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View article: The International, Prospective COSMOS (CytOSorb ® TreatMent Of Critically Ill PatientS) Registry: Results from the first 300 patients
The International, Prospective COSMOS (CytOSorb ® TreatMent Of Critically Ill PatientS) Registry: Results from the first 300 patients Open
IntroductionBlood purification techniques are being investigated as adjunctive options in critically ill patients not only to treat severe inflammation but also to remove harmful substances such as myoglobin in rhabdomyolysis. Yet, the ava…
View article: Isolated C3 hypocomplementemia as an early predictor of chronic kidney disease in lupus nephritis
Isolated C3 hypocomplementemia as an early predictor of chronic kidney disease in lupus nephritis Open
Objective The role of complement in the long-term renal survival of patients with lupus nephritis (LN) remains poorly understood. Recent studies suggest its potential impact; however, long-term data are lacking. Methods This multicenter, o…
View article: Exercise therapy to improve mobility, active behaviour and quality of life of chronic kidney disease patients with peripheral artery disease: study protocol for the EXACT-CKDPAD multicentre randomised controlled trial
Exercise therapy to improve mobility, active behaviour and quality of life of chronic kidney disease patients with peripheral artery disease: study protocol for the EXACT-CKDPAD multicentre randomised controlled trial Open
The combination of chronic kidney disease (CKD) and peripheral artery disease (PAD) enhances the already present high cardiovascular risk, exposing the affected patients to unfavourable long-term clinical outcomes. Physical exercise is con…
View article: The international, prospective CytOSorbⓇ treatMent Of critically ill patientS (COSMOS) registry: Interim results from the first 150 patients
The international, prospective CytOSorbⓇ treatMent Of critically ill patientS (COSMOS) registry: Interim results from the first 150 patients Open
The COSMOS registry highlights CS-associated improvements in lactate, creatinine, norepinephrine needs, fluid balance, and oxygenation. Mortality was favorable compared with risk-based predictions.Trial registration Clinicaltrials.gov Iden…
View article: CKD-associated pruritus in haemodialysis: a road map for diagnosis and treatment
CKD-associated pruritus in haemodialysis: a road map for diagnosis and treatment Open
Of the wide range of symptoms affecting patients with chronic kidney disease (CKD) on haemodialysis, CKD-associated pruritus is one of the most common and burdensome, occurring at moderate-to-severe intensity in 31%–40% of patients, signif…
View article: Rethinking caution: a critical appraisal of extracorporeal blood purification in sepsis
Rethinking caution: a critical appraisal of extracorporeal blood purification in sepsis Open
View article: Difelikefalin for CKD-aP: real world evidence of efficacy and safety in Italian patients
Difelikefalin for CKD-aP: real world evidence of efficacy and safety in Italian patients Open
Background Chronic kidney disease–associated pruritus (CKD-aP), defined as moderate to severe itching directly related to kidney disease, affects about one-third of haemodialysis patients and has been associated with poor quality of life, …
View article: A roundish dark spot in the upper cava vein
A roundish dark spot in the upper cava vein Open
View article: Use of extracorporeal blood purification therapies in sepsis: the current paradigm, available evidence, and future perspectives
Use of extracorporeal blood purification therapies in sepsis: the current paradigm, available evidence, and future perspectives Open
View article: The Global Kidney Patient Trials Network and the CAPTIVATE Platform Clinical Trial Design
The Global Kidney Patient Trials Network and the CAPTIVATE Platform Clinical Trial Design Open
Importance Chronic kidney disease (CKD) is a global health priority affecting almost 1 billion people. New therapeutic options and clinical trial innovations such as adaptive platform trials provide an opportunity to efficiently test combi…
View article: Efficacy and safety of dapagliflozin in patients with CKD: real-world experience in 93 Italian renal clinics
Efficacy and safety of dapagliflozin in patients with CKD: real-world experience in 93 Italian renal clinics Open
Background Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are recommended for reducing the renal and cardiovascular risk in patients with chronic kidney disease (CKD) based on the positive results reported by clinical trials. However,…
View article: Multiple Renal Infarctions in Spontaneous Double Renal Artery Dissection: A Case Report
Multiple Renal Infarctions in Spontaneous Double Renal Artery Dissection: A Case Report Open
Background: As spontaneous renal artery dissection (SRAD) is a rare cause of abdominal pain, bilateral dissection is an extremely rare event. Only approximately two hundred cases of SRAD have been reported in the literature. The diagnosis …
View article: Changes in 24-hour blood pressure profile after 12 weeks of dapagliflozin treatment in patients with diabetic kidney disease: an Italian multicenter prospective study
Changes in 24-hour blood pressure profile after 12 weeks of dapagliflozin treatment in patients with diabetic kidney disease: an Italian multicenter prospective study Open
Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) lower ambulatory blood pressure (ABP) in patients with type 2 diabetes mellitus; whether the same holds true in diabetic kidney disease (DKD) is unknown. This information is cri…
View article: Physical activity and exercise in chronic kidney disease: consensus statements from the Physical Exercise Working Group of the Italian Society of Nephrology
Physical activity and exercise in chronic kidney disease: consensus statements from the Physical Exercise Working Group of the Italian Society of Nephrology Open
View article: How histopathological diagnosis interacts with kidney ultrasound parameters and glomerular filtration rate
How histopathological diagnosis interacts with kidney ultrasound parameters and glomerular filtration rate Open
View article: Does Physical Exercise Ameliorate Chronic Kidney Disease-Related Complications? The Case of Anaemia and Chronic Kidney Disease-Mineral Bone Disorder
Does Physical Exercise Ameliorate Chronic Kidney Disease-Related Complications? The Case of Anaemia and Chronic Kidney Disease-Mineral Bone Disorder Open
