Filippo Massa
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View article: The eIF5A hypusination inhibitor GC7 improves tolerance of pancreatic beta cells to ischemia/reperfusion
The eIF5A hypusination inhibitor GC7 improves tolerance of pancreatic beta cells to ischemia/reperfusion Open
Treatment of rodent beta cell line with GC7, an inhibitor of eIF5A hypusination, reversibly slows down mitochondrial activity and shifts the cells’ energy metabolism toward anaerobic glycolysis. As a result, GC7 treatment transiently inhib…
View article: MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters
MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters Open
Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the h…
View article: Reviewer #2 (Public Review): MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters
Reviewer #2 (Public Review): MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters Open
Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the h…
View article: MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters
MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters Open
Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the h…
View article: Reviewer #1 (Public Review): MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters
Reviewer #1 (Public Review): MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters Open
Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the h…
View article: MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters
MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters Open
Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the h…
View article: Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients Open
Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive d…
View article: Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries
Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries Open
Significance In the mammalian ovary, primordial germ cells maintain a genomic program associated with pluripotency until they stop proliferating, move toward oogenesis, and enter meiosis. The molecular mechanisms that enable primordial ger…
View article: Genetic and Molecular Insights Into Genotype-Phenotype Relationships in Osteopathia Striata With Cranial Sclerosis (OSCS) Through the Analysis of Novel Mouse Wtx Mutant Alleles
Genetic and Molecular Insights Into Genotype-Phenotype Relationships in Osteopathia Striata With Cranial Sclerosis (OSCS) Through the Analysis of Novel Mouse Wtx Mutant Alleles Open
The X-linked WTX/AMER1 protein constitutes an important component of the β-catenin destruction complex that can both enhance and suppress canonical β-catenin signaling. Somatic mutations in WTX/AMER1 have been found in a proportion of the …
View article: Coronary Artery Formation Is Driven by Localized Expression of R-spondin3
Coronary Artery Formation Is Driven by Localized Expression of R-spondin3 Open
Coronary arteries are essential to support the heart with oxygen, and coronary heart disease is one of the leading causes of death worldwide. The coronary arteries form at highly stereotyped locations and are derived from the primitive vas…