Filippo Vascon
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View article: Identification and Characterization of a Small-Molecule Inhibitor of the <i>Pseudomonas aeruginosa</i> SOS Response
Identification and Characterization of a Small-Molecule Inhibitor of the <i>Pseudomonas aeruginosa</i> SOS Response Open
The SOS response is among the most conserved pathways that promote antibiotic resistance onset in bacteria. This study aimed to identify and characterize small-molecule inhibitors of the SOS response in the opportunistic pathogen Pseudo…
View article: Harnessing Photosynthetic ATP for Whole-Cell Biocatalysis in the Cyanobacterium <i>Synechocystis</i>
Harnessing Photosynthetic ATP for Whole-Cell Biocatalysis in the Cyanobacterium <i>Synechocystis</i> Open
Photosynthetic organisms use sunlight to produce ATP and NADPH powering their metabolism. Harnessing these products for driving biocatalytic reactions would enable development of clean and sustainable alternatives for chemical reactions. I…
View article: Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking
Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking Open
View article: Harnessing photosynthetic ATP for whole-cell biocatalysis in the cyanobacterium <i>Synechocystis</i>
Harnessing photosynthetic ATP for whole-cell biocatalysis in the cyanobacterium <i>Synechocystis</i> Open
Photosynthetic organisms use sunlight to produce ATP and NADPH powering their metabolism. Harnessing these products for driving biocatalytic reactions would enable to develop clean and sustainable alternatives for chemical reactions. In th…
View article: Identification and characterization of a small-molecule inhibitor of the <i>Pseudomonas aeruginosa</i> SOS response
Identification and characterization of a small-molecule inhibitor of the <i>Pseudomonas aeruginosa</i> SOS response Open
The SOS response is among the most conserved pathways that promote the acquisition of antibiotic resistance in bacteria. This study aimed to identify and characterize small-molecule inhibitors of the SOS response system in the opportunisti…
View article: Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis
Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis Open
View article: Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance
Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance Open
Mitochondrial calcium (mtCa2+) uptake via the mitochondrial calcium uniporter (MCU) couples calcium homeostasis and energy metabolism. mtCa2+ uptake via MCU is rate-limiting for mitochondrial activation during muscle …
View article: Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking
Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking Open
Macrocyclic peptides provide an attractive modality for drug development due to their ability to bind challenging targes, their small size, and amenability to powerful in vitro evolution techniques such as phage or mRNA display. While thes…
View article: Screening of Small-Molecule Libraries Using SARS-CoV-2-Derived Sequences Identifies Novel Furin Inhibitors
Screening of Small-Molecule Libraries Using SARS-CoV-2-Derived Sequences Identifies Novel Furin Inhibitors Open
SARS-CoV-2 is the pathogen responsible for the most recent global pandemic, which has claimed hundreds of thousands of victims worldwide. Despite remarkable efforts to develop an effective vaccine, concerns have been raised about the actua…
View article: Snapshots of<i>Pseudomonas aeruginosa</i>SOS response activation complex reveal structural prerequisites for LexA engagement and cleavage
Snapshots of<i>Pseudomonas aeruginosa</i>SOS response activation complex reveal structural prerequisites for LexA engagement and cleavage Open
Antimicrobial resistance represents a major threat to human health and Pseudomonas aeruginosa stands out among the pathogens responsible for this emergency. The SOS response to DNA damage plays a pivotal role in bacterial evolution, drivin…
View article: Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-β-Lactamases and Synergistic Activity on Resistant Bacteria
Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-β-Lactamases and Synergistic Activity on Resistant Bacteria Open
The worldwide emergence and dissemination of Gram-negative bacteria expressing metallo-β-lactamases (MBLs) menace the efficacy of all β-lactam antibiotics, including carbapenems, a last-line treatment usually restricted to severe pneumonia…
View article: Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates Open
Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to preserve these important antibacterial drugs. Here, we descri…
View article: Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway
Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway Open
View article: Investigation of the Interaction between Human Serum Albumin and Branched Short-Chain Perfluoroalkyl Compounds
Investigation of the Interaction between Human Serum Albumin and Branched Short-Chain Perfluoroalkyl Compounds Open
The current trend dealing with the production of per- and polyfluoroalkyl substances (PFASs) involves the shifting toward branched short-chain fluorinated compounds known as new-generation PFASs. A key aspect to be clarified, to address th…
View article: The Family Keeps on Growing: Four Novel Fungal OYEs Characterized
The Family Keeps on Growing: Four Novel Fungal OYEs Characterized Open
Aiming at expanding the portfolio of Old Yellow Enzymes (OYEs), which have been systematically studied to be employed in the chemical and pharmaceutical industries as useful biocatalysts, we decided to explore the immense reservoir of fila…
View article: Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design
Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design Open