Explanipedia

Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis Open

Maxime Bigotte, Adam M.R. Groh, Elia Afanasiev, Vincent Kam Wai Wong, Moein Yaqubi , et al. · 2025

Multiple sclerosis is a disorder of the central nervous system (CNS) in which autoreactive immune cells migrate through a damaged blood brain barrier, resulting in focal demyelinating lesions. Beyond focal lesions, there are also diffuse s…

Mannose Receptor C type 2 influences autoimmune neuroinflammation and blood-brain barrier integrity Open

Bettina Zierfuss, Melanie Käch, Camille Sugère, Marion Morvan, Haritha L. Desu , et al. · 2025

Relapses in Multiple Sclerosis (MS) are driven by pathogenic immune cells breaching the disrupted blood–brain barrier (BBB), leading to tissue damage and eventual disease progression^1–3. Among the most effective therapies are th…

Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis pathophysiology Open

Maxime Bigotte, Adam M.R. Groh, Elia Afanasiev, Vincent Kam Wai Wong, Kevin Lançon , et al. · 2025

Background Multiple sclerosis is a neurodegenerative autoimmune disorder of the central nervous system (CNS) in which autoreactive immune cells migrate through a damaged blood brain barrier, resulting in focal demyelinating lesions of both…

Peripheral HLA-DR hi CD141 + Classical Monocytes Predict Relapse Risk and Worsening in Multiple Sclerosis Open

Karine Thai, Rose‐Marie Rébillard, Wendy Klément, Omar Ayoub, Olivier Tastet , et al. · 2025

Our findings suggest that the frequency of HLA-DR^hiCD141⁺ CMs could serve as a valuable predictor of disease activity complementary to current clinical tools to guide evidence-based treatment decisions.

Correction: Multiciliated ependymal cells: an update on biology and pathology in the adult brain Open

Adam M.R. Groh, Yeji Lori Song, Fiona Tea, Brianna Lu, Stephanie Huynh , et al. · 2024

A scoping review assessing the usability of digital health technologies targeting people with multiple sclerosis Open

Fiona Tea, Adam M.R. Groh, Colleen Lacey, Afolasade Fakolade · 2024

Digital health technologies (DHTs) have become progressively more integrated into the healthcare of people with multiple sclerosis (MS). To ensure that DHTs meet end-users’ needs, it is essential to assess their usability. The objective of…

The MOG antibody non-P42 epitope is predictive of a relapsing course in MOG antibody-associated disease Open

Ganesha Liyanage, Benjamin Trewin, Joseph A. Lopez, Jane Andersen, Fiona Tea , et al. · 2024

Background Myelin oligodendrocyte glycoprotein (MOG) IgG seropositivity is a prerequisite for MOG antibody-associated disease (MOGAD) diagnosis. While a significant proportion of patients experience a relapsing disease, there is currently …

Infection and Vaccine Induced Spike Antibody Responses Against SARS-CoV-2 Variants of Concern in COVID-19-Naïve Children and Adults Open

Aleha Pillay, Avani Yeola, Fiona Tea, Martina Denkova, Samuel K. Houston , et al. · 2023

Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19 Open

Weng Hua Khoo, Katherine Jackson, Chansavath Phetsouphanh, John Zaunders, José Alquicira-Hernández , et al. · 2022

Infection and vaccine induced Spike antibody responses against SARS-CoV-2 Variants of concern in immune naïve children and adults Open

Aleha Pillay, Avani Yeola, Fiona Tea, Martina Denkova, Samuel K. Houston , et al. · 2022

A more efficient and effective adaptive humoral immune response has been proposed as the basis of the usually favourable outcome of paediatric COVID-19. The breadth of virus and vaccine immunogenicity towards the ever-mutating Spike protei…

Single-Cell Transcriptomics Identifies Brain Endothelium Inflammatory Networks in Experimental Autoimmune Encephalomyelitis Open

Antoine Fournier, Olivier Tastet, Marc Charabati, Chloé Hoornaert, Lyne Bourbonnière , et al. · 2022

In this study, we provide a landscape of the cellular heterogeneity associated with neuroinflammation. We also present important molecular insights for further exploration of specific cell processes that promote infiltration of immune cell…

MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes Open

Marc Charabati, Stéphanie Zandee, Antoine Fournier, Olivier Tastet, Karine Thai , et al. · 2022

