Fei Tang
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View article: Remodeling of T and endothelial cells during total neoadjuvant therapy in rectal cancer
Remodeling of T and endothelial cells during total neoadjuvant therapy in rectal cancer Open
Total neoadjuvant therapy (TNT) is a standard care for locally advanced rectal cancer (LARC), yet the immune remodeling mechanisms underlying its efficacy remain unclear. Using single-cell RNA, T cell receptor, and spatial transcriptome se…
View article: Mechanistic insights into IL-1β-mediated progression of tendinopathy
Mechanistic insights into IL-1β-mediated progression of tendinopathy Open
Tendinopathy, a chronic degenerative musculoskeletal disorder characterized by pain, edema, and functional impairment, exhibits increased prevalence among elderly populations and athletes. Despite extensive research efforts targeting the a…
View article: Lower cancer incidence three years after COVID-19 infection in a large veteran population
Lower cancer incidence three years after COVID-19 infection in a large veteran population Open
Background The role of COVID-19 infection in cancer incidence risk is not known. COVID-19 infection may lead to increased cancer risk, as seen with other viruses, or to decreased risk due to the activation of the immune response during acu…
View article: RETRACTED: Yuan et al. Green Remanufacturer’s Mixed Collection Channel Strategy Considering Enterprise’s Environmental Responsibility and the Fairness Concern in Reverse Green Supply Chain. Int. J. Environ. Res. Public Health 2021, 18, 3405
RETRACTED: Yuan et al. Green Remanufacturer’s Mixed Collection Channel Strategy Considering Enterprise’s Environmental Responsibility and the Fairness Concern in Reverse Green Supply Chain. Int. J. Environ. Res. Public Health 2021, 18, 3405 Open
The journal retracts the article “Green Remanufacturer’s Mixed Collection Channel Strategy Considering Enterprise’s Environmental Responsibility and the Fairness Concern in Reverse Green Supply Chain” [...]
View article: Mechanisms of Magnoliae Officinalis Cortex Volatile Oil in Alleviating 5-Fluorouracil-Induced Mucositis via Multi-Omics Approaches
Mechanisms of Magnoliae Officinalis Cortex Volatile Oil in Alleviating 5-Fluorouracil-Induced Mucositis via Multi-Omics Approaches Open
MagO mitigated CIM by modulating the PI3K/AKT signaling pathway and the PGE2/EP2/EP4 axis, restoring gut microbiota and metabolites composition, reducing apoptosis, and improving intestinal permeability.
View article: GUI-G$^2$: Gaussian Reward Modeling for GUI Grounding
GUI-G$^2$: Gaussian Reward Modeling for GUI Grounding Open
Graphical User Interface (GUI) grounding maps natural language instructions to precise interface locations for autonomous interaction. Current reinforcement learning approaches use binary rewards that treat elements as hit-or-miss targets,…
View article: Impact of Long-Term Care Insurance on health out-of-pocket expenditure ratios for older adults
Impact of Long-Term Care Insurance on health out-of-pocket expenditure ratios for older adults Open
Background China's rapidly aging population has intensified the demand for long-term care (LTC), resulting in higher out-of-pocket expenditure (OOPE) ratios and financial strain among older adults. To mitigate these burdens, Long-Term Care…
View article: Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids Open
Liver fibrosis remains a critical health concern with limited therapeutic options. Kaempferol (Kae) is a natural flavonoid widely present in natural plants, yet its role in modulating gut–liver axis interactions during fibrosis is unexplor…
View article: Determinants of Foot Care Adherence Among High-Risk Diabetic Populations: Insights From an Ethnic Minority Community Study in Southwest China
Determinants of Foot Care Adherence Among High-Risk Diabetic Populations: Insights From an Ethnic Minority Community Study in Southwest China Open
Background: Effective foot care is crucial for preventing diabetic foot ulcers (DFU). While previous studies have identified general determinants of foot care adherence, the unique challenges faced by ethnic minority communities in rural s…
View article: Prediction of postoperative vault after implantable collamer lens implantation with deep learning
Prediction of postoperative vault after implantable collamer lens implantation with deep learning Open
AIM: To predict the post-operative vault and the suitable size of the implantable collamer lens (ICL) by comparing the performance of multiple artificial intelligence (AI) algorithms. METHODS: A retrospective analysis of 83 patients with 1…
View article: The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis Open
Fibrosis, characterized by abnormal deposition of structural proteins, is a major cause of tissue dysfunction in chronic diseases. The disease burden associated with progressive fibrosis is substantial, and currently approved drugs are una…
View article: Alcoholic cirrhosis-associated immune dysfunction: What does it imply for us?
