Filippo Alongi
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View article: Clinical Feasibility and Safety of 1.5 T MR-Guided Daily Adapted Radiotherapy in 1000 Patients: A Real-World Large Experience of an Early-Adopter Center
Clinical Feasibility and Safety of 1.5 T MR-Guided Daily Adapted Radiotherapy in 1000 Patients: A Real-World Large Experience of an Early-Adopter Center Open
View article: Oligometastatic Mesothelioma Treated with Ablative Radiotherapy (OMAR): A Multicenter Study
Oligometastatic Mesothelioma Treated with Ablative Radiotherapy (OMAR): A Multicenter Study Open
Background/Objectives: This multicenter retrospective study aims to evaluate the role of Ablative Radiotherapy (RT) in patients with unresectable pleural mesothelioma (PM) who experienced radiological progression after at least one line of…
View article: Penalized-Survival Nomogram Predicts 5-Year Metastasis-Free Survival After Salvage Radiotherapy for Postprostatectomy Patients: A Multicenter Study
Penalized-Survival Nomogram Predicts 5-Year Metastasis-Free Survival After Salvage Radiotherapy for Postprostatectomy Patients: A Multicenter Study Open
This externally validated nomogram provides a practical tool for predicting 5-year DMFS in patients undergoing SRT. It enables personalized risk assessment, guiding intensified surveillance and treatment for high-risk patients.
View article: The Clinical Feasibility and Safety of 1.5 T MR-Guided Daily Adapted Radiotherapy in 1000 Patients: A Real-World Large Experience of an Early-Adopter Center
The Clinical Feasibility and Safety of 1.5 T MR-Guided Daily Adapted Radiotherapy in 1000 Patients: A Real-World Large Experience of an Early-Adopter Center Open
Purpose/Objective: The clinical implementation of MR-guided radiotherapy on MR-linacs (MRL) hasrapidly increased in recent years. The advantages represented by the MR-based daily online plan adaptation and real-time monitoring have been ex…
View article: Impact of Metastasis-directed Therapy Guided by Different PET/CT Radiotracers on Distant and Local Disease Control in Oligorecurrent Hormone-sensitive Prostate Cancer: A Secondary Analysis of the PRECISE-MDT Study
Impact of Metastasis-directed Therapy Guided by Different PET/CT Radiotracers on Distant and Local Disease Control in Oligorecurrent Hormone-sensitive Prostate Cancer: A Secondary Analysis of the PRECISE-MDT Study Open
Metastasis-directed therapy guided by gallium 68 ( 68 Ga) prostate-specific membrane antigen (PSMA)-11 PET/CT improved metastasis-free survival but not local recurrence-free survival compared with fluorine 18 ( 18 F)-PSMA-1007 and 18 F-flu…
View article: Prostate Cancer Diagnosis and Treatment in Elderly Patients: A Cross-Sectional Survey Exploring Practice Patterns and Preferences of Uro-Oncologists in Northeast Italy
Prostate Cancer Diagnosis and Treatment in Elderly Patients: A Cross-Sectional Survey Exploring Practice Patterns and Preferences of Uro-Oncologists in Northeast Italy Open
Background: The optimal diagnostic and therapeutic strategies for prostate cancer (PCa) in patients aged ≥75 years (mild-old and oldest-old) are still contentious. Resource allocation and ideal treatment for older patients are challenges, …
View article: Salvage Radiotherapy Following Nonradiotherapy Ablative Techniques for Primary Prostate Cancer: A Systematic Review and Meta-analysis
Salvage Radiotherapy Following Nonradiotherapy Ablative Techniques for Primary Prostate Cancer: A Systematic Review and Meta-analysis Open
View article: MR‐Linac is a better choice for adaptive therapy compared to cone‐beam CT
MR‐Linac is a better choice for adaptive therapy compared to cone‐beam CT Open
View article: The expanding role of next-generation imaging in prostate cancer management: a cross-sectional survey exploring the clinical practice of uro-oncologists in North-Eastern Italy; on behalf of GUONE (Gruppo Uro-Oncologico del Nord-Est)
The expanding role of next-generation imaging in prostate cancer management: a cross-sectional survey exploring the clinical practice of uro-oncologists in North-Eastern Italy; on behalf of GUONE (Gruppo Uro-Oncologico del Nord-Est) Open
Background: Next-generation imaging (NGI) technologies such as multiparametric magnetic resonance imaging (mpMRI) and total-body NGI (tbNGI) methodologies including choline, fluciclovine or PSMA positron emission tomography/computed tomogr…
View article: MR-Guided Adaptive Radiotherapy in Localized Prostate Cancer
MR-Guided Adaptive Radiotherapy in Localized Prostate Cancer Open
