Fiona Moultrie
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View article: Genotypic, functional, and phenotypic characterization in CTNNB1 neurodevelopmental syndrome
Genotypic, functional, and phenotypic characterization in CTNNB1 neurodevelopmental syndrome Open
View article: Pushing the boundaries: future directions in the management of spinal muscular atrophy
Pushing the boundaries: future directions in the management of spinal muscular atrophy Open
View article: Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review.
Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review. Open
The purpose of this scoping review is to assess the risks and benefits of providing analgesic and sedative drugs to ventilated premature infants. We sourced primary empirical research reporting outcomes related to the use of pharmacologica…
View article: Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK
Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK Open
View article: Parental experience of neonatal pain research while participating in the Parental touch trial (Petal)
Parental experience of neonatal pain research while participating in the Parental touch trial (Petal) Open
Parental involvement in neonatal comfort care is a core component of family-centred care. Yet, parents experience a range of positive and negative feelings when providing pain-relieving interventions for their infants. Parents of infants w…
View article: High-resolution diffusion imaging in the unfixed post-mortem infant brain at 7 T
High-resolution diffusion imaging in the unfixed post-mortem infant brain at 7 T Open
Diffusion MRI of the infant brain allows investigation of the organizational structure of maturing fibers during brain development. Post-mortem imaging has the potential to achieve high resolution by using long scan times, enabling precise…
View article: Multicentre, randomised controlled trial to investigate the effects of parental touch on relieving acute procedural pain in neonates (Petal)
Multicentre, randomised controlled trial to investigate the effects of parental touch on relieving acute procedural pain in neonates (Petal) Open
Introduction Newborn infants routinely undergo minor painful procedures as part of postnatal care, with infants born sick or premature requiring a greater number of procedures. As pain in early life can have long-term neurodevelopmental co…
View article: The impact of premature extrauterine exposure on infants’ stimulus-evoked brain activity across multiple sensory systems
The impact of premature extrauterine exposure on infants’ stimulus-evoked brain activity across multiple sensory systems Open
Prematurity can result in widespread neurodevelopmental impairment, with the impact of premature extrauterine exposure on brain function detectable in infancy. A range of neurodynamic and haemodynamic functional brain measures have previou…
View article: The impact of premature extrauterine exposure on infants’ stimulus-evoked brain activity across multiple sensory systems
The impact of premature extrauterine exposure on infants’ stimulus-evoked brain activity across multiple sensory systems Open
Prematurity can result in widespread neurodevelopmental impairment, with the impact of premature extrauterine exposure on brain function detectable in infancy. A range of neurodynamic and haemodynamic functional brain measures have previou…
View article: Functional and diffusion MRI reveal the neurophysiological basis of neonates’ noxious-stimulus evoked brain activity
Functional and diffusion MRI reveal the neurophysiological basis of neonates’ noxious-stimulus evoked brain activity Open
Understanding the neurophysiology underlying neonatal responses to noxious stimulation is central to improving early life pain management. In this neonatal multimodal MRI study, we use resting-state and diffusion MRI to investigate inter-i…
View article: The Forget-Me-Not dHCP study: 7 Tesla high resolution diffusion imaging in the unfixed post-mortem neonatal brain
The Forget-Me-Not dHCP study: 7 Tesla high resolution diffusion imaging in the unfixed post-mortem neonatal brain Open
Diffusion MRI of the neonatal brain allows investigation of the organisational structure of maturing fibres during brain development. Post-mortem imaging has the potential to achieve high resolution by using long scan times, enabling preci…
View article: Functional and diffusion MRI reveal the neurophysiological basis of neonates’ noxious-stimulus evoked brain activity
Functional and diffusion MRI reveal the neurophysiological basis of neonates’ noxious-stimulus evoked brain activity Open
View article: Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials
Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials Open
Despite the high burden of pain experienced by hospitalised neonates, there are few analgesics with proven efficacy. Testing analgesics in neonates is experimentally and ethically challenging and minimising the number of neonates required …
View article: Functional and diffusion MRI reveal the neurophysiological basis of neonates’ noxious-stimulus evoked brain activity
Functional and diffusion MRI reveal the neurophysiological basis of neonates’ noxious-stimulus evoked brain activity Open
Understanding the neurophysiology underlying neonatal responses to noxious stimulation is central to improving early life pain management. In this neonatal multimodal MRI study, we use resting-state and diffusion MRI to investigate inter-i…
View article: Author response: Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials
Author response: Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Despite the high burden of pa…
