Fiona Murphy
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View article: Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma Open
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Given that neutrophils are known to display a prominent …
View article: Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma Open
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Given that neutrophils are known to display a prominent …
View article: From sixty-four percent hyperparasitemia to recovery: Managing severe falciparum malaria and delayed hemolytic anemia
From sixty-four percent hyperparasitemia to recovery: Managing severe falciparum malaria and delayed hemolytic anemia Open
Severe falciparum malaria requires urgent and aggressive management. While artesunate is life-saving, its delayed complications necessitate systematic monitoring. This case highlights the importance of integrating acute care with vigilant …
View article: Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard
Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard Open
Over the past decade, the development of nanomaterials (NMs) has surged, highlighting their potential benefits across multiple industries. However, concerns regarding human and environmental exposure remain significant. Traditional in vivo…
View article: Non-cyclic nucleotide EPAC1 activators suppress lipopolysaccharide-regulated gene expression, signalling and intracellular communication in differentiated macrophage-like THP-1 cells
Non-cyclic nucleotide EPAC1 activators suppress lipopolysaccharide-regulated gene expression, signalling and intracellular communication in differentiated macrophage-like THP-1 cells Open
This study explores the anti-inflammatory effects of non-cyclic nucleotide EPAC1 activators, PW0577 and SY007, on lipopolysaccharide (LPS)-induced responses in differentiated THP-1 macrophage-like cells. Both activators were found to selec…
View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
Background Neutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. …
View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
BackgroundNeutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. T…
View article: Similarity of multicomponent nanomaterials in a safer-by-design context: the case of core–shell quantum dots
Similarity of multicomponent nanomaterials in a safer-by-design context: the case of core–shell quantum dots Open
Concepts of similarity applied to complex multicomponent advanced materials for an informed balance of performance and hazard.
View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
Background Neutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility.…
View article: Vascular smooth muscle cells enhance immune/vascular interplay in a 3-cell model of vascular inflammation
Vascular smooth muscle cells enhance immune/vascular interplay in a 3-cell model of vascular inflammation Open
Atherosclerosis is a serious cardiovascular disease that is characterised by the development of atheroma, which are lipid-laden plaques that build up within arterial walls due to chronic inflammatory processes. These lesions are fundamenta…
View article: 67 Development of a Physiologically-Relevant in Vitro Model of the Lung, Incorporating Novel Peptide Hydrogels as Biomimetic Extracellular Matrix Scaffolds
67 Development of a Physiologically-Relevant in Vitro Model of the Lung, Incorporating Novel Peptide Hydrogels as Biomimetic Extracellular Matrix Scaffolds Open
The vast number of different nanomaterials (NMs) in production and under development precludes the complete hazard assessment of each individual substance according to current regulatory standards which require long term in vivo studies. T…
View article: 2 Humanising Nanotoxicology Testing: Moving Towards Animal-free Approaches for Hazard Assessment of Nanomaterials
2 Humanising Nanotoxicology Testing: Moving Towards Animal-free Approaches for Hazard Assessment of Nanomaterials Open
The vast array of nanomaterials (NMs) under development raises ethical concerns over the reliance and extent of animal usage in the hazard assessment of substances. Grouping which allows read-across of data from NMs predicted to pose simil…
View article: GRACIOUS - eNanoMapper database
GRACIOUS - eNanoMapper database Open
The GRACIOUS project developed a highly innovative science-based Framework to enable practical application of grouping, leading to read-across and classification of nanomaterials and nanoforms. Since 1 April 2023 the data gathered in the p…
View article: GRACIOUS - eNanoMapper database
GRACIOUS - eNanoMapper database Open
The GRACIOUS project developed a highly innovative science-based Framework to enable practical application of grouping, leading to read-across and classification of nanomaterials and nanoforms. Since 1 April 2023 the data gathered in the p…
View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
BackgroundNeutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. T…
View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
BackgroundNeutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. T…
View article: Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study
Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study Open
Background The EU-project GRACIOUS developed an Integrated Approach to Testing and Assessment (IATA) to support grouping high aspect ratio nanomaterials (HARNs) presenting a similar inhalation hazard. Application of grouping reduces the ne…
View article: Developing Integrated Approaches for Testing and Assessment (IATAs) in order to support nanomaterial safety
Developing Integrated Approaches for Testing and Assessment (IATAs) in order to support nanomaterial safety Open
Due to the unique characteristics of nanomaterials (NM) there has been an increase in their use in nanomedicines and innovative medical devices (MD). Although large numbers of NMs have now been developed, comprehensive safety investigation…
View article: Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence
Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence Open
Acute Respiratory Distress Syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, has no cure. Hypoxemia is a defining feature, yet its impact on inflammation is often neglected. Patients with ARDS are monocyto…