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View article: Supplementary Figure 2 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Figure 2 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Tukey boxplot of large bowel polyp numbers
View article: Supplementary Table 10 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 10 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Ratio of mean counts for effect of treatment, week and carry-over on tattoo 1 polyp burden in the large bowel PP population
View article: Supplementary Table 11 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 11 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Ratio of mean counts for effect of treatment, week and carry-over on tattoo 1 polyp burden in the large bowel ITT population
View article: Supplementary Table 16 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 16 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Mean differences for effects of treatment and time point on fiber and calcium intake after accounting for age group and surgery type in ITT population.
View article: Supplementary Table 19 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 19 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Adverse events and their relationship to study interventions
View article: Supplementary Table 17 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 17 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Faecal parameters of participants while consuming HAMSB and LAMS
View article: Supplementary Table 13 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 13 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Ratio of mean counts for effect of treatment, week and carry-over on tattoo 2 polyp burden in the large bowel PP population
View article: Supplementary Table 9 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 9 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Ratio of mean counts for effect of treatment, week and carry-over on global polyp burden in the large bowel ITT population
View article: Supplementary Table 18 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 18 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Severity of adverse events by system organ class and treatment sequence
View article: Supplementary Table 7 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 7 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Ratio of mean counts for effect of treatment, week and carry-over on global polyp burden in the large bowel excluding participants with video issues ITT population
View article: Supplementary Table 20 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 20 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Clinically significant clinical laboratory evaluations and other assessments
View article: Supplementary Table 21 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 21 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Summary of protocol deviations
View article: Supplementary Table 5 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 5 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Descriptive statistics for polyp counts of each size in tattoo 1 and 2 in the per protocol population
View article: Supplementary Materials 3 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Materials 3 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Gastrointestinal quality of life questionnaire questions
View article: Supplementary Figure 1 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Figure 1 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Consolidated Standards of Reporting Trials (CONSORT) diagram shows the flow of participants through the trial from enrolment to data analysis.
View article: Data from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Data from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Butyrate may reduce the risk of colorectal cancer and can be delivered to the colon using butyrylated high-amylose maize starch (HAMSB). This trial evaluated the effects of HAMSB on polyp burden in participants with familial adenomatous po…
View article: Supplementary Materials 1 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Materials 1 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Study protocol
View article: Supplementary Table 12 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 12 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Ratio of mean counts for effect of treatment, week and carry-over on tattoo 2 polyp burden in the large bowel ITT population
View article: Supplementary Table 3 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 3 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Descriptive statistics for polyp counts of each size in the large bowel in the per protocol population
View article: Supplementary Table 15 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 15 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Dietary intake by ITT population during each intervention period compared to Australian daily macronutrient intake
View article: Supplementary Table 8 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 8 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Ratio of mean counts for effect of treatment, week and carry-over on global polyp burden in the large bowel PP population
View article: Supplementary Table 4 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 4 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Descriptive statistics for polyp counts of each size in tattoo 1 and 2 in the intention to treat population
View article: Supplementary Table 6 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 6 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Ratio of mean counts for effect of treatment, week and carry-over on global polyp burden in the large bowel excluding polyps 6-10 mm in size ITT population
View article: Supplementary Table 14 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 14 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Mean difference for effects of treatment and time point on modified gastrointestinal quality of life index
View article: Supplementary Table 1 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 1 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Representativeness of study participants table
View article: Supplementary Materials 2 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Materials 2 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Statistical analysis plan
View article: Supplementary Table 2 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
Supplementary Table 2 from The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Descriptive statistics for polyp counts of each size in the large bowel intention to treat population
View article: Tumour spectrum, distinguishing features and management recommendations for NTHL1-associated tumour syndrome: a systematic review
Tumour spectrum, distinguishing features and management recommendations for NTHL1-associated tumour syndrome: a systematic review Open
Background and aim To systematically describe the genotypes and phenotypes of NTHL1-associated tumour syndrome (NATS) cases reported in the literature. Methods A systematic review of literature across Medline, Embase and Web of Science was…
View article: Treatment‐Refractory Tracheobronchitis in Crohn's Disease: A Rare Pulmonary Manifestation of Inflammatory Bowel Disease
Treatment‐Refractory Tracheobronchitis in Crohn's Disease: A Rare Pulmonary Manifestation of Inflammatory Bowel Disease Open
Large airway inflammation is a rare and under‐recognised pulmonary manifestation of Crohn's disease. It is associated with significant morbidity and occurs independent of intestinal disease activity. Inflammation of the trachea and bronchi…
View article: The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial
The Effect of Butyrylated Starch on Bowel Polyps in Familial Adenomatous Polyposis: Results of a Randomized, Double-blind, Placebo-Controlled Crossover Trial Open
Butyrate may reduce the risk of colorectal cancer and can be delivered to the colon using butyrylated high-amylose maize starch (HAMSB). This trial evaluated the effects of HAMSB on polyp burden in participants with familial adenomatous po…