Background: Physical exercise (PE) can regulate inflammation, cardiovascular health, sarcopenia, anaemia, and bone health in the chronic kidney disease (CKD) population. Experimental and clinical studies both help us better understand the …
View article: Prevalence, risk factors, and treatment of anemia in hospitalized older patients across geriatric and nephrological settings in Italy
Prevalence, risk factors, and treatment of anemia in hospitalized older patients across geriatric and nephrological settings in Italy Open
Anemia is a common but often underdiagnosed and undertreated geriatric syndrome in hospitalized older patients. In this retrospective multicenter study, we aimed at characterizing the prevalence, risk factors, diagnostic and treatment appr…
View article: Hemoadsorption therapy for myoglobin removal in rhabdomyolysis: consensus of the hemoadsorption in rhabdomyolysis task force
Hemoadsorption therapy for myoglobin removal in rhabdomyolysis: consensus of the hemoadsorption in rhabdomyolysis task force Open
View article: How Do Physical Activity and Exercise Affect Fabry Disease? Exploring a New Opportunity
How Do Physical Activity and Exercise Affect Fabry Disease? Exploring a New Opportunity Open
Background: Fabry disease (FD) is a multisystem, monogenic, X-linked storage disorder caused by mutations in the GLA gene, resulting in reduced alfa-galactosidase A enzyme activity. This effect leads to the accumulation of glycosphingolipi…
View article: Effectiveness and tolerability of givosiran for the management of acute hepatic porphyria: A monocenter real-life evaluation
Effectiveness and tolerability of givosiran for the management of acute hepatic porphyria: A monocenter real-life evaluation Open
View article: Prevalence, risk factors, and treatment status of anemia in hospitalized older patients: a focus on differences between Geriatric and Nephrological Hospital Setting in Italy
Prevalence, risk factors, and treatment status of anemia in hospitalized older patients: a focus on differences between Geriatric and Nephrological Hospital Setting in Italy Open
Anemia is a common but often underdiagnosed and undertreated geriatric syndrome in hospitalized older patients. In this retrospective multicenter study, we aimed at characterizing the prevalence, risk factors, diagnostic and treatment appr…
View article: #2990 Prevalence and risk factors of altered control of BP during the night in a large hemodialysis population investigated by 48 hours ABPM
#2990 Prevalence and risk factors of altered control of BP during the night in a large hemodialysis population investigated by 48 hours ABPM Open
Background and Aims Altered BP control during the night (non-dipping, reverse dipping and nocturnal hypertension) is recognized as a powerful risk factor for death and CV events in the hemodialysis (HD) population. However, these alteratio…
View article: #2470 Isolated diastolic hypertension in hemodialysis patients
#2470 Isolated diastolic hypertension in hemodialysis patients Open
Background and Aims Isolated diastolic hypertension (IDH) is relatively rare in the general population (prevalence about 6.5%, Front Cardiovasc Med. 2021;8:810105) and of uncertain etiologic implications. The prevalence of this alteration …
View article: Physical activity and exercise programs for kidney patients: an Italian survey of nephrology centres
Physical activity and exercise programs for kidney patients: an Italian survey of nephrology centres Open
View article: How histopathological diagnosis interacts with kidney ultrasound parameters to predict glomerular filtration rate
How histopathological diagnosis interacts with kidney ultrasound parameters to predict glomerular filtration rate Open
Background eGFR evaluation is a pivotal staging step in patients with chronic kidney disease (CKD), and renal ultrasound plays an important role in diagnosis, prognosis and progression of CKD. The role of the interaction between histopatho…
View article: Reducing agalsidase beta infusion time in Fabry patients: low incidence of antibody formation and infusion-associated reactions in an Italian multicenter study
Reducing agalsidase beta infusion time in Fabry patients: low incidence of antibody formation and infusion-associated reactions in an Italian multicenter study Open
Background Fabry disease is a rare progressive X-linked lysosomal storage disease caused by mutations in the GLA gene that encodes α-galactosidase A. Agalsidase beta is a recombinant enzyme replacement therapy authorized in Europe at a sta…
View article: Italian healthcare resource consumption for patients on hemodialysis treated for chronic kidney disease-associated pruritus (CKD-aP)
Italian healthcare resource consumption for patients on hemodialysis treated for chronic kidney disease-associated pruritus (CKD-aP) Open
Background: Chronic kidney disease-associated pruritus (CKD-aP) affects patients on hemodialysis. This study identified hemodialysis patients presumably affected or not affected by CKD-aP and integrated healthcare costs, from the perspecti…
View article: The International, Prospective Cosmos (Cytosorb® Treatment of Critically Ill Patients) Registry: Interim Results from the First 150 Patients
The International, Prospective Cosmos (Cytosorb® Treatment of Critically Ill Patients) Registry: Interim Results from the First 150 Patients Open
View article: Assessment of bone marrow fat by 3-Tesla magnetic resonance spectroscopy in patients with chronic kidney disease
Assessment of bone marrow fat by 3-Tesla magnetic resonance spectroscopy in patients with chronic kidney disease Open
In CKD patients, PDFF assessed by MRS at lumbar spine is higher than in healthy population, correlates with bone loss assessed by QCT and significantly increases with the worsening of renal function. MRS is a reliable and highly repeatable…
View article: Prescriptive appropriateness of direct oral anticoagulants in older subjects with atrial fibrillation discharged from acute medical wards.
Prescriptive appropriateness of direct oral anticoagulants in older subjects with atrial fibrillation discharged from acute medical wards. Open
Background. Knowledge on the prescriptive practice of direct oral anticoagulants (DOACs) in older subjects with atrial fibrillation (AF) hospitalized in acute medical wards is limited. Objective. To evaluate the prevalence and appropriaten…