Fiona Bartoli
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View article: Contribution of endothelial Piezo1 in mechanically induced muscle hypertrophy
Contribution of endothelial Piezo1 in mechanically induced muscle hypertrophy Open
Piezo1 proteins form nonselective cation channels with key roles in endothelial responses to mechanical forces. Here we reveal that endothelial Piezo1 regulates skeletal muscle hypertrophy following mechanical overload. Using a conditional…
View article: PIEZO Force Sensors and the Heart
PIEZO Force Sensors and the Heart Open
The PIEZO1 and PIEZO2 membrane proteins form uniquely structured calcium permeable nonselective cation channels dedicated to mechanical force sensing in eukaryotic cells. In this review of the scientific literature, we address PIEZOs in th…
View article: <i>PIEZO1</i> variant implications for biological understanding and human health
<i>PIEZO1</i> variant implications for biological understanding and human health Open
The large membrane protein PIEZO1 assembles as trimers to form exceptional mechanical force-sensing ion channels of eukaryotes. When these channels are activated by force, cell membrane permeability to calcium ions and other ions increases…
View article: Endothelial force sensing signals to parenchymal cells to regulate bile and plasma lipids
Endothelial force sensing signals to parenchymal cells to regulate bile and plasma lipids Open
How cardiovascular activity interacts with lipid homeostasis is incompletely understood. We postulated a role for blood flow acting at endothelium in lipid regulatory organs. Transcriptome analysis was performed on livers from mice enginee…
View article: PIEZO1 force sensing controls global lipid homeostasis
PIEZO1 force sensing controls global lipid homeostasis Open
How cardiovascular activity beneficially regulates lipid homeostasis is unclear. Here we hypothesise a mechanism in which mechanical force sensed by PIEZO1 ion channels in endothelium links blood flow to lipid regulation. We engineered mic…
View article: Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1
Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1 Open
Background and Purpose The protein PIEZO1 forms mechanically activated, calcium‐permeable, non‐selective cation channels in numerous cell types from several species. Options for pharmacological modulation are limited and so we modified a s…
View article: Global PIEZO1 Gain-of-Function Mutation Causes Cardiac Hypertrophy and Fibrosis in Mice
Global PIEZO1 Gain-of-Function Mutation Causes Cardiac Hypertrophy and Fibrosis in Mice Open
PIEZO1 is a subunit of mechanically-activated, nonselective cation channels. Gain-of-function PIEZO1 mutations are associated with dehydrated hereditary stomatocytosis (DHS), a type of anaemia, due to abnormal red blood cell function. Here…
View article: Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells
Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells Open
Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cul…
View article: Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca <sup>2+</sup> Handling After Pressure Overload
Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca <sup>2+</sup> Handling After Pressure Overload Open
Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca 2+ entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key contributor of cardiac hypertrophy and heart failure but the …
View article: Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes
Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes Open
Whereas cardiac TRPC (transient receptor potential canonical) channels and the associated store-operated Ca2+ entry (SOCE) are abnormally elevated during cardiac hypertrophy and heart failure, the mechanism of this upregulation is not full…
View article: Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies
Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies Open
Endothelial cells selectively release cargo stored in Weibel-Palade bodies (WPBs) to regulate vascular function, but the underlying mechanisms are poorly understood. Here we show that histamine evokes the release of the proinflammatory lig…