-based and deformation-field-based ventilation measurements Open
Introduction Validation of functional free-breathing MRI involves a comparison to more established or more direct measurements. This procedure is cost-intensive, as it requires access to patient cohorts, lengthy protocols, expenses for con…
View article: Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized 129Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers
Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized 129Xe ventilation MRI in patients with chronic obstructive pulmonary disease and healthy volunteers Open
View article: Sequence comparison of spoiled gradient echo and balanced steady‐state free precession for pulmonary free‐breathing proton MRI in patients and healthy volunteers: Correspondence, repeatability, and validation with dynamic contrast‐enhanced MRI
Sequence comparison of spoiled gradient echo and balanced steady‐state free precession for pulmonary free‐breathing proton MRI in patients and healthy volunteers: Correspondence, repeatability, and validation with dynamic contrast‐enhanced MRI Open
Phase‐resolved functional lung (PREFUL) MRI is a proton‐based, contrast agent‐free technique derived from the Fourier decomposition approach to measure regional ventilation and perfusion dynamics during free‐breathing. Besides the necessit…
View article: Doppler‐derived pulmonary pulse transit time measurements in chronic obstructive pulmonary disease: Reproducibility and cardiopulmonary function
Doppler‐derived pulmonary pulse transit time measurements in chronic obstructive pulmonary disease: Reproducibility and cardiopulmonary function Open
Introduction Doppler‐derived pulmonary pulse transit time (pPTT) is an auspicious hemodynamic marker in chronic pulmonary diseases. The aim is to compare four distinct pPTT measurements and its relation to right cardiac and pulmonary funct…
View article: Estimation of Cerebral Blood Flow Using the Pulse Wave Amplitude in Brain MRI
Estimation of Cerebral Blood Flow Using the Pulse Wave Amplitude in Brain MRI Open
In conclusion, the proposed technique allows a rough approximation of the CBF compared to pCASL-MRI. Further sequence optimization must be achieved to improve the measurement of relatively lowly perfused tissues. Nevertheless, it offers la…
View article: PREFUL MRI for Monitoring Perfusion and Ventilation Changes after Elexacaftor-Tezacaftor-Ivacaftor Therapy for Cystic Fibrosis: A Feasibility Study
PREFUL MRI for Monitoring Perfusion and Ventilation Changes after Elexacaftor-Tezacaftor-Ivacaftor Therapy for Cystic Fibrosis: A Feasibility Study Open
Purpose To assess the feasibility of monitoring the effects of elexacaftor-tezacaftor-ivacaftor (ETI) therapy on lung ventilation and perfusion in people with cystic fibrosis (CF), using phase-resolved functional lung (PREFUL) MRI. Materia…
View article: Feasibility, Repeatability, and Correlation to Lung Function of Phase‐Resolved Functional Lung (<scp>PREFUL</scp>) <scp>MRI</scp>‐derived Pulmonary Artery Pulse Wave Velocity Measurements
Feasibility, Repeatability, and Correlation to Lung Function of Phase‐Resolved Functional Lung (<span>PREFUL</span>) <span>MRI</span>‐derived Pulmonary Artery Pulse Wave Velocity Measurements Open
Background Pulse wave velocity (PWV) in the pulmonary arteries (PA) is a marker of vascular stiffening. Currently, only phase‐contrast (PC) MRI‐based options exist to measure PA‐PWV. Purpose To test feasibility, repeatability, and correlat…
View article: Alveolar membrane and capillary function in COVID-19 convalescents: insights from chest MRI
Alveolar membrane and capillary function in COVID-19 convalescents: insights from chest MRI Open
Objectives To investigate potential presence and resolution of longer-term pulmonary diffusion limitation and microvascular perfusion impairment in COVID-19 convalescents. Materials and methods This prospective, longitudinal study was carr…
View article: Estimating ventilation correlation coefficients in the lungs using <scp>PREFUL‐MRI</scp> in <scp>chronic obstructive pulmonary disease</scp> patients and healthy adults
Estimating ventilation correlation coefficients in the lungs using <span>PREFUL‐MRI</span> in <span>chronic obstructive pulmonary disease</span> patients and healthy adults Open
Purpose Various parameters of regional lung ventilation can be estimated using phase‐resolved functional lung (PREFUL)‐MRI. The parameter “ventilation correlation coefficient (Vent‐CC)” was shown advantageous because it assesses the dynami…
View article: Comparison of Free‐Breathing <scp>3D</scp> Phase‐Resolved Functional Lung (<scp>PREFUL</scp>) <scp>MRI</scp> With Dynamic <scp><sup>19</sup>F</scp> Ventilation <scp>MRI</scp> in Patients With Obstructive Lung Disease and Healthy Volunteers
Comparison of Free‐Breathing <span>3D</span> Phase‐Resolved Functional Lung (<span>PREFUL</span>) <span>MRI</span> With Dynamic <span><sup>19</sup>F</span> Ventilation <span>MRI</span> in Patients With Obstructive Lung Disease and Healthy Volunteers Open
Background Non‐contrast‐enhanced 1 H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional lung ventilation but a comparison with direct ventilation measurement using 19 F MRI is lacking. Purpose…
View article: Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI
Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI Open
To analyze cerebral arteriovenous pulse propagation and to generate phase-resolved pulse amplitude maps from a fast gradient-echo sequence offering flow-related enhancement (FREE). Brain MRI was performed using a balanced steady-state free…
View article: Comparison of AI software tools for automated detection, quantification and categorization of pulmonary nodules in the HANSE LCS trial
