Explanipedia

Oftalmologia veterinária em foco: revisão das principais afecções cirúrgicas em cães e gatos Open

JAQUELINE APARECIDA SOUSA PEREIRA, Fátima Christina França Alexandrowitsch, VINICIUS JOSÉ MOREIRA NOGUEIR, Flávio Reis, Marina Garcia Eça , et al. · 2025

Intestinal mucosal alterations parallel central demyelination and remyelination: insights into the gut-brain axis in the cuprizone model of multiple sclerosis Open

Carolina Ferreira, Filipa S. Carvalho, Pedro M. Moraes‐Vieira, André de Castro Alves, Filipe Palavra , et al. · 2025

Background The gut-brain axis has been increasingly recognized as a critical factor in Multiple Sclerosis (MS) pathophysiology. While its role in demyelination is well documented, gut-brain axis involvement during remyelination remains lar…

EQUINE NEONATOLOGY: CLINICAL EVALUATION AND INTERVENTION STRATEGIES IN THE FIRST HOURS OF LIFE Open

Jaqueline Aparecida Sousa Pereira, Fátima Christina França Alexandrowitsch, Vinícius José Moreira Nogueira, Maria Clara Domingues da Silva, Vilmarie Rodriguez , et al. · 2025

Equine neonatology is a fundamental area of veterinary medicine, focused on the early diagnosis and clinical management of foals in the first hours of life, a period marked by heightened vulnerability and high mortality rates. This chapt…

Taxa de câmbio e preços no Brasil: uma revisão sistemática da literatura Open

Ludmilla R. C. Gonçalves, A. Quirino, Flávio Reis · 2025

Este artigo apresenta uma revisão sistemática dos estudos sobre a taxa de câmbio aplicados à economia brasileira, utilizando uma base de dados de 238 artigos indexados no JSTOR, Science Direct, Web Of Science e Scopus. O objetivo deste tra…

O USO DE PLANTAS MEDICINAIS E FITOTERÁPICOS NO CONTROLE GLICÊMICO DE PACIENTES COM DIABETES MELLITUS TIPO II: UMA REVISÃO DE LITERATURA Open

I. Costa Santos, M. Barros, Flávio Reis · 2025

Este artigo analisa os efeitos de plantas medicinais e fitoterápicos no controle glicêmico de pessoas com Diabetes Mellitus tipo II (DM2), por meio de uma revisão de literatura. A pesquisa abrangeu artigos publicados nas bases LILACS, PubM…

SPOROTRICHOSIS: AN EMERGING DISEASE FROM A UNIQUE HEALTH PERSPECTIVE Open

HOXANA XAVIER LOPES KATTAH, Jaqueline Aparecida Sousa Pereira, Diogo Couto, Fátima Christina França Alexandrowitsch, Flávio Reis , et al. · 2025

Sporotrichosis is a mycotic infection caused by a complex of fungal species of the genus Sporothrix. The domestic cat plays a crucial role in the transmission of the disease, being considered the main host and source of infection for human…

Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential Open

Rita Costa, Carolina Ferreira, André Luiz Moraes Alves, Sara Nunes, Flávio Reis , et al. · 2025

Background Lifestyle modifications, particularly the adoption of healthy dietary patterns such as the Mediterranean Diet (MedDiet), are foundational in any treatment plan, including for patients prescribed first-line statin therapy for hyp…

Digitization of Medical Device Displays Using Deep Learning Models: A Comparative Study Open

Pedro Carrilho Ferreira, Pedro Lobo, Flávio Reis, João L. Vilaça, Pedro Morais · 2025

With the growing number of patients living with chronic conditions, there is an increasing need for efficient systems that can automatically capture and convert medical device readings into digital data, particularly in home-based care set…

Nutrition and Gut Microbiota–Immune System Interplay in Chronic Diseases Open

Flávio Reis, Leonardo M. R. Ferreira, Eduardo Ortega, Sofia Viana · 2025

Non-communicable diseases, such as obesity, type 2 diabetes mellitus (T2DM), cardiovascular diseases, allergies, and cancer are escalating global health concerns [...]

Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency Open

Ricardo Lagoa, Rajan Logesh, Cristiana Violante, Smith B. Babiaka, Dorinda Marques‐da‐Silva , et al. · 2025

Curcumin, a natural compound found in turmeric, has shown promise in treating brain-related diseases and conditions associated with aging. Curcumin has shown multiple anti-inflammatory and brain-protective effects, but its clinical use is …

miRNA-642a-3p protects β cells from glucolipotoxicity Open

Sandra S. Pinhanços, Joana Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J. J. de Winter , et al. · 2025

The incidence of type 2 diabetes mellitus (T2DM) is tightly linked to obesity. High levels of circulating glucose and saturated free fatty acids (FFAs), known as glucolipotoxicity (GLT), is implicated in β cell dysfunction and/or death. Th…

The Use of Cystatin C as a Marker of Glomerular Filtration Rate in Clinical Practice Open

Flávio Reis, Elias David‐Neto · 2025

In the assessment of kidney function, it is widely acknowledged that the glomerular filtration rate (GFR) represents the most reliable indicator of kidney function. Ensuring precision and accuracy in the measurement (mGFR) or estimation of…

Gadoteric Acid and Gadolinium: Exploring Short- and Long-Term Effects on Healthy Animals Open

Susana Coimbra, Susana Rocha, Sofia Viana, Rute Rebelo, Petronila Rocha‐Pereira , et al. · 2025

Regarding the safety of gadolinium (Gd (III))-based contrast agents, we aimed to evaluate the short- and long-term effects following a single exposure to gadoteric acid (DOTA) or to free Gd (III) using animal models. Biomarkers of kidney i…

Two Cases of Prurigo Nodularis in Hematologic Malignancies: Hodgkin Lymphoma and Waldenström Macroglobulinemia Open

Flávio Reis, Francisca Sarmento, Sara Sarmento, Marta Freixa · 2025

Prurigo nodularis (PN) is a chronic inflammatory skin disorder marked by intense itching and firm, pruritic nodules, often linked to dermatologic, autoimmune, or systemic conditions, including malignancies such as hematologic cancers. We p…

USO DE PSICOTRÓPICOS EM UNIVERSITÁRIOS DA ÁREA DA SAÚDE Open

Flávio Reis, Guilherme Ataide Novaes, Isabela Pereira Medeiros, Claudia Danyella Alves Leão Ribeiro · 2024

Este estudo objetivou avaliar a prevalência do uso de psicotrópicos por universitários da área da saúde. Trata-se de um estudo epidemiológico, transversal e quantitativo. A pesquisa foi realizada em um Centro Universitário, situado na cida…

MODELO TEÓRICO PARA PROTOTIPAÇÃO DE TECNOLOGIA ASSISTIVA E AUTOMAÇÃO DOMÉSTICA COM ARDUÍNO Open

Flávio Reis, Natália Fernandes da Motta, Arthur Alves Costa Lignani de Miranda, Ercília de Stefano, Tatiana Tavares Rodriguez , et al. · 2024

O objetivo geral deste estudo foi a proposição de um modelo teórico que integra componentes acessíveis de robótica e software para criar um sistema de baixo custo, levando em consideração tanto a identificação de critérios sobre automação …

CINCO NOVAS PISTAS SOBRE COMO A TECNOLOGIA V2I PODE CONTRIBUIR PARA O PLANEJAMENTO E GERENCIAMENTO DA MOBILIDADE URBANA Open

Natália Fernandes da Motta, Flávio Reis, Arthur Alves Costa Lignani de Miranda, Ercília de Stefano, Cristiano Gomes Casagrande , et al. · 2024

Em síntese os sistemas V2I podem otimizar o fluxo de tráfego ao fornecer informações em tempo real para veículos, permitindo ajustes automáticos de velocidade e rotas. Nesse sentido, como a união entre sistema de inteligência de transporte…

DEFINIÇÃO DE CRITÉRIOS E CARACTERIZAÇÃO DAS ALTERNATIVAS DO MODELO TEÓRICO PARA SUBSIDIAR O AHP GREEN MOVING CAR (GMC) Open

Natália Fernandes da Motta, Flávio Reis, Arthur Alves Costa Lignani de Miranda, Ercília de Stefano, Aline Silva Ferreira · 2024

O planejamento urbano exige resultados em termos de mobilidade sustentável. Para ser sustentável, este planejamento demanda ampla participação dos diversos atores e organizações, contudo a população leiga nem sempre aparenta ter conhecimen…

DEFINIÇÃO DE CRITÉRIOS E CARACTERIZAÇÃO DAS ALTERNATIVAS DO MODELO TEÓRICO PARA SUBSIDIAR O AHP GREEN MOVING CAR (GMC) Open

Natália Fernandes da Motta, Flávio Reis, Ana Luísa P. Miranda, Ercília de Stefano, Aline Silva Ferreira · 2024

O planejamento urbano exige resultados em termos de mobilidade sustentável. Para ser sustentável, este planejamento demanda ampla participação dos diversos atores e organizações, contudo a população leiga nem sempre aparenta ter conhecimen…

