Explanipedia

Qualitative evaluation of rapid implementation of remote blood pressure self-monitoring in pregnancy during Covid-19 Open

Charlotte Paterson, Elaine Jack, Brian McKinstry, Sonia Whyte, Fiona C. Denison , et al. · 2023

In March 2020, the World Health Organisation named the severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2), which causes corona virus disease 2019 (COVID –19), as a pandemic. Pregnant women were considered at increased risk of dev…

Review of investigational medical devices' clinical trials and regulations in Africa as a benchmark for new innovations Open

Brian Matovu, Mercy Takuwa, Charles Norman Mpaata, Fiona C. Denison, Noah Kiwanuka , et al. · 2022

Medical technologies present a huge potential in improving global health playing a key role toward achieving Sustainable Development Goal 3 by 2030. A number of clinicians, innovators, business entities and biomedical engineers among other…

Severe maternal morbidity in Scotland Open

John A Masterson, Imad Adamestam, Monika Beatty, James P. Boardman, P. Johnston , et al. · 2022

Summary Using a cohort study design, we analysed 17 diagnoses and 9 interventions (including critical care admission) as a composite measure of severe maternal morbidity for pregnancies recorded over 14 years in Scotland. There were 762,91…

Pregnancy and the SARS-CoV-2 pandemic Open

Rebecca M. Reynolds, Sarah J. Stock, Fiona C. Denison, Jacqueline A. Maybin, Hilary Critchley · 2022

[Figure: see text]

Gene expression profiling of placentae from women with obesity and obstructive sleep apnoea Open

Emma Johns, Daniel L. Halligan, Triin Tammsalu, Elizabeth A. Hill, Renata L. Riha , et al. · 2022

High prevalence of obstructive sleep apnea in pregnant women with class III obesity: a prospective cohort study Open

Emma Johns, Elizabeth A. Hill, Stevie Williams, Abdelkebir Sabil, Renata L. Riha , et al. · 2021

Metformin in obese pregnancy has no adverse effects on cardiovascular risk in early childhood Open

Yang Liu, Lauren Lacey, Sonia Whyte, Siobhan Quenby, Fiona C. Denison , et al. · 2021

Metformin is widely used in pregnancy, despite lack of long-term safety for children. We hypothesised that metformin exposure in utero is associated with increased cardiovascular risk. We tested this hypothesis in a follow-up study of chil…

Options in Pregnancy to Increase ActiveLy Sitting (OPALS) Feasibility Study Open

Caterina Fazzi, Fiona C. Denison, David H. Saunders, Jane E. Norman, Rebecca M. Reynolds · 2021

Background. A negative association between obesity and pregnancy outcomes has been described, as well as between time sedentary and pregnancy outcomes. Most interventions based on physical activity involving obese pregnant women have faile…

First and second pregnancy outcomes in women with class III obesity: An observational cohort study Open

Elizabeth Wastnedge, Janey Fretwell, Emma Johns, Fiona C. Denison, Rebecca M. Reynolds · 2021

Cervical ripening at home or in-hospital-prospective cohort study and process evaluation (CHOICE) study: a protocol. Open

Sarah J. Stock, A. Bhide, Heather Richardson, Mairead Black, Cassandra Yuill , et al. · 2021

IntroductionThe aim of the cervical ripening at home or in-hospital-prospective cohort study and process evaluation (CHOICE) study is to compare home versus in-hospital cervical ripening to determine whether home cervical ripening is safe …

Cervical ripening at home or in-hospital—prospective cohort study and process evaluation (CHOICE) study: a protocol Open

Sarah J. Stock, A. Bhide, Heather Richardson, Mairead Black, Cassandra Yuill , et al. · 2021

Introduction The aim of the cervical ripening at home or in-hospital—prospective cohort study and process evaluation (CHOICE) study is to compare home versus in-hospital cervical ripening to determine whether home cervical ripening is safe…

Pregnancy and COVID-19 Open

Elizabeth Wastnedge, Rebecca M. Reynolds, Sara R. van Boeckel, Sarah J. Stock, Fiona C. Denison , et al. · 2020

There are many unknowns for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. Clinical experience of pregnancies complicated with infection by other coronaviruses e.g., Severe Acute Respiratory Syndrome (SARS) and Mid…

Gestational diabetes: opportunities for improving maternal and child health Open

Ponnusamy Saravanan, Laura A. Magee, Anita Banerjee, Matthew A. Coleman, Peter von Dadelszen , et al. · 2020

Gestational diabetes: opportunities for improving maternal and child health Open

Ponnusamy Saravanan, Laura A. Magee, Anita Banerjee, Matthew A. Coleman, Peter von Dadelszen , et al. · 2020

Staff and patient perceptions of a community urinary catheter service Open

Freya Oswald, Ellen Young, Fiona C. Denison, Rosalind J. Allen, Meghan Perry · 2020

Urinary catheters are used extensively throughout healthcare for various reasons including management of urinary tract dysfunction. The purpose of this study was to simultaneously explore both catheter user experience and staff perception …

Correction: A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1) Open

Ibtisam M. Abokhrais, Fiona C. Denison, Lucy Whitaker, Philippa T. K. Saunders, Ann Doust , et al. · 2020

[This corrects the article DOI: 10.1371/journal.pone.0227695.].

Sleep disordered breathing in pregnancy: A review of the pathophysiology of adverse pregnancy outcomes Open

Emma Johns, Fiona C. Denison, Rebecca M. Reynolds · 2020

Sleep disordered breathing (SDB) is a common obesity‐related co‐morbidity with strong associations to cardiometabolic disease. The risk of SDB is increased during pregnancy, particularly among obese pregnant women. Accumulating evidence su…

A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1) Open

Ibtisam M. Abokhrais, Fiona C. Denison, Lucy Whitaker, Philippa T. K. Saunders, Ann Doust , et al. · 2020

[This corrects the article DOI: 10.1371/journal.pone.0227695.].

Face Coverings, Aerosol Dispersion and Mitigation of Virus Transmission Risk. Dataset 2: raw and processed data for tests 1 - 90 Open

Ignazio Maria Viola, Brian Peterson, Gabriele Pisetta, Geethanjali Pavar, Hibbah Akhtar , et al. · 2020

"Face Coverings, Aerosol Dispersion and Mitigation of Virus Transmission Risk" Supplementary Information. The information is grouped into four, zipped, datasets, all of which contain the same ReadMe.txt and SupplementaryMaterialIndex.xlsx …

Face Coverings, Aerosol Dispersion and Mitigation of Virus Transmission Risk. Dataset 1: videos, images and spirometry results Open

Ignazio Maria Viola, Brian Peterson, Gabriele Pisetta, Geethanjali Pavar, Hibbah Akhtar , et al. · 2020

"Face Coverings, Aerosol Dispersion and Mitigation of Virus Transmission Risk" Supplementary Information. The information is grouped into four, zipped, datasets, all of which contain the same ReadMe.txt and SupplementaryMaterialIndex.xlsx …

Nitroglycerin for treatment of retained placenta: A randomised, placebo-controlled, multicentre, double-blind trial in the UK Open

Fiona C. Denison, Kathryn Carruthers, Jemma Hudson, Gladys McPherson, Gin Nie Chua , et al. · 2019

ISRCTN.com ISRCTN88609453 ClinicalTrials.gov NCT02085213.

Glyceryl trinitrate to reduce the need for manual removal of retained placenta following vaginal delivery: the GOT-IT RCT Open

Fiona C. Denison, Kathryn Carruthers, Jemma Hudson, Gladys McPherson, Graham Scotland , et al. · 2019

Background Retained placenta is associated with postpartum haemorrhage and can lead to significant maternal morbidity if untreated. The only effective treatment is the surgical procedure of manual removal of placenta, which is costly, requ…

Predictors of surgical site skin infection and clinical outcome at caesarean section in the very severely obese: A retrospective cohort study Open

Michael Dias, A. Dick, Rebecca M. Reynolds, Marius Lahti‐Pulkkinen, Fiona C. Denison · 2019

SSSI rates are high in very severely obese women following caesarean section, regardless of location of skin incision.

Healthy weight in pregnancy: time for a shift in approach? Open

A. A. Brown, Rebecca M. Reynolds, Fiona C. Denison · 2019

Obesity is one of the biggest challenges facing global reproductive health. Women in the UK and USA are today more likely to be obese or overweight at booking than normal weight, and many low- and middle-income countries (LMICs) seem desti…

The impact of maternal obesity in pregnancy on placental glucocorticoid and macronutrient transport and metabolism Open

Emma Johns, Fiona C. Denison, Rebecca M. Reynolds · 2019

Care of Women with Obesity in Pregnancy Open

Fiona C. Denison, NR Aedla, Oonagh Keag, Kahyee Hor, Rebecca M. Reynolds , et al. · 2018

What care should be provided in the primary care setting to women of childbearing age with obesity who wish to become pregnant? Primary care services should ensure that all women of childbearing age have the opportunity to optimise their w…

Maternal antenatal daytime sleepiness and child neuropsychiatric and neurocognitive development Open

Marius Lahti‐Pulkkinen, Theresia Mina, Renata L. Riha, Katri Räikkönen, Anu‐Katriina Pesonen , et al. · 2018

Background The prevalence of sleep problems among pregnant women is over 50%, and daytime sleepiness is among the most common sleep problems. Previous studies have associated antenatal sleep problems with adverse maternal health and neonat…

Gestational Diabetes Mellitus: Mechanisms, Treatment, and Complications Open

Emma Johns, Fiona C. Denison, Jane E. Norman, Rebecca M. Reynolds · 2018

Early screening and treatment of gestational diabetes in high-risk women improves maternal and neonatal outcomes: A retrospective clinical audit Open

David Ryan, Laura Haddow, Aksha Ramaesh, Rod Kelly, Emma Johns , et al. · 2018

Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review Open

Gerard Cummins, Jessica Kremer, Anne L. Bernassau, Andrew Brown, Helen Bridle , et al. · 2018

This article reviews existing clinical practices and sensor research undertaken to monitor fetal well-being during labour. Current clinical practices that include fetal heart rate monitoring and fetal scalp blood sampling are shown to be e…

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