Fiona K B Buchanan
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View article: Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of<i>Cdkl5</i>deficiency
Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of<i>Cdkl5</i>deficiency Open
Many neurodevelopmental disorders (NDDs) are the result of mutations on the X chromosome. One severe NDD resulting from mutations on the X chromosome is CDKL5 deficiency disorder (CDD). CDD is an epigenetic, X-linked NDD characterized by i…
View article: An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models
An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models Open
Zinc finger (ZF), transcription activator-like effectors (TALE), and CRISPR/Cas9 therapies to regulate gene expression are becoming viable strategies to treat genetic disorders, although effective in vivo delivery systems for these protein…
View article: Artificial escape from XCI by DNA methylation editing of the CDKL5 gene
Artificial escape from XCI by DNA methylation editing of the CDKL5 gene Open
A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter…