Fiona E. Serack
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View article: Syngeneic adipose-derived stromal cells modulate the immune response but have limited persistence within decellularized adipose tissue implants in C57BL/6 mice
Syngeneic adipose-derived stromal cells modulate the immune response but have limited persistence within decellularized adipose tissue implants in C57BL/6 mice Open
The delivery of adipose-derived stromal cells (ASCs) on cell-instructive decellularized adipose tissue (DAT) scaffolds is a promising strategy for stimulating host-derived soft tissue regeneration. However, a better understanding of the me…
View article: In vivo base editing extends lifespan of a humanized mouse model of prion disease
In vivo base editing extends lifespan of a humanized mouse model of prion disease Open
Prion disease is a fatal neurodegenerative disease caused by the misfolding of prion protein (PrP) encoded by the PRNP gene. While there is currently no cure for the disease, depleting PrP in the brain is an established strategy to prevent…
View article: Divalent siRNA for prion disease
Divalent siRNA for prion disease Open
Pharmacologic lowering of PrP expression is efficacious against prion disease in animal models and is now being tested clinically. 50% lowering of PrP increases both survival time and healthy life in prion-infected mice, but does not preve…
View article: PrP turnover in vivo and the time to effect of prion disease therapeutics
PrP turnover in vivo and the time to effect of prion disease therapeutics Open
PrP lowering is effective against prion disease in animal models and is being tested clinically. Therapies in the current pipeline lower PrP production, leaving pre-existing PrP to be cleared according to its own half-life. We hypothesized…
View article: Syngeneic adipose-derived stromal cells modulate the immune response but have limited persistence within decellularized adipose tissue implants in C57BL/6 mice
Syngeneic adipose-derived stromal cells modulate the immune response but have limited persistence within decellularized adipose tissue implants in C57BL/6 mice Open
The delivery of adipose-derived stromal cells (ASCs) on cell-instructive decellularized adipose tissue (DAT) scaffolds is a promising strategy for stimulating host-derived soft tissue regeneration. However, a better understanding of the me…
View article: Probing the effects of polysaccharide hydrogel composition on the viability and pro‐angiogenic function of human adipose‐derived stromal cells
Probing the effects of polysaccharide hydrogel composition on the viability and pro‐angiogenic function of human adipose‐derived stromal cells Open
Cell therapies harnessing the pro‐vascular regenerative capacities of mesenchymal stromal cell (MSC) populations, including human adipose‐derived stromal cells (hASCs), have generated considerable interest as an emerging treatment strategy…
View article: Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor Open
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts prion disease progression. In this stu…
View article: Probing the effects of polysaccharide hydrogel composition on the viability and pro-angiogenic function of human adipose-derived stromal cells
Probing the effects of polysaccharide hydrogel composition on the viability and pro-angiogenic function of human adipose-derived stromal cells Open
Cell therapies harnessing the pro-vascular regenerative capacities of mesenchymal stromal cell (MSC) populations, including human adipose-derived stromal cells (hASCs), have generated considerable interest as an emerging treatment strategy…
View article: Delivery of human adipose-derived stromal cells within<i>in situ</i>forming chitosan/PEG-PTMC hydrogels induces adverse outcomes in a femoral artery ligation model in athymic<i>nu/nu</i>mice
Delivery of human adipose-derived stromal cells within<i>in situ</i>forming chitosan/PEG-PTMC hydrogels induces adverse outcomes in a femoral artery ligation model in athymic<i>nu/nu</i>mice Open
The delivery of human adipose-derived stromal cells (hASCs) to ischemic tissues represents a promising strategy to promote vascular regeneration for patients with critical limb ischemia (CLI). Building on previous work, this study focused …
View article: RGD-functionalized electrospun scaffold for ACL tissue engineering
RGD-functionalized electrospun scaffold for ACL tissue engineering Open
This thesis describes the preparation and evaluation of a biomimetic scaffold for anterior cruciate ligament (ACL) tissue engineering. An electrospun poly(L-lactide-co¬-acrylated trimethylene carbonate) scaffold was functionalized with a p…