View article: Functional and diffusion MRI reveal the functional and structural basis of infants’ noxious-evoked brain activity
Functional and diffusion MRI reveal the functional and structural basis of infants’ noxious-evoked brain activity Open
Understanding the neurophysiology underlying neonatal responses to noxious stimulation is central to improving early life pain management. In this neonatal multimodal MRI study, we use resting-state and diffusion MRI to investigate inter-i…
View article: Quantifying individual nociceptive sensitivity to optimise analgesic trials in infants
Quantifying individual nociceptive sensitivity to optimise analgesic trials in infants Open
Despite the high burden of pain experienced by hospitalised infants there are few analgesics with proven efficacy. Testing analgesics in infants is experimentally and ethically challenging and minimising the number of infants required to d…
View article: Predicting severity of adverse cardiorespiratory effects of morphine in premature infants: a post hoc analysis of Procedural Pain in Premature Infants trial data
Predicting severity of adverse cardiorespiratory effects of morphine in premature infants: a post hoc analysis of Procedural Pain in Premature Infants trial data Open
Editor—Hospitalised infants can experience pain during essential clinical procedures. However, pharmacological analgesics are infrequently prescribed, often out of fear of adverse effects.1Hartling L. Ali S. Dryden D.M. et al.How safe are …
View article: Inferring pain experience in infants using quantitative whole-brain functional MRI signatures: a cross-sectional, observational study
Inferring pain experience in infants using quantitative whole-brain functional MRI signatures: a cross-sectional, observational study Open
View article: Functional and diffusion MRI reveal the functional and structural basis of infants’ noxious-evoked brain activity
Functional and diffusion MRI reveal the functional and structural basis of infants’ noxious-evoked brain activity Open
Understanding the neurophysiology underlying pain perception in infants is central to improving early life pain management. In this multimodal MRI study, we use resting-state functional and white matter diffusion MRI to investigate individ…
View article: Functional and diffusion MRI reveal the functional and structural basis of infants’ noxious-evoked brain activity
Functional and diffusion MRI reveal the functional and structural basis of infants’ noxious-evoked brain activity Open
Understanding the neurophysiology underlying pain perception in infants is central to improving early life pain management. In this multimodal MRI study, we use resting-state functional and white matter diffusion MRI to investigate individ…
View article: Inferring the Infant Pain Experience: A Translational fMRI-Based Signature Study
Inferring the Infant Pain Experience: A Translational fMRI-Based Signature Study Open
View article: Oral morphine analgesia for preventing pain during invasive procedures in non-ventilated premature infants in hospital: the Poppi RCT
Oral morphine analgesia for preventing pain during invasive procedures in non-ventilated premature infants in hospital: the Poppi RCT Open
Background Identifying better pain management strategies for painful procedures performed in neonatal care is a clinical priority. Retinopathy of prematurity screening and heel-lance blood tests are essential clinical procedures, but adequ…
View article: Setting up a stopping boundary for safety in a phase II trial: the Poppi trial
Setting up a stopping boundary for safety in a phase II trial: the Poppi trial Open
View article: A universal right to pain relief: balancing the risks in a vulnerable patient population
A universal right to pain relief: balancing the risks in a vulnerable patient population Open
View article: Stroking modulates noxious-evoked brain activity in human infants
Stroking modulates noxious-evoked brain activity in human infants Open
A subclass of C fibre sensory neurons found in hairy skin are activated by gentle touch [1] and respond optimally to stroking at ∼1-10 cm/s, serving a protective function by promoting affiliative behaviours. In adult humans, stimulation of…
View article: Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial
Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial Open
Wellcome Trust and National Institute for Health Research.
View article: Behavioural discrimination of noxious stimuli in infants is dependent on brain maturation
Behavioural discrimination of noxious stimuli in infants is dependent on brain maturation Open
Changes in facial expression are an essential form of social communication and in nonverbal infants are often used to alert care providers to pain-related distress. However, studies of early human brain development suggest that premature i…
View article: Optimising neonatal fMRI data analysis: Design and validation of an extended dHCP preprocessing pipeline to characterise noxious-evoked brain activity in infants
Optimising neonatal fMRI data analysis: Design and validation of an extended dHCP preprocessing pipeline to characterise noxious-evoked brain activity in infants Open
View article: The influence of the descending pain modulatory system on infant pain-related brain activity
The influence of the descending pain modulatory system on infant pain-related brain activity Open
The descending pain modulatory system (DPMS) constitutes a network of widely distributed brain regions whose integrated function is essential for effective modulation of sensory input to the central nervous system and behavioural responses…