MR-guided radiotherapy (MRgRT) is novel treatment modality in Radiation Oncology that could allow a higher precision and tolerability of Radiation Treatments. This modality is possible due to dedicated systems consisting of a MR scanner mo…
View article: Analysis of Patients with Locally Advanced Rectal Cancer Given Neoadjuvant Radiochemotherapy with or Without Rt Dose Intensification: A Multicenter Retrospective Study – Atlantis Part Ii
Analysis of Patients with Locally Advanced Rectal Cancer Given Neoadjuvant Radiochemotherapy with or Without Rt Dose Intensification: A Multicenter Retrospective Study – Atlantis Part Ii Open
View article: Urethra-sparing prostate cancer radiotherapy: Current practices and future insights from an international survey
Urethra-sparing prostate cancer radiotherapy: Current practices and future insights from an international survey Open
Urethra-sparing is a promising technique for the mitigation of urinary toxicity in prostate cancer patients undergoing EBRT, particularly recommended for ultra-hypofractionation and reirradiation with SBRT. The lack of consensus on specifi…
View article: TEMPORARY REMOVAL: ESTRO/EANO recommendation on reirradiation of glioblastoma
TEMPORARY REMOVAL: ESTRO/EANO recommendation on reirradiation of glioblastoma Open
View article: P056 First clinical application of comprehensive motion management with 1.5T MR-linac on prostate cancer patients treated with radiotherapy: Technical issues and suggested workflow
P056 First clinical application of comprehensive motion management with 1.5T MR-linac on prostate cancer patients treated with radiotherapy: Technical issues and suggested workflow Open
View article: The emerging role of Artificial Intelligence in proton therapy: A review
The emerging role of Artificial Intelligence in proton therapy: A review Open
View article: Reply to: Comment on “Repeated HyperArc radiosurgery for recurrent intracranial metastases and dosimetric analysis of recurrence pattern to account for diffuse dose effect on microscopical disease”
Reply to: Comment on “Repeated HyperArc radiosurgery for recurrent intracranial metastases and dosimetric analysis of recurrence pattern to account for diffuse dose effect on microscopical disease” Open
The interesting letter from Di Perri permit us to discuss more extensively the findings of our study and future clinical application of brain RT [1Nicosia L. Allegra A.G. Giaj-Levra N. Bayani R. Darzikolaee N.M. Mazzola R. et al.Repeated H…
View article: Repeated HyperArc radiosurgery for recurrent intracranial metastases and dosimetric analysis of recurrence pattern to account for diffuse dose effect on microscopical disease
Repeated HyperArc radiosurgery for recurrent intracranial metastases and dosimetric analysis of recurrence pattern to account for diffuse dose effect on microscopical disease Open
Intracranical relapses can be safely and effectively treated with repeated HyperArc, with the aim to postpone or avoid WBRT. Diffuse dose by volumetric RT might reduce microscopic disease also at relatively low levels, potentially acting a…
View article: Diverse Imaging Methods May Influence Long-Term Oncologic Outcomes in Oligorecurrent Prostate Cancer Patients Treated with Metastasis-Directed Therapy (the PRECISE-MDT Study)
Diverse Imaging Methods May Influence Long-Term Oncologic Outcomes in Oligorecurrent Prostate Cancer Patients Treated with Metastasis-Directed Therapy (the PRECISE-MDT Study) Open
Metastasis-directed therapy (MDT) has been tested in clinical trials as a treatment option for oligorecurrent prostate cancer (PCa). However, there is an ongoing debate regarding the impact of using different imaging techniques interchange…
View article: Patient-Reported Outcomes Following Magnetic Resonance-Guided Radiation Therapy for Prostate Cancer: A Systematic Review and Meta-Analysis
Patient-Reported Outcomes Following Magnetic Resonance-Guided Radiation Therapy for Prostate Cancer: A Systematic Review and Meta-Analysis Open
MRgRT for PC results in a temporary worsening of patient-reported urinary and bowel symptoms during the first month after treatment compared with pre-RT, resolving at 3 months. No clinically relevant changes were found for general quality …
View article: SBRT in Lymph-Nodal Oligometastases from Prostate Cancer: Different Outcomes between Pelvic and Para-Aortic Disease
SBRT in Lymph-Nodal Oligometastases from Prostate Cancer: Different Outcomes between Pelvic and Para-Aortic Disease Open
Background: Lymph-nodal prostate cancer oligometastases are differently treated according to their site: pelvic are locoregional lymph nodes; instead, para-aortic lymph nodes are considered as distant metastases. The aim of the study was a…
