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View article: Anti-elastase ANCA-associated vasculitis: a case report and literature review
Anti-elastase ANCA-associated vasculitis: a case report and literature review Open
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic necrotizing vasculitis that primarily affects small- to medium-sized vessels and represents a spectrum of diseases with overlapping clinical and immunopat…
View article: HERDEIROS DO RISCO: O PAPEL DA GENÉTICA NO RASTREAMENTO DO CÂNCER DE MAMA
HERDEIROS DO RISCO: O PAPEL DA GENÉTICA NO RASTREAMENTO DO CÂNCER DE MAMA Open
View article: Liver Cirrhosis and Outcomes in Spontaneous Intracerebral Hemorrhage
Liver Cirrhosis and Outcomes in Spontaneous Intracerebral Hemorrhage Open
View article: Insuficiência ovariana prematura: fatores causais e uma revisão da literatura
Insuficiência ovariana prematura: fatores causais e uma revisão da literatura Open
A Insuficiência Ovariana Prematura (IOP) é uma condição endocrinometabólica caracterizada pelo esgotamento prematuro da reserva folicular ovariana antes dos 40 anos, acometendo aproximadamente 1% das mulheres em idade reprodutiva. As inter…
View article: Buriti Oil (Mauritia flexuosa L.) as Functional Feed for Broiler Chickens
Buriti Oil (Mauritia flexuosa L.) as Functional Feed for Broiler Chickens Open
This experiment evaluated the effects of including buriti oil (BO) in the diet of broilers on growth performance, nutrient digestibility, carcass yield, meat quality, blood parameters, intestinal morphometry, the proliferation of collagen …
View article: A IMPORTÂNCIA DO POSICIONAMENTO FUNCIONAL PARA RECÉM NASCIDOS CRÍTICOS DURANTE O TRANSPORTE AEROMÉDICO
A IMPORTÂNCIA DO POSICIONAMENTO FUNCIONAL PARA RECÉM NASCIDOS CRÍTICOS DURANTE O TRANSPORTE AEROMÉDICO Open
View article: Potential Effects of Selected Synthetic Cannabinoids on Neuronal Senescence: Impact on Proliferation and Beta-Galactosidase Activity in SH-SY5Y Cells
Potential Effects of Selected Synthetic Cannabinoids on Neuronal Senescence: Impact on Proliferation and Beta-Galactosidase Activity in SH-SY5Y Cells Open
Introduction: Synthetic cannabinoids (SC) display a pharmacological mechanism similar to that of Δ9-tetrahydrocannabinol (THC), the key active principle of cannabis. SC are full agonists with higher potency at the CB1 and CB2 receptors, co…
View article: Uma proposta para o uso de RPG no Ensino de Física: A Vingança de Newton
Uma proposta para o uso de RPG no Ensino de Física: A Vingança de Newton Open
This work explores the use of Role Playing Games (RPG) as an active methodology in teaching Modern Physics, focusing on a game called Newton's Revenge. The game was developed with the aim of engaging students in collaborative and investiga…
View article: DESINFORMAÇÃO
DESINFORMAÇÃO Open
O tema se insere nos mecanismos de efetiva e substantiva proteção e defesa de direitos e garantias fundamentais. Aborda o debate sobre disciplina e controle, no âmbito jurídico, da disseminação de informações falsas sob a ótica de ameaça a…
View article: Vaccination in Adults with Diabetes Mellitus: A Position Statement of the Diabetes Mellitus Study Group of the Portuguese Society of Endocrinology, Diabetes, and Metabolism
Vaccination in Adults with Diabetes Mellitus: A Position Statement of the Diabetes Mellitus Study Group of the Portuguese Society of Endocrinology, Diabetes, and Metabolism Open
Diabetes mellitus (DM) is a very prevalent chronic disease worldwide, including in Portugal, and it is accompanied by significant morbidity and mortality. People with DM must follow the National Vaccination Program. Additionally, the Portu…
View article: Preimplantation genetic testing: A narrative review
Preimplantation genetic testing: A narrative review Open
Preimplantation genetic testing (PGT) is a diagnostic procedure that has become a powerful complement to assisted reproduction techniques. PGT has numerous indications, and there is a wide range of techniques that can be used, each with ad…
View article: The role of the adrenalectomy in the management of pheochromocytoma: the experience of a Portuguese referral center
The role of the adrenalectomy in the management of pheochromocytoma: the experience of a Portuguese referral center Open
View article: The role of Radiotherapy in relieving pain caused by calcaneal spur
The role of Radiotherapy in relieving pain caused by calcaneal spur Open
The pain caused by the calcaneal spur and the decreased quality of life are the hallmark features of this condition. Radiotherapy has been the subject of increasing evolution in recent decades for pain relief in both benign and malignant p…
View article: The role of the adrenalectomy in the management of pheochromocytoma: the experience of a Portuguese referral center
The role of the adrenalectomy in the management of pheochromocytoma: the experience of a Portuguese referral center Open
Purpose Pheochromocytoma is a rare neuroendocrine tumor. Despite the low incidence, these tumors are of indisputable importance. This study aimed to analyze the management of pheochromocytoma in a referral center, with an emphasis on the m…
View article: Genetic study on candidates for oocyte donation
Genetic study on candidates for oocyte donation Open
In conclusion, the genetic tests and the pre and post-test counseling is imperative to optimize reproductive outcomes in the oocyte donation process.
