Filippo Casoni
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View article: Müller cells trophism and pathology as the next therapeutic targets for retinal diseases
Müller cells trophism and pathology as the next therapeutic targets for retinal diseases Open
Müller cells are a crucial retinal cell type involved in multiple regulatory processes and functions that are essential for retinal health and functionality. Acting as structural and functional support for retinal neurons and photoreceptor…
View article: Altered Ca2+ responses and antioxidant properties in Friedreich's ataxia-like cerebellar astrocytes
Altered Ca2+ responses and antioxidant properties in Friedreich's ataxia-like cerebellar astrocytes Open
Friedreich's ataxia (FRDA) is a neurodegenerative disorder characterized by severe neurological signs, affecting the peripheral and central nervous system, caused by reduced frataxin protein (FXN) levels. Although several studies have high…
View article: Altered calcium responses and antioxidant properties in Friedreich’s ataxia-like cerebellar astrocytes
Altered calcium responses and antioxidant properties in Friedreich’s ataxia-like cerebellar astrocytes Open
Friedreich’s ataxia (FRDA) is a neurodegenerative disorder characterized by severe neurological signs affecting both the peripheral and central nervous system, caused by reduced levels of the frataxin protein (FXN). While several studies h…
View article: A spatial–temporal map of glutamatergic neurogenesis in the murine embryonic cerebellar nuclei uncovers a high degree of cellular heterogeneity
A spatial–temporal map of glutamatergic neurogenesis in the murine embryonic cerebellar nuclei uncovers a high degree of cellular heterogeneity Open
The nuclei are the main output structures of the cerebellum. Each and every cerebellar cortical computation reaches several areas of the brain by means of cerebellar nuclei processing and integration. Nevertheless, our knowledge of these s…
View article: Neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis
Neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis Open
Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease mostly affecting people around 50–60 years of age. TDP-43, an RNA-binding protein involved in pre-mRNA splicing and controlling mRNA stability and trans…
View article: A spatial-temporal map of glutamatergic neurogenesis in embryonic cerebellar nuclei uncovers a high degree of cellular heterogeneity
A spatial-temporal map of glutamatergic neurogenesis in embryonic cerebellar nuclei uncovers a high degree of cellular heterogeneity Open
The nuclei are the main output structures of the cerebellum. Each and every cerebellar cortical computation reaches several areas of the brain by means of CN processing and integration. Nevertheless our knowledge of these structures is sti…
View article: Two neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis
Two neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis Open
Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease mostly affecting people around 50-60 years of age. TDP-43, a ubiquitously expressed RNA-binding protein involved in pre-mRNA splicing and controlling mR…
View article: Cerebellum Lecture: the Cerebellar Nuclei—Core of the Cerebellum
Cerebellum Lecture: the Cerebellar Nuclei—Core of the Cerebellum Open
The cerebellum is a key player in many brain functions and a major topic of neuroscience research. However, the cerebellar nuclei (CN), the main output structures of the cerebellum, are often overlooked. This neglect is because research on…
View article: Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice
Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice Open
Lysosomal acid phosphatase 2 (Acp2) mutant mice (naked-ataxia, nax) have a severe cerebellar cortex defect with a striking reduction in the number of granule cells. Using a combination of in vivo and in vitro immunohistochemistry, Western …
View article: Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum
Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum Open
Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first consider the formation of the upper rhombic lip, fro…
View article: ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus
ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus Open
The choroid plexus (ChP) is a secretory tissue that produces cerebrospinal fluid (CSF) and secretes it into the ventricular system. CSF flows from the lateral to the third ventricle, and then to the fourth ventricle through the cerebral aq…
View article: ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus
ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus Open
The choroid plexus (ChP) is a secretory tissue that produces cerebrospinal fluid (CSF) secreted into the ventricular system. It is a monolayer of secretory, multiciliated epithelial cells derived from neuroepithelial progenitors and overly…
View article: Targeting the ERK Signaling Pathway in Melanoma
Targeting the ERK Signaling Pathway in Melanoma Open
The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its progression have opened a new era in the treatment of this tumor. Vemurafenib was the first specific kinase inhibitor approved for therapy of advanced mela…
View article: Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway
Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway Open
One key signaling pathway known to influence neuronal migration involves the extracellular matrix protein Reelin. Typically, signaling of Reelin occurs via apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor (VLD…
View article: Domain-specific regulation of cerebellar morphogenesis by Zfp423 / ZNF423, a gene implicated in Joubert syndrome and cerebellar vermis hypoplasia
Domain-specific regulation of cerebellar morphogenesis by Zfp423 / ZNF423, a gene implicated in Joubert syndrome and cerebellar vermis hypoplasia Open
The Zfp423 gene encodes a 30-Zn-finger transcription factor that acts as a scaffold for the assembly of complex transcriptional and cellular machineries regulating neural development. While null Zfp423 mutants feature a sharp decrease in t…
View article: <i>Zfp423/ZNF423</i> regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors
<i>Zfp423/ZNF423</i> regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors Open
The Zfp423/ZNF423 gene encodes a 30-zinc-finger transcription factor involved in key developmental pathways. Although null Zfp423 mutants develop cerebellar malformations, the underlying mechanism remains unknown. ZNF423 mutations are asso…
View article: Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains
Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains Open
Fertility in mammals is controlled by hypothalamic neurons that secrete gonadotropin-releasing hormone (GnRH). These neurons differentiate in the olfactory placodes during embryogenesis and migrate from the nose to the hypothalamus before …
View article: Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion
Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion Open
Anti-Müllerian hormone (AMH) plays crucial roles in sexual differentiation and gonadal functions. However, the possible extragonadal effects of AMH on the hypothalamic–pituitary–gonadal axis remain unexplored. Here we demonstrate that a si…