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View article: Fluid responsiveness
Fluid responsiveness Open
View article: Modulation of the Renin–Angiotensin System in Critically Ill Patients: Addressing Seven Key Questions for the Intensivist
Modulation of the Renin–Angiotensin System in Critically Ill Patients: Addressing Seven Key Questions for the Intensivist Open
View article: Features, Outcome, and Treatment of Postanoxic Status Epilepticus
Features, Outcome, and Treatment of Postanoxic Status Epilepticus Open
View article: All MOVPE Grown Quadruple Junction InGaP/InGaAs/Ge/Ge Solar Cell
All MOVPE Grown Quadruple Junction InGaP/InGaAs/Ge/Ge Solar Cell Open
Most commercially available InGaP/InGaAs/Ge triple-junction solar cells suffer from current mismatch due to the excess current generated by the Ge sub-cell. Combining epitaxial germanium with III–V materials would enable the realization of…
View article: Dobutamine administration: a proposal for a standardized approach
Dobutamine administration: a proposal for a standardized approach Open
View article: Features, Outcome, and Treatment of Postanoxic Status Epilepticus
Features, Outcome, and Treatment of Postanoxic Status Epilepticus Open
Patients with postanoxic definite or possible SE have a 25% chance of good outcome in the absence of ≥2 poor outcome ERC/ESICM factors. EEG background continuity before SE onset and higher discharge frequency contribute to the identificati…
View article: Correction: MACCHINI et al. Intra-Arrest Therapeutic Hypothermia and Neurologic Outcome in Patients Admitted After Out-of-Hospital Cardiac Arrest: A Post Hoc Analysis of the Princess Trial. Brain Sci. 2022, 12, 1374
Correction: MACCHINI et al. Intra-Arrest Therapeutic Hypothermia and Neurologic Outcome in Patients Admitted After Out-of-Hospital Cardiac Arrest: A Post Hoc Analysis of the Princess Trial. Brain Sci. 2022, 12, 1374 Open
In the original publication [...]
View article: A Restrictive Versus a Liberal Transfusion Strategy in Patients With Spontaneous Intracerebral Hemorrhage: A Secondary Analysis of TRAIN Randomized Clinical Trial
A Restrictive Versus a Liberal Transfusion Strategy in Patients With Spontaneous Intracerebral Hemorrhage: A Secondary Analysis of TRAIN Randomized Clinical Trial Open
BACKGROUND: Red blood cell transfusions are commonly administered to anemic patients with spontaneous intracerebral hemorrhage (ICH); however, the optimal hemoglobin threshold to initiate transfusion is uncertain in this population. Theref…
View article: Ivabradine use in critical care: a systematic review and metanalysis of cardiogenic and septic shock patients
Ivabradine use in critical care: a systematic review and metanalysis of cardiogenic and septic shock patients Open
View article: Risk, rate or rhythm control for new onset supraventricular arrhythmia during septic shock: protocol for the CAFS multicentre, parallel-group, open-label trial
Risk, rate or rhythm control for new onset supraventricular arrhythmia during septic shock: protocol for the CAFS multicentre, parallel-group, open-label trial Open
Introduction New-onset supraventricular arrhythmia (NOSVA) is the most common arrhythmia in patients with septic shock and is associated with haemodynamic alterations and increased mortality rates. With no data available from randomised tr…
View article: Intravascular vs. surface cooling in out-of-hospital cardiac arrest patients receiving hypothermia after hospital arrival: a post hoc analysis of the TTM2 trial
Intravascular vs. surface cooling in out-of-hospital cardiac arrest patients receiving hypothermia after hospital arrival: a post hoc analysis of the TTM2 trial Open
Among OHCA patients randomized to hypothermia in the TTM2 study, intravascular cooling, compared with surface cooling, was associated with better cooling performance.
View article: Alterations in the renin-angiotensin system during septic shock
Alterations in the renin-angiotensin system during septic shock Open
View article: Liberal versus restrictive transfusion strategies in subarachnoid hemorrhage: a secondary analysis of the TRAIN study
Liberal versus restrictive transfusion strategies in subarachnoid hemorrhage: a secondary analysis of the TRAIN study Open
ClinicalTrials.gov number-NCT02968654 registered on November 16th, 2016.
