Finn Hinrichsen
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View article: Long-Term Intestinal Epithelial Remodeling Induced by Acute Protein-Energy Malnutrition
Long-Term Intestinal Epithelial Remodeling Induced by Acute Protein-Energy Malnutrition Open
Protein-energy malnutrition (PEM) is a global health burden with lasting effects that extend well beyond the initial nutrient deficiency. To systematically investigate the long-term effects of a single episode of PEM on the structure and f…
View article: Atg16l1 and Xbp1 cooperatively protect from transcription-associated mutagenesis and small intestinal carcinogenesis
Atg16l1 and Xbp1 cooperatively protect from transcription-associated mutagenesis and small intestinal carcinogenesis Open
View article: P142 Genetic ablation of DNA methyltransferase 3A in myeloid cells impairs M1/M2 polarization and leads to pro-inflammatory macrophages
P142 Genetic ablation of DNA methyltransferase 3A in myeloid cells impairs M1/M2 polarization and leads to pro-inflammatory macrophages Open
Background Genetic variants in the de novo DNA methyltransferase DNMT3A associate with increased risk for inflammatory bowel disease (IBD). While DNMT3A loss-of-function somatic mutations have been attributed to myelodysplasia and acute my…
View article: DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon
DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon Open
View article: Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis Open
View article: Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis Open
Summary Hexokinases (HK) catalyze the first step of glycolysis and thereby limit its pace. HK2 is highly expressed in the gut epithelium, plays a role in immune responses and is upregulated in inflammation and ulcerative colitis 1–3 . Here…
View article: Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19 Open
View article: Nutritional Targeting of the Microbiome as Potential Therapy for Malnutrition and Chronic Inflammation
Nutritional Targeting of the Microbiome as Potential Therapy for Malnutrition and Chronic Inflammation Open
Homeostatic interactions with the microbiome are central for a healthy human physiology and nutrition is the main driving force shaping the microbiome. In the past decade, a wealth of preclinical studies mainly using gnotobiotic animal mod…
View article: Longitudinal multi-omics analysis identifies responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories
Longitudinal multi-omics analysis identifies responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories Open
The pandemic spread of the potentially life-threatening disease COVID-19 requires a thorough understanding of the longitudinal dynamics of host responses. Temporal resolution of cellular features associated with a severe disease trajectory…
View article: Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress
Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress Open