View article: Feasibility and Acute Toxicity of Hypo-Fractionated Radiotherapy on 0.35T MR-LINAC: The First Prospective Study in Spain
Feasibility and Acute Toxicity of Hypo-Fractionated Radiotherapy on 0.35T MR-LINAC: The First Prospective Study in Spain Open
This observational, descriptive, longitudinal, and prospective basket-type study (Registry #5289) prospectively evaluated the feasibility and acute toxicity of hypo-fractionated radiotherapy on the first 0.35T MR-LINAC in Spain. A total of…
View article: Cancer-specific dose and fractionation schedules in stereotactic body radiotherapy for oligometastatic disease: An interim analysis of the EORTC-ESTRO E2-RADIatE OligoCare study
Cancer-specific dose and fractionation schedules in stereotactic body radiotherapy for oligometastatic disease: An interim analysis of the EORTC-ESTRO E2-RADIatE OligoCare study Open
This real-world analysis suggests that SBRT doses are adjusted to the primary cancers and oligometastasis location. Future analysis will address safety and efficacy of this site- and disease-adapted SBRT fractionation approach (NCT03818503…
View article: Lymph-Nodal Oligometastases from Prostate Cancer: Different Outcomes and Pattern of Relapse between Pelvic and Para-Aortic Disease
Lymph-Nodal Oligometastases from Prostate Cancer: Different Outcomes and Pattern of Relapse between Pelvic and Para-Aortic Disease Open
Introduction: Lymph-nodal prostate cancer oligometastases are differently treated according to their site: pelvic are locoregional lymph-nodes, instead para-aortic lymph-nodes are considered as distant metastases. Aim of the study was a co…
View article: ONE SHOT - single shot radiotherapy for localized prostate cancer: 18-month results of a single arm, multicenter phase I/II trial
ONE SHOT - single shot radiotherapy for localized prostate cancer: 18-month results of a single arm, multicenter phase I/II trial Open
In this multicenter phase I/II trial, we demonstrated that a 19 Gy single-fraction urethra-sparing SBRT is feasible and associated with an acceptable toxicity rate, mostly returning to the baseline at week-12 and with a symptoms flare betw…
View article: Radiotherapy of Oligometastatic Cancers
Radiotherapy of Oligometastatic Cancers Open
The enhanced multidisciplinary treatment approach and the widespread use of advanced imaging techniques have led to an improvement in survival rates, inevitably associated with an increase in the number of oligometastatic diagnoses in canc…
View article: MR-LINAC, a New Partner in Radiation Oncology: Current Landscape
MR-LINAC, a New Partner in Radiation Oncology: Current Landscape Open
Technological advances in radiation oncology are oriented towards improving treatment precision and tumor control. Among these advances, magnetic-resonance-image-guided radiation therapy (MRgRT) stands out, with technological advances to d…
View article: Analysis of Patients with Locally Advanced Rectal Cancer Given Neoadjuvant Radiochemotherapy with or Without Rt Dose Intensification: A Multicenter Retrospective Study – Atlantis Part I
Analysis of Patients with Locally Advanced Rectal Cancer Given Neoadjuvant Radiochemotherapy with or Without Rt Dose Intensification: A Multicenter Retrospective Study – Atlantis Part I Open
View article: Health-related quality of life in men with oligometastatic prostate cancer following metastases-directed stereotactic body radiotherapy: Real-world data from the E2-RADIatE OligoCare cohort
Health-related quality of life in men with oligometastatic prostate cancer following metastases-directed stereotactic body radiotherapy: Real-world data from the E2-RADIatE OligoCare cohort Open
View article: “Things Have Changed”—Laparoscopic Cytoreduction for Advanced and Recurrent Ovarian Cancer: The Experience of a Referral Center on 108 Patients
“Things Have Changed”—Laparoscopic Cytoreduction for Advanced and Recurrent Ovarian Cancer: The Experience of a Referral Center on 108 Patients Open
Objective: To report the feasibility of laparoscopic cytoreduction surgery for primary and recurrent ovarian cancer in a select group of patients. Methods: A retrospective analysis was conducted on a cohort of patients with FIGO stage IIIA…
View article: The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview
The state‐of‐the‐art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview Open
Introduction Cardiac arrhythmias, including ventricular tachycardia (VT), stand as a significant threat to health, often leading to mortality and sudden cardiac death. While conventional treatments for VT exhibit efficacy, cases of refract…