MODELO TEÓRICO PARA PROTOTIPAÇÃO DE TECNOLOGIA ASSISTIVA E AUTOMAÇÃO DOMÉSTICA COM ARDUÍNO Open

Flávio Reis, Natália Fernandes da Motta, Arthur Alves Costa Lignani de Miranda, Ercília de Stefano, Tatiana Tavares Rodriguez , et al. · 2024

O objetivo geral deste estudo foi a proposição de um modelo teórico que integra componentes acessíveis de robótica e software para criar um sistema de baixo custo, levando em consideração tanto a identificação de critérios sobre automação …

Cidades-esponjas: lições da literatura científica para a prática da sustentabilidade nos desafios do ambiente construído Open

Arthur Alves Costa Lignani de Miranda, Flávio Reis, Natália Fernandes da Motta, Tatiana Tavares Rodriguez, Marcos Martins Borges , et al. · 2024

Na atualidade as cidades nomeadas de esponjas são objetos do estudo da interface entre ambientes construídos e sustentabilidade, considerando-se as relações entre tais fatores. Diante da demanda por soluções urbanas mais sustentáveis, o co…

The senotherapeutic potential of phytochemicals for age-related intestinal disease Open

C Costa, Sílvia Santos Pedrosa, James L. Kirkland, Flávio Reis, Ana Raquel Madureira · 2024

During the last few decades, life expectancy has increased worldwide along with the prevalence of several age-related diseases. Among aging pathways, cellular senescence and chronic inflammation (or "inflammaging") appear to be connected t…

Much More Than a Stroke: Emery-Dreifuss Muscular Dystrophy Type 2 Revealed by Ischemic Stroke Open

Francisco Rocha‐Gonçalves, Daniela Duarte, Flávio Reis, Alexandra Vaz, Ana Gomes · 2024

Emery-Dreifuss muscular dystrophy type 2 (EDMD2) is a rare autosomal dominant neuromuscular disorder caused by LMNA gene mutations and characterized by progressive skeletal muscle weakness and significant cardiac involvement. We report the…

Stay Away From the Cold: An Unusual Case of Cold Agglutinin Disease Presenting as Recurrent Transient Ischemic Attacks Open

Francisco Rocha‐Gonçalves, Daniela Duarte, Flávio Reis, Alexandra Vaz, Ana Gomes · 2024

Exploring quercetin's protective potential against the pro-inflammatory effects of silver nanoparticles in C57BL/6J mice Open

Adelaide Sousa, Andreia Amaro, Vera Marisa Costa, Rui Azevedo, Sara Oliveira , et al. · 2024

The increasing prevalence of silver nanoparticles (AgNP) in various applications has sparked concerns about their potential adverse effects on human health. Hence, it is crucial to devise strategies to minimize their detrimental effects. Q…

Exploring yeast glucans for vaccine enhancement: Sustainable strategies for overcoming adjuvant challenges in a SARS-CoV-2 model Open

João Azevedo‐Silva, Manuela Amorim, Diana Tavares‐Valente, Pedro Sousa, Raodoh Mohamath , et al. · 2024

Vaccine adjuvants are important for enhancing vaccine efficacy, and although aluminium salts (Alum) are the most used, their limited ability to induce specific immune responses has spurred the search for new adjuvants. However, many adjuva…

#1502 Short-term effects of gadolinium and gadoteric acid on kidney — impact on inflammation Open

Susana Coimbra, Susana Rocha, Sofia Viana, Rute Rebelo, Maria João Valente , et al. · 2024

Background and Aims The nephrotoxicity of free gadolinium [Gd (III)] has been reported, raising concerns about the safety of gadolinium-based contrast agents (GBCA), widely used in magnetic resonance imaging. The GBCA with macrocyclic stru…

#1613 Gadolinium and gadoteric acid's short-term impact on kidney function and lipid profile Open

Luı́s Belo, Susana Coimbra, Susana Rocha, Sofia Viana, Rute Rebelo , et al. · 2024

Background and Aims Concerns regarding the safety of gadolinium-based contrast agents (GBCA), which are often employed in medical imaging, have been raised in light of reports of free gadolinium's [Gd (III)] cytotoxicity. It appears that G…

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases Open

Carolina Ferreira, Pedro Vieira, Susana Machado, João O. Malva, Miguel Castelo‐Branco , et al. · 2024

Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune and non-autoimmune mediated. The immune system regulates the functioning …

Molecular Pharmacology in Diabetes Open

Flávio Reis, Rosa Fernandes · 2024

This Special Issue highlights the key molecules and molecular signaling pathways associated with diabetes and its multifaceted complications [...]

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