Fiona E. Freeman
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View article: Enhancing the Effectiveness of Chemotherapy in Osteosarcoma by Targeting Tumour‐Associated Macrophages (TAMs) through STING Activation
Enhancing the Effectiveness of Chemotherapy in Osteosarcoma by Targeting Tumour‐Associated Macrophages (TAMs) through STING Activation Open
Osteosarcoma is an aggressive pediatric, adolescent, and young adult bone cancer with an immunosuppressive tumor microenvironment (TME) that limits immunotherapy efficacy. Tumor‐associated macrophages, key players in immunosuppression and …
View article: A preclinical assessment of rapidly isolated chondro-progenitor cells from the infrapatellar fat pad for single-stage articular cartilage regeneration
A preclinical assessment of rapidly isolated chondro-progenitor cells from the infrapatellar fat pad for single-stage articular cartilage regeneration Open
Background: Clinically approved cell-based cartilage repair products are associated with multiple surgeries and high cost. There is therefore an unmet clinical need for a cell-based approach that is efficacious and cost effective that can …
View article: Make it STING: nanotechnological approaches for activating cGAS/STING as an immunomodulatory node in osteosarcoma
Make it STING: nanotechnological approaches for activating cGAS/STING as an immunomodulatory node in osteosarcoma Open
Osteosarcoma is a highly aggressive bone cancer primarily affecting children, adolescents, and young adults. The current gold standard for treatment of osteosarcoma patients consists of two to three rounds of chemotherapy, followed by exte…
View article: Utilizing 3D Models to Unravel the Dynamics of Myeloma Plasma Cells’ Escape from the Bone Marrow Microenvironment
Utilizing 3D Models to Unravel the Dynamics of Myeloma Plasma Cells’ Escape from the Bone Marrow Microenvironment Open
Recent therapeutic advancements have markedly increased the survival rates of individuals with multiple myeloma (MM), doubling survival compared to pre-2000 estimates. This progress, driven by highly effective novel agents, suggests a grow…
View article: Localized Nanoparticle‐Mediated Delivery of miR‐29b Normalizes the Dysregulation of Bone Homeostasis Caused by Osteosarcoma whilst Simultaneously Inhibiting Tumor Growth
Localized Nanoparticle‐Mediated Delivery of miR‐29b Normalizes the Dysregulation of Bone Homeostasis Caused by Osteosarcoma whilst Simultaneously Inhibiting Tumor Growth Open
Patients diagnosed with osteosarcoma undergo extensive surgical intervention and chemotherapy resulting in dismal prognosis and compromised quality of life owing to poor bone regeneration, which is further compromised with chemotherapy del…
View article: Localized nanoparticle-mediated delivery of miR-29b normalises the dysregulation of bone homeostasis caused by osteosarcoma whilst simultaneously inhibiting tumour growth
Localized nanoparticle-mediated delivery of miR-29b normalises the dysregulation of bone homeostasis caused by osteosarcoma whilst simultaneously inhibiting tumour growth Open
Patients diagnosed with osteosarcoma undergo extensive surgical intervention and chemotherapy resulting in dismal prognosis and compromised quality of life owing to poor bone regeneration, which is further compromised with chemotherapy del…
View article: Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing
Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing Open
Modular biofabrication strategies using microtissues or organoids as biological building blocks have great potential for engineering replacement tissues and organs at scale. Here we describe the development of a biofabrication strategy to …
View article: Scaffold microarchitecture regulates angiogenesis and the regeneration of large bone defects
Scaffold microarchitecture regulates angiogenesis and the regeneration of large bone defects Open
Emerging 3D printing technologies can provide exquisite control over the external shape and internal architecture of scaffolds and tissue engineering (TE) constructs, enabling systematic studies to explore how geometric design features inf…
View article: Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds
Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds Open
Articular cartilage defects fail to heal spontaneously, typically progressing to osteoarthritis. Bone marrow stimulation techniques such as microfracture (MFX) are the current surgical standard of care; however MFX typically produces an in…
View article: Bilayered extracellular matrix derived scaffolds with anisotropic pore architecture guide tissue organization during osteochondral defect repair
Bilayered extracellular matrix derived scaffolds with anisotropic pore architecture guide tissue organization during osteochondral defect repair Open
While some clinical advances in cartilage repair have occurred, osteochondral (OC) defect repair remains a significant challenge, with current scaffold-based approaches failing to recapitulate the complex, hierarchical structure of native …
View article: Affinity-bound growth factor within sulfated interpenetrating network bioinks for bioprinting cartilaginous tissues
Affinity-bound growth factor within sulfated interpenetrating network bioinks for bioprinting cartilaginous tissues Open
3D bioprinting has emerged as a promising technology in the field of tissue engineering and regenerative medicine due to its ability to create anatomically complex tissue substitutes. However, it still remains challenging to develop bioact…
View article: 3D bioprinting of prevascularised implants for the repair of critically-sized bone defects
3D bioprinting of prevascularised implants for the repair of critically-sized bone defects Open
For 3D bioprinted tissues to be scaled-up to clinically relevant sizes, effective prevascularisation strategies are required to provide the necessary nutrients for normal metabolism and to remove associated waste by-products. The aim of th…
View article: 3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration
3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration Open
Spatiotemporal delivery of VEGF and BMP-2 from 3D bioprinted implants enhances angiogenesis and subsequent bone regeneration.
View article: A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect
A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect Open
There is a distinct clinical need for new therapies that provide an effective treatment for large bone defect repair. Herein we describe a developmental approach, whereby constructs are primed to mimic certain aspects of bone formation tha…
View article: Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering
Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering Open
Interconnected porosity is critical to the design of regenerative scaffolds, as it permits cell migration, vascularisation and diffusion of nutrients and regulatory molecules inside the scaffold. 3D printing is a promising strategy to achi…
View article: Tuning Alginate Bioink Stiffness and Composition for Controlled Growth Factor Delivery and to Spatially Direct MSC Fate within Bioprinted Tissues
Tuning Alginate Bioink Stiffness and Composition for Controlled Growth Factor Delivery and to Spatially Direct MSC Fate within Bioprinted Tissues Open
Alginate is a commonly used bioink in 3D bioprinting. Matrix stiffness is a key determinant of mesenchymal stem cell (MSC) differentiation, suggesting that modulation of alginate bioink mechanical properties represents a promising strategy…
View article: 3D Bioprinting for Cartilage and Osteochondral Tissue Engineering
3D Bioprinting for Cartilage and Osteochondral Tissue Engineering Open
Significant progress has been made in the field of cartilage and bone tissue engineering over the last two decades. As a result, there is real promise that strategies to regenerate rather than replace damaged or diseased bones and joints w…
View article: Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template
Osteogenic Differentiation of Mesenchymal Stem Cells by Mimicking the Cellular Niche of the Endochondral Template Open
In vitro bone regeneration strategies that prime mesenchymal stem cells (MSCs) with chondrogenic factors, to mimic aspects of the endochondral ossification process, have been shown to promote mineralization and vascularization by MSCs both…
View article: Chondrogenic and vascular priming: an endochondral ossification approach to bone tissue regeneration
Chondrogenic and vascular priming: an endochondral ossification approach to bone tissue regeneration Open
Tissue engineering and regenerative medicine have significant potential to treat bone pathologies by exploiting the capacity for bone progenitors to grow and produce tissue constituents under specific biochemical and physical conditions. H…