Fiona Mack
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View article: Predicting <i>In Vivo</i> Efficacy from <i>In Vitro</i> Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer
Predicting <i>In Vivo</i> Efficacy from <i>In Vitro</i> Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer Open
Reliably predicting in vivo efficacy from in vitro data would facilitate drug development by reducing animal usage and guiding drug dosing in human clinical trials. However, such prediction remains challenging. Here, we built a quantitativ…
View article: Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition Open
Epigenetic therapy may induce tumor-suppressive Notch signaling in patients with small cell lung cancer.