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View article: Taurine Intake, Plasma Taurine Concentration, and Dementia Risk: Findings From the Malmö Diet and Cancer Study
Taurine Intake, Plasma Taurine Concentration, and Dementia Risk: Findings From the Malmö Diet and Cancer Study Open
Preclinical studies suggest that taurine may exert neuroprotective effects. However, its relevance to dementia risk in human populations remains unclear. We investigated the associations between mid‐life dietary taurine intake, circulating…
View article: Porcine model of <i>BRD1</i> haploinsufficiency reveals neurodevelopmental, behavioral, and molecular alterations relevant to psychiatric disorders
Porcine model of <i>BRD1</i> haploinsufficiency reveals neurodevelopmental, behavioral, and molecular alterations relevant to psychiatric disorders Open
Psychiatric disorders are heritable and biologically complex, with overlapping genetic architectures and shared molecular pathways. Among implicated genes, BRD1 has emerged as an epigenetic regulator of neurodevelopment with broad relevanc…
View article: High level of immunoglobulin G targeting mycoplasma or cytomegalovirus in the newborn increases risk of ADHD
High level of immunoglobulin G targeting mycoplasma or cytomegalovirus in the newborn increases risk of ADHD Open
View article: Psychometric archetypes reveal biological signatures of vulnerability, resilience, and future mental health
Psychometric archetypes reveal biological signatures of vulnerability, resilience, and future mental health Open
Background Mental health comprises emotional, psychological, and social dimensions, extending beyond the mere absence of illness. Shaped by a complex interplay of hereditary factors and life experiences, mental health can deteriorate into …
View article: Unraveling the metabolomic architecture of autism in a large Danish population-based cohort
Unraveling the metabolomic architecture of autism in a large Danish population-based cohort Open
Background The prevalence of autism in Denmark has been increasing, reaching 1.65% among 10-year-old children, and similar trends are seen elsewhere. Although there are several factors associated with autism, including genetic, environment…
View article: Plasma Metabolome Predicts Aortic Stiffness and Future Risk of Coronary Artery Disease and Mortality After 23 Years of Follow‐Up in the General Population
Plasma Metabolome Predicts Aortic Stiffness and Future Risk of Coronary Artery Disease and Mortality After 23 Years of Follow‐Up in the General Population Open
Background Increased aortic stiffness (arteriosclerosis) is associated with early vascular aging independent of age and sex. The underlying mechanisms of early vascular aging remain largely unexplored in the general population. We aimed to…
View article: The association between water intake and future cardiometabolic disease outcomes in the Malmö Diet and Cancer cardiovascular cohort
The association between water intake and future cardiometabolic disease outcomes in the Malmö Diet and Cancer cardiovascular cohort Open
The aim of this study was to explore the longitudinal association between reported baseline water intake and incidence of coronary artery disease (CAD) and type 2 diabetes in the Malmö Diet and Cancer Cohort (n = 25,369). Using cox proport…
View article: Unraveling the metabolomic architecture of autism in a large Danish population-based cohort
Unraveling the metabolomic architecture of autism in a large Danish population-based cohort Open
The prevalence of autism in Denmark has been increasing, reaching 1.65% among 10-year-old children and similar trends are seen elsewhere. Although there are several factors associated with autism, including genetic, environmental and prena…
View article: The Hitchhiker’s Guide to Statistical Analysis of Feature-based Molecular Networks from Non-Targeted Metabolomics Data
The Hitchhiker’s Guide to Statistical Analysis of Feature-based Molecular Networks from Non-Targeted Metabolomics Data Open
Feature-Based Molecular Networking (FBMN) is a popular analysis approach for LC-MS/MS-based non-targeted metabolomics data. While processing LC-MS/MS data through FBMN is fairly streamlined, downstream data handling and statistical interro…
View article: <i>Streptococcus</i> Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort
<i>Streptococcus</i> Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort Open
BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomograp…
View article: Author Correction: An online atlas of human plasma metabolite signatures of gut microbiome composition
Author Correction: An online atlas of human plasma metabolite signatures of gut microbiome composition Open
View article: Identification of biomarkers for glycaemic deterioration in type 2 diabetes
Identification of biomarkers for glycaemic deterioration in type 2 diabetes Open
View article: Effects of Long-Term Storage on the Biobanked Neonatal Dried Blood Spot Metabolome
Effects of Long-Term Storage on the Biobanked Neonatal Dried Blood Spot Metabolome Open
Over 2.5 million neonatal dried blood spots (DBS) are stored at the Danish National Biobank. These samples offer extraordinary possibilities for metabolomics research, including prediction of disease and understanding of underlying molecul…
View article: Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population
Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population Open
BACKGROUND: Albuminuria is associated with metabolic abnormalities, but these relationships are not well understood. We studied the association of metabolites with albuminuria in Hispanic/Latino people, a population with high risk for meta…
View article: Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population
Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population Open
Background Albuminuria is associated with metabolic abnormalities, but these relationships are not well understood. We studied the association of metabolites with albuminuria in Hispanic/Latino people, a population with high risk for metab…