View article: Posttranslational histone 3 modification patterns in experimental septic and cardiogenic shock
Posttranslational histone 3 modification patterns in experimental septic and cardiogenic shock Open
Background: Histones are released during cellular damage and cell death. In addition to their intrinsic toxicity, posttranslational modifications (PTMs) in histones impact the sepsis response. Histone PTMs in cardiogenic shock (CS) remain …
View article: Vasopressor Therapy
Vasopressor Therapy Open
Vasopressor therapy represents a key part of intensive care patient management, used to increase and maintain vascular tone and thus adequate tissue perfusion in patients with shock. Norepinephrine is the preferred first-line agent because…
View article: The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II
The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II Open
Dysregulation of the renin–angiotensin–aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and in…
View article: Alteplase in COVID-19 severe hypoxemic respiratory failure: the TRISTARDS multicenter randomized trial
Alteplase in COVID-19 severe hypoxemic respiratory failure: the TRISTARDS multicenter randomized trial Open
View article: Oxygen extraction–guided transfusion strategy in critically ill patients: study protocol for a randomised, open-labelled, controlled trial
Oxygen extraction–guided transfusion strategy in critically ill patients: study protocol for a randomised, open-labelled, controlled trial Open
Introduction In critically ill patients, individualised strategies for red blood cell transfusion (RBCT) are lacking. The objective of this study is to demonstrate the potential advantages of employing an individualised transfusion strateg…
View article: Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study
Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study Open
View article: Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury Open
Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 …
View article: Alterations in the Renin-Angiotensin System in Experimental Septic Shock
Alterations in the Renin-Angiotensin System in Experimental Septic Shock Open
OBJECTIVES: To analyze dynamic changes in the renin-angiotensin system (RAS) during septic shock, focusing on angiotensin-converting enzyme (ACE) activity and the balance between angiotensin peptides, using a mass spectrometry method. DESI…
View article: Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest
Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest Open
In this experimental model, SBHB infusion after resuscitated CA was associated with reduced circulating markers of cerebral injury and increased sEEG amplitude.
View article: Extracorporeal cardiopulmonary resuscitation: a comparison of two experimental approaches and systematic review of experimental models
Extracorporeal cardiopulmonary resuscitation: a comparison of two experimental approaches and systematic review of experimental models Open
View article: Angiotensin-(1–7) infusion in COVID-19 patients admitted to the ICU: a seamless phase 1–2 randomized clinical trial
Angiotensin-(1–7) infusion in COVID-19 patients admitted to the ICU: a seamless phase 1–2 randomized clinical trial Open
View article: Circulating Nucleosomes as a Novel Biomarker for Sepsis: A Scoping Review
Circulating Nucleosomes as a Novel Biomarker for Sepsis: A Scoping Review Open
Circulating nucleosome levels are commonly elevated in physiological and pathological conditions. Their potential as biomarkers for diagnosing and prognosticating sepsis remains uncertain due, in part, to technical limitations in existing …
View article: Inhibition of circulating dipeptidyl-peptidase 3 by procizumab in experimental septic shock reduces catecholamine exposure and myocardial injury
Inhibition of circulating dipeptidyl-peptidase 3 by procizumab in experimental septic shock reduces catecholamine exposure and myocardial injury Open
View article: Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use
Ketone Bodies after Cardiac Arrest: A Narrative Review and the Rationale for Use Open
Cardiac arrest survivors suffer the repercussions of anoxic brain injury, a critical factor influencing long-term prognosis. This injury is characterised by profound and enduring metabolic impairment. Ketone bodies, an alternative energeti…
View article: Ivabradine in Septic Shock: A Narrative Review
Ivabradine in Septic Shock: A Narrative Review Open
In patients with septic shock, compensatory tachycardia initially serves to maintain adequate cardiac output and tissue oxygenation but may persist despite appropriate fluid and vasopressor resuscitation. This sustained elevation in heart …
View article: A Comparison of Prognostic Factors in a Large Cohort of In-Hospital and Out-of-Hospital Cardiac Arrest Patients
A Comparison of Prognostic Factors in a Large Cohort of In-Hospital and Out-of-Hospital Cardiac Arrest Patients Open
We investigated independent factors predicting neurological outcome and death, comparing in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA) patients. The study was conducted in the mixed 34-bed Intensive Care Department at the Hô…
View article: The design of the PRINCESS 2 trial: A randomized trial to study the impact of ultrafast hypothermia on complete neurologic recovery after out-of-hospital cardiac arrest with initial shockable rhythm
The design of the PRINCESS 2 trial: A randomized trial to study the impact of ultrafast hypothermia on complete neurologic recovery after out-of-hospital cardiac arrest with initial shockable rhythm Open