View article: Prevalência de patógenos respiratórios em rede de hospitais de São Paulo: análise do painel FilmArray (janeiro de 2023 a maio de 2024)
Prevalência de patógenos respiratórios em rede de hospitais de São Paulo: análise do painel FilmArray (janeiro de 2023 a maio de 2024) Open
Objetivo: As doenças respiratórias representam um desafio à saúde pública global, com alta morbimortalidade. O diagnóstico epidemiológico ágil e precoce é ferramenta fundamental para o tratamento mais assertivo e para a implementação de me…
View article: Peptide aggregation-induced immunogenic cell death in a breast cancer spheroid model
Peptide aggregation-induced immunogenic cell death in a breast cancer spheroid model Open
Utilizing multicellular aggregates (spheroids) for in vitro cancer research offers a physiologically relevant model that closely mirrors the intricate tumor microenvironment, capturing properties of solid tumors such as cell interactions a…
View article: Challenges in Perioperative Cerebral Oximetry Monitoring: A Case of Clofazimine-Induced Skin Pigmentation Interference
Challenges in Perioperative Cerebral Oximetry Monitoring: A Case of Clofazimine-Induced Skin Pigmentation Interference Open
View article: Gestão do conhecimento e gestão da inovação: análise comparativa de elementos correlacionados das normas ISO
Gestão do conhecimento e gestão da inovação: análise comparativa de elementos correlacionados das normas ISO Open
O conhecimento é considerado um importante ativo intangível das organizações contemporâneas, dada sua relevância em contribuir para a criação e sustentação de diferenciais competitivos. Além disso, o conhecimento também é um relevante recu…
View article: ESHRE PGT Consortium data collection XXI: PGT analyses in 2018
ESHRE PGT Consortium data collection XXI: PGT analyses in 2018 Open
STUDY QUESTION What are the trends and developments in preimplantation genetic testing (PGT) in 2018 as compared to previous years? SUMMARY ANSWER The main trends observed in this 21st dataset on PGT are that the implementation of trophect…
View article: Diverse monogenic subforms of human spermatogenic failure
Diverse monogenic subforms of human spermatogenic failure Open
View article: Contribution of TEX15 genetic variants to the risk of developing severe non-obstructive oligozoospermia
Contribution of TEX15 genetic variants to the risk of developing severe non-obstructive oligozoospermia Open
Background: Severe spermatogenic failure (SPGF) represents one of the most relevant causes of male infertility. This pathological condition can lead to extreme abnormalities in the seminal sperm count, such as severe oligozoospermia (SO) o…
View article: Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility
Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility Open
View article: Congenital Adrenal Hyperplasia – The Main Effect of 21-Hydroxylase Deficiency
Congenital Adrenal Hyperplasia – The Main Effect of 21-Hydroxylase Deficiency Open
Congenital adrenal hyperplasia (CAH) consists of a group of autosomal recessive disorders resulting from enzymatic defects in steroidogenesis. More than 95% of CAH cases result from a deficiency of the 21-hydroxylase enzyme, which leads to…
View article: Adrenal Glands - The Current Stage and New Perspectives of Diseases and Treatment
Adrenal Glands - The Current Stage and New Perspectives of Diseases and Treatment Open
The book presents an in-depth exploration of adrenal anatomy, physiology, and pathology, authored by a multidisciplinary team of international experts, providing an exposition of the current state of knowledge in the field of adrenal disea…
View article: Diverse Monogenic Subforms of Human Spermatogenic Failure
Diverse Monogenic Subforms of Human Spermatogenic Failure Open
Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically incurable with current medicine. Due to the biological complexity of sperm production, defining the genetic basis of NOA has proven challenging, an…
View article: Common genetic variation in <i>KATNAL1</i> non‐coding regions is involved in the susceptibility to severe phenotypes of male infertility
Common genetic variation in <i>KATNAL1</i> non‐coding regions is involved in the susceptibility to severe phenotypes of male infertility Open
Background Previous studies in animal models evidenced that genetic mutations of KATNAL1 , resulting in dysfunction of its encoded protein, lead to male infertility through disruption of microtubule remodelling and premature germ cell exfo…
View article: Common Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Sertoli Cell-Only Syndrome
Common Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Sertoli Cell-Only Syndrome Open
We aimed to analyze the role of the common genetic variants located in the PIN1 locus, a relevant prolyl isomerase required to control the proliferation of spermatogonial stem cells and the integrity of the blood–testis barrier, in the gen…
View article: Actionable secondary findings following exome sequencing of 836 non-obstructive azoospermia cases and their value in patient management
Actionable secondary findings following exome sequencing of 836 non-obstructive azoospermia cases and their value in patient management Open
STUDY QUESTION What is the load, distribution and added clinical value of secondary findings (SFs) identified in exome sequencing (ES) of patients with non-obstructive azoospermia (NOA)? SUMMARY ANSWER One in 28 NOA cases carried an identi…
View article: Differences in hormonal levels between heterozygous CYP21A2 pathogenic variant carriers, non-carriers, and females with non-classic congenital hyperplasia
Differences in hormonal levels between heterozygous CYP21A2 pathogenic variant carriers, non-carriers, and females with non-classic congenital hyperplasia Open
In this population of hyperandrogenic women and children, heterozygous carriers showed higher basal and stimulated 17OHP than non-carriers although normal basal and stimulated 17OHP responses do not exclude heterozygosity for CYP21A2