Alcoholic cirrhosis-associated immune dysfunction: What does it imply for us? Open
Alcoholic cirrhosis is a leading cause of chronic advanced liver disease. With the gradual eradication of viral hepatitis and the rising levels of alcohol consumption, the incidence of alcoholic cirrhosis is expected to increase steadily. …
View article: Diagnosis of Mycoplasma Hominis Peritonitis in a CAPD Patient with Metagenomic Next-Generation Sequencing: A Case Report
Diagnosis of Mycoplasma Hominis Peritonitis in a CAPD Patient with Metagenomic Next-Generation Sequencing: A Case Report Open
Patients with culture-negative PD-associated peritonitis or refractory peritonitis should be evaluated for potential Mh infection. mNGS enables rapid detection of pathogens that traditional methods may fail to identify. A combination of mo…
View article: Discussion on the duration of response following HBsAg clearance in patients with chronic hepatitis B treated with PegIFNα-2b
Discussion on the duration of response following HBsAg clearance in patients with chronic hepatitis B treated with PegIFNα-2b Open
Aim Functional cure strategies based on interferon therapy for chronic hepatitis B (CHB) are gaining increasing attention among clinicians. However, studies investigating the duration of response after achieving HBsAg clearance with interf…
View article: Where lung cancer and tuberculosis intersect: recent advances
Where lung cancer and tuberculosis intersect: recent advances Open
Lung cancer (LC) and tuberculosis (TB) represent two major global public health issues. Prior evidence has suggested a link between TB infection and an increased risk of LC. As advancements in LC treatment have led to extended survival rat…
View article: A Survey on (M)LLM-Based GUI Agents
A Survey on (M)LLM-Based GUI Agents Open
Graphical User Interface (GUI) Agents have emerged as a transformative paradigm in human-computer interaction, evolving from rule-based automation scripts to sophisticated AI-driven systems capable of understanding and executing complex in…
View article: Post-Viral Frailty in Long COVID: A Distinct Phenotype within Veterans
Post-Viral Frailty in Long COVID: A Distinct Phenotype within Veterans Open
Background Long COVID is characterized by persistent symptoms affecting one or more organ systems for at least 3 months following a SARS-CoV-2 infection. The pathophysiologic mechanisms of this complex disease are poorly understood. Beyond…
View article: Lower Cancer Incidence Three Years After COVID-19 Infection in a Large Veteran Population
Lower Cancer Incidence Three Years After COVID-19 Infection in a Large Veteran Population Open
Background The role of COVID-19 infection in cancer incidence risk is not known. COVID-19 infection could lead to increased cancer risk, as seen with other viruses, or it could lead to decreased risk due to the activation of the immune res…
View article: Exploring using HBsAg to predict interferon treatment course to achieve clinical cure in chronic hepatitis B patients: a clinical study
Exploring using HBsAg to predict interferon treatment course to achieve clinical cure in chronic hepatitis B patients: a clinical study Open
Objective Although pegylated interferon α-2b (PEG-IFN α-2b) therapy for chronic hepatitis B has received increasing attention, determining the optimal treatment course remains challenging. This research aimed to develop an efficient model …
View article: Health-related quality of life analysis from ENTER, a randomized, controlled phase III trial of whole-brain radiotherapy with and without concurrent erlotinib in NSCLC with brain metastases
Health-related quality of life analysis from ENTER, a randomized, controlled phase III trial of whole-brain radiotherapy with and without concurrent erlotinib in NSCLC with brain metastases Open
ClinicalTrials.gov identifier: NCT01887795.
View article: Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans
Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans Open
The outbreaks of severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2 highlight the need for countermeasures to prevent future coronavirus pandemics. Given the …
View article: GaVaMoE: Gaussian-Variational Gated Mixture of Experts for Explainable Recommendation
GaVaMoE: Gaussian-Variational Gated Mixture of Experts for Explainable Recommendation Open
Large language model-based explainable recommendation (LLM-based ER) systems show promise in generating human-like explanations for recommendations. However, they face challenges in modeling user-item collaborative preferences, personalizi…
View article: 6809 Natural History Of Classic Congenital Adrenal Hyperplasia: Results From Pediatric And Adult Patients In The CAHtalog Registry
6809 Natural History Of Classic Congenital Adrenal Hyperplasia: Results From Pediatric And Adult Patients In The CAHtalog Registry Open
Disclosure: P.C. White: Consulting Fee; Self; Neurocrine Biosciences, Inc.. Research Investigator; Self; Neurocrine Biosciences, Inc. G.P. Sen: Employee; Self; Neurocrine Biosciences, Inc. F. Tang: Employee; Self; Cytel. J. Chen: Employee;…
View article: Anisodamine (654-1/654-2) ameliorates septic kidney injury in rats by inhibiting inflammation and apoptosis
Anisodamine (654-1/654-2) ameliorates septic kidney injury in rats by inhibiting inflammation and apoptosis Open
Introduction To investigate the protective effects of anisodamine (654-1/654-2) against acute kidney injury (AKI) in LPS-induced septic shock rats and explore its molecular mechanisms. Methods 56 rats were randomly divided into 8 groups: c…
View article: Endothelial dysfunction: Pathophysiology and therapeutic targets for sepsis-induced multiple organ dysfunction syndrome
Endothelial dysfunction: Pathophysiology and therapeutic targets for sepsis-induced multiple organ dysfunction syndrome Open
Sepsis and septic shock are critical medical conditions characterized by a systemic inflammatory response to infection, significantly contributing to global mortality rates. The progression to multiple organ dysfunction syndrome (MODS) rep…