View article: Long-term storage has minor effects on biobanked neonatal dried blood spot metabolome
Long-term storage has minor effects on biobanked neonatal dried blood spot metabolome Open
Over 2.5 million neonatal dried blood spots (DBS) are stored at the Danish National Biobank. These samples offer extraordinary possibilities for metabolomics research, including prediction of disease and understanding of underlying molecul…
View article: An online atlas of human plasma metabolite signatures of gut microbiome composition
An online atlas of human plasma metabolite signatures of gut microbiome composition Open
View article: <i>Streptococcus</i>species abundance in the gut is linked to subclinical coronary atherosclerosis in 8973 participants from the SCAPIS cohort
<i>Streptococcus</i>species abundance in the gut is linked to subclinical coronary atherosclerosis in 8973 participants from the SCAPIS cohort Open
BACKGROUND Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomograph…
View article: Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality
Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality Open
Objective Obesity is a key risk factor for type 2 diabetes, however, up to 20% of patients are normal weight. Our aim was to identify metabolite patterns reproducibly predictive of BMI, and subsequently to test if lean individuals w…
View article: Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality
Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality Open
Objective Obesity is a key risk factor for type 2 diabetes, however, up to 20% of patients are normal weight. Our aim was to identify metabolite patterns reproducibly predictive of BMI, and subsequently to test if lean individuals w…
View article: Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality
Metabolome-Defined Obesity and the Risk of Future Type 2 Diabetes and Mortality Open
OBJECTIVE Obesity is a key risk factor for type 2 diabetes; however, up to 20% of patients are normal weight. Our aim was to identify metabolite patterns reproducibly predictive of BMI and subsequently to test whether lean individuals who …
View article: The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population‐based study
The inverse association between a fish consumption biomarker and gingival inflammation and periodontitis: A population‐based study Open
Aim The metabolite 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropionic acid (CMPF) is a fatty fish–intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definit…
View article: An online atlas of human plasma metabolite signatures of gut microbiome composition
An online atlas of human plasma metabolite signatures of gut microbiome composition Open
Summary paragraph The human gut microbiota produces a variety of small compounds, some of which enter the bloodstream and impact host health. Conversely, various exogenous nutritional and pharmaceutical compounds affect the gut microbiome …
View article: Prospective Evaluation of Circulating miR-126, mir-197 and mir-223 in Relation to Cardiometabolic Diseases
Prospective Evaluation of Circulating miR-126, mir-197 and mir-223 in Relation to Cardiometabolic Diseases Open
We aim to investigate if serum levels of microRNAs: miR-126, mir-197 and mir-223, previously implicated in cardiometabolic disease, are reproducibly associated with incident-diabetes (inc-DM), incident-cardiovascular disease (inc-CVD) and …
View article: Metabolome-defined obesity and the risk of future diabetes and mortality
Metabolome-defined obesity and the risk of future diabetes and mortality Open
Background Obesity is a key risk factor for type 2 diabetes, however, up to 20% of patients are normal weight. Our aim was to identify metabolite patterns reproducibly predictive of BMI, and subsequently to test if lean individuals who car…
View article: Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study
Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study Open
We have deployed a multi-omics approach in large cohorts of patients with existing type 2 diabetes to identify biomarkers for disease progression across three molecular classes, metabolites, lipids and proteins. A Cox regression analysis f…
View article: A plasma lipid signature predicts incident coronary artery disease
A plasma lipid signature predicts incident coronary artery disease Open
A lipid pattern improve CAD prediction above traditional risk factors, highlighting that conventional lipid-measures insufficiently describe dyslipidemia that is present years before CAD. Identifying this hidden dyslipidemia may help motiv…
View article: Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation
Altered Acylcarnitine Metabolism Is Associated With an Increased Risk of Atrial Fibrillation Open
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, but the pathogenesis is not completely understood. The application of metabolomics could help in discovering new metabolic pathways involved in the development of t…
View article: The gut microbiota-related metabolite phenylacetylglutamine associates with increased risk of incident coronary artery disease
The gut microbiota-related metabolite phenylacetylglutamine associates with increased risk of incident coronary artery disease Open
Objective: The gut microbiota is increasingly being implicated in cardiovascular health. Metabolites produced by bacteria have been suggested to be mediators in the bacterial action on cardiovascular health. We aimed to identify gut microb…
View article: Dimethylguanidino Valerate: A Lifestyle‐Related Metabolite Associated With Future Coronary Artery Disease and Cardiovascular Mortality
Dimethylguanidino Valerate: A Lifestyle‐Related Metabolite Associated With Future Coronary Artery Disease and Cardiovascular Mortality Open
Background Identification of lifestyle modifiable metabolic pathways related to cardiometabolic disease risk is essential for improvement of primary prevention in susceptible individuals. It was recently shown that plasma dimethylguanidino…