Fiona Cole
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View article: Brownian DNA Computing
Brownian DNA Computing Open
Silicon-based computing faces limitations in energy consumption, parallelism and the possibility to interact with living systems, prompting interest in biomolecular alternatives such as DNA computing. Here we present Brownian DNA computing…
View article: Modulating transformation of DNA origami nanoarray via sequence design
Modulating transformation of DNA origami nanoarray via sequence design Open
The four-way DNA junction is the most prevalent structural motif in DNA nanotechnology. Recently, a reconfigurable DNA nanoarray (domino array) was created with this basic motif to realize intricate, stepwise transformation by the informat…
View article: Minimally Invasive DNA-Mediated Photostabilization for Extended Single-Molecule and Super-resolution Imaging
Minimally Invasive DNA-Mediated Photostabilization for Extended Single-Molecule and Super-resolution Imaging Open
Photobleaching of fluorescence labels poses a major limitation in single-molecule and super-resolution microscopy. Conventional photostabilization methods, such as oxygen removal and addition of high concentrations of photostabilization ad…
View article: Controlled mechanochemical coupling of anti-junctions in DNA origami arrays
Controlled mechanochemical coupling of anti-junctions in DNA origami arrays Open
Allostery is a hallmark of cellular function and important in every biological system. Still, we are only starting to mimic it in the laboratory. Here, we introduce an approach to study aspects of allostery in artificial systems. We use a …
View article: Super-Resolved FRET and Co-Tracking in pMINFLUX
Super-Resolved FRET and Co-Tracking in pMINFLUX Open
Summary Single-molecule FRET (smFRET) is widely used to investigate dynamic (bio) molecular interactions taking place over distances of up to 10 nm. With the advent of recent super-resolution methods such as MINFLUX, MINSTED or RASTMIN, th…
View article: Combining pMINFLUX, graphene energy transfer and DNA-PAINT for nanometer precise 3D super-resolution microscopy
Combining pMINFLUX, graphene energy transfer and DNA-PAINT for nanometer precise 3D super-resolution microscopy Open
3D super-resolution microscopy with nanometric resolution is a key to fully complement ultrastructural techniques with fluorescence imaging. Here, we achieve 3D super-resolution by combining the 2D localization of pMINFLUX with the axial i…
View article: Single antibody detection in a DNA origami nanoantenna
Single antibody detection in a DNA origami nanoantenna Open