Comparison of AI software tools for automated detection, quantification and categorization of pulmonary nodules in the HANSE LCS trial Open
Purpose To compare the performance of two AI-based software tools for detection, quantification and categorization of pulmonary nodules in a lung cancer screening (LCS) program in Northern Germany (HANSE-trial). Method 946 low-dose baselin…
View article: Effect of CFTR modulator therapy with elexacaftor/tezacaftor/ivacaftor on pulmonary ventilation derived by 3D phase-resolved functional lung MRI in cystic fibrosis patients
Effect of CFTR modulator therapy with elexacaftor/tezacaftor/ivacaftor on pulmonary ventilation derived by 3D phase-resolved functional lung MRI in cystic fibrosis patients Open
View article: Influence of gadolinium, field-strength and sequence type on quantified perfusion values in phase-resolved functional lung MRI
Influence of gadolinium, field-strength and sequence type on quantified perfusion values in phase-resolved functional lung MRI Open
Purpose The purpose of this study is to evaluate the influences of gadolinium-based contrast agents, field-strength and different sequences on perfusion quantification in Phase-Resolved Functional Lung (PREFUL) MRI. Materials and methods F…
View article: Artificially-generated consolidations and balanced augmentation increase performance of U-net for lung parenchyma segmentation on MR images
Artificially-generated consolidations and balanced augmentation increase performance of U-net for lung parenchyma segmentation on MR images Open
Purpose To improve automated lung segmentation on 2D lung MR images using balanced augmentation and artificially-generated consolidations for training of a convolutional neural network (CNN). Materials and methods From 233 healthy voluntee…
View article: Feasibility of flow-related enhancement brain perfusion MRI
Feasibility of flow-related enhancement brain perfusion MRI Open
Purpose Brain perfusion imaging is of enormous importance for various neurological diseases. Fast gradient-echo sequences offering flow-related enhancement (FREE) could present a basis to generate perfusion-weighted maps. In this study, we…
View article: Evaluation of image registration algorithms for 3D phase‐resolved functional lung ventilation magnetic resonance imaging in healthy volunteers and chronic obstructive pulmonary disease patients
Evaluation of image registration algorithms for 3D phase‐resolved functional lung ventilation magnetic resonance imaging in healthy volunteers and chronic obstructive pulmonary disease patients Open
The purpose of the current study was to assess the influence of the registration algorithms on the repeatability of three‐dimensional (3D) phase‐resolved functional lung (PREFUL) ventilation magnetic resonance imaging (MRI). Twenty‐three h…
View article: Evaluation of tissue shrinkage after CT-guided microwave ablation in patients with liver malignancies using Jacobian determinant
Evaluation of tissue shrinkage after CT-guided microwave ablation in patients with liver malignancies using Jacobian determinant Open
3D Jacobian analysis shows that hepatic tissue deformation following MWA is most pronounced in a 5-cm area surrounding the treated tumor. Tumor location and tumor volume may have an impact on the extent of tissue shrinkage which may affect…
View article: PREFUL MRI Depicts Dual Bronchodilator Changes in COPD: A Retrospective Analysis of a Randomized Controlled Trial
PREFUL MRI Depicts Dual Bronchodilator Changes in COPD: A Retrospective Analysis of a Randomized Controlled Trial Open
Regional ventilation dynamics and VQM measured by PREFUL MRI show treatment response in COPD. Supplemental material is available for this article. Clinical trial registration no. NTR6831Keywords: MRI, COPD, Perfusion, Ventila…
View article: A dual center and dual vendor comparison study of automated perfusion‐weighted phase‐resolved functional lung magnetic resonance imaging with dynamic contrast‐enhanced magnetic resonance imaging in patients with cystic fibrosis
A dual center and dual vendor comparison study of automated perfusion‐weighted phase‐resolved functional lung magnetic resonance imaging with dynamic contrast‐enhanced magnetic resonance imaging in patients with cystic fibrosis Open
For sensitive diagnosis and monitoring of pulmonary disease, ionizing radiation‐free imaging methods are of great importance. A noncontrast and free‐breathing proton magnetic resonance imaging (MRI) technique for assessment of pulmonary pe…
View article: Validation of Phase‐Resolved Functional Lung (PREFUL) Magnetic Resonance Imaging Pulse Wave Transit Time Compared to Echocardiography in Chronic Obstructive Pulmonary Disease
Validation of Phase‐Resolved Functional Lung (PREFUL) Magnetic Resonance Imaging Pulse Wave Transit Time Compared to Echocardiography in Chronic Obstructive Pulmonary Disease Open
Background Phase‐resolved functional lung (PREFUL) magnetic resonance imaging (MRI) pulmonary pulse wave transit time (pPTT) is a contrast agent free, vascular imaging biomarker, but has not been validated in chronic obstructive pulmonary …
View article: High resolution flat-panel CT arthrography vs. MR arthrography of artificially created osteochondral defects in ex vivo upper ankle joints
High resolution flat-panel CT arthrography vs. MR arthrography of artificially created osteochondral defects in ex vivo upper ankle joints Open
Purpose High resolution flat-panel computed tomography arthrography (FPCT-A) and magnetic resonance arthrography (MR-A) are well suited to evaluate osteochondral lesions. The current study compares the performance of FPCT-A versus MR-A in …