Fiona Harding
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Sequential JAK inhibition enhances antitumor immunity after combined anti–PD-1 and anti-CTLA4 Open
While immune checkpoint inhibition (CPI) has reshaped cancer treatment, the majority of patients with cancer do not benefit from this approach, which can also cause immune-related adverse events. Induction of IFN-γ responses is thought be …
View article: Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint
Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint Open
The aminopeptidase, endoplasmic reticulum aminopeptidase 1 (ERAP1), trims peptides for loading into major histocompatibility complex class I (MHC class I), and loss of this activity has broad effects on the MHC class I peptidome. Here, we …
Identifying predictors of adverse outcomes after termination of seclusion in psychiatric intensive care units Open
Background Seclusion is a restrictive practice that many healthcare services are trying to reduce. Previous studies have sought to identify predictors of seclusion initiation, but few have investigated factors associated with adverse outco…
View article: Interactions between the gut microbiome, dietary restriction, and aging in genetically diverse mice
Interactions between the gut microbiome, dietary restriction, and aging in genetically diverse mice Open
Summary The intestinal microbiome changes with age, but the causes and consequences of microbiome aging remain unclear. Furthermore, the gut microbiome has been proposed to mediate the benefit of lifespan- extending interventions such as d…
View article: 1143 cDC1 engagement induces Th1 differentiation and tumor regression in vivo
1143 cDC1 engagement induces Th1 differentiation and tumor regression in vivo Open
Background Dendtritic cell (DC) vaccine therapies have so far demonstrated limited success as cancer therapeutics. Recently, cDC1 have been shown to support CD8 and CD4 activation, and both cell types were necessary for anti-tumor response…
1034 Identification of a potentially novel regulatory axis involving KIR+CD8+ HLA-E/VL9 tetramer+ T cells and HLA-E<sup>hi</sup> cTFH Open
Background T follicular helper cells (TFH) within the tumor microenvironment are associated with good prognosis, and inhibition of regulatory Ly49+CD8 T cells in mice enhances anti-tumor activity via expansion of TFH responses.1 We investi…
A Quality Improvement Project Reviewing the Quality of Information Included in Discharge Summaries Sent to General Practitioners (GPs) From a Home Treatment Team (HTT) in an Inner London Borough Open
Aims To improve the quality of the information included in discharge summaries to GPs from HTT. To gather the views of local GPs as to what constitutes a good discharge summary. To streamline the process for creating the discharge summarie…
Novel <span>PE</span> and <span>APC</span> tandems: Additional <span>near‐infrared</span> fluorochromes for use in spectral flow cytometry Open
Recent advances in flow cytometry instrumentation and fluorochrome chemistries have greatly increased fluorescent conjugated antibody combinations that can be used reliably and easily in routine experiments. The Cytek Aurora flow cytometer…
Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma Open
Children with B-cell non-Hodgkin lymphoma (B-NHL) have an excellent chance of survival, however, current clinical risk stratification places as many as half of patients in a high-risk group receiving very intensive chemo-immunotherapy. TP5…
View article: Perspectives on psychedelic treatment and research in eating disorders: a web-based questionnaire study of people with eating disorders
Perspectives on psychedelic treatment and research in eating disorders: a web-based questionnaire study of people with eating disorders Open
Approximately 1.25 million people in the UK suffer from an eating disorder, yet the treatment options show limited efficacy, warranting the need for novel approaches. This study aimed to investigate the perspectives of people with eating d…
Novel PE and APC Tandems: Additional Near-Infrared Fluorochromes for Use in Spectral Flow Cytometry Open
Recent advances in flow cytometry instrumentation and fluorochrome chemistries have greatly increased fluorescent conjugated antibody combinations that can be used reliably and easily in routine experiments. The Cytek Aurora flow cytometer…