The trafficking of autoreactive leucocytes across the blood–brain barrier endothelium is a hallmark of multiple sclerosis pathogenesis. Although the blood–brain barrier endothelium represents one of the main CNS borders to interact with th…

CLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple Sclerosis Open

Antoine Fournier, Stéphanie Zandee, Marc Charabati, Evelyn Peelen, Olivier Tastet , et al. · 2022

Collectively, our data demonstrate that CLMP is an adhesion molecule used by immune cells to access the CNS during neuroinflammatory disorders such as MS. CLMP could represent a target for a new treatment of neuroinflammatory conditions.

2432 Spike antibody seroconversion and breadth following SARS-CoV-2 vaccination in Australian people with Multiple Sclerosis Open

Aleha Pillay, Avani Yeola, Samuel K. Houston, Vicki E. Maltby, Marzena Pedrini , et al. · 2022

Background COVID-19 vaccination induces protective spike antibodies. Some responses are attenuated in people living with multiple sclerosis (MS) on high efficacy disease modifying therapies (DMT). It is unknown whether antibodies afford im…

PB2087: EFFICACY OF A 3RD COVID VACCINE, INCLUDING DURING A BTKI PAUSE, IN INDIVIDUALS WITH WALDENSTRÖM MACROGLOBULINEMIA AND FOLLICULAR LYMPHOMA Open

K. Rankin, Brendan Beaton, Sarah C. Sasson, Joke De Raedemaecker, Angelina Wong , et al. · 2022

Background: Patients (pts) with indolent lymphomas are at increased risk of severe COVID-19 infection. We have shown limited seroconversion and live viral neutralisation (VN), but preserved COVID-specific T cell responses after 2 doses of …

Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti‐spike neutralizing IgG to SARS‐CoV‐2 variants, but preserved antigen‐specific T cell responses Open

Brendan Beaton, Sarah C. Sasson, Katherine Rankin, Juliette Raedemaeker, Alexander Wong , et al. · 2022

Patients with indolent lymphoma undertaking recurrent or continuous B cell suppression are at risk of severe COVID‐19. Patients and healthy controls (HC; N = 13) received two doses of BNT162b2: follicular lymphoma (FL; N = 35) who were tre…

Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19 Open

Weng Hua Khoo, Katherine Jackson, Chansavath Phetsouphanh, John Zaunders, José Alquicira-Hernández , et al. · 2022

SUMMARY Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infec…

Single-Cell Transcriptomics Identifies Brain Endothelium Inflammatory Networks in Experimental Autoimmune Encephalomyelitis Open

Antoine Fournier, Olivier Tastet, Marc Charabati, Chloé Hoornaert, Lyne Bourbonière , et al. · 2022

Validation of a Flow Cytometry Live Cell-Based Assay to Detect Myelin Oligodendrocyte Glycoprotein Antibodies for Clinical Diagnostics Open

Joseph A. Lopez, Samuel D Houston, Fiona Tea, Vera Merheb, Fiona X. Z. Lee , et al. · 2021

Background Myelin oligodendrocyte glycoprotein antibodies (MOG Ab) are essential in the diagnosis of MOG Ab–associated disease (MOGAD). Live cell-based assays (CBAs) are the gold standard for MOG Ab detection with improved sensitivity and …

SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants Open

Fiona Tea, Alberto Ospina Stella, Anupriya Aggarwal, D.R. Darley, Deepti Pilli , et al. · 2021

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants and variant of concern (VOC) are unknown, but critical to understand reinfection risk and breakthr…

Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection Open

Arunasingam Abayasingam, Harikrishnan Balachandran, David Agapiou, Mohamed Hammoud, Chaturaka Rodrigo , et al. · 2021

Considerable concerns relating to the duration of protective immunity against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) exist, with evidence of antibody titers declining rapidly after infection and reports of reinfection…

SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants Open

Fiona Tea, Alberto Ospina Stella, Anupriya Aggarwal, D.R. Darley, Deepti Pilli , et al. · 2020

The SARS-CoV-2 antibody neutralization response and its evasion by emerging viral variants are unknown. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, and infectious …

Long-term persistence of neutralizing memory B cells in SARS-CoV-2 Open

Rowena A. Bull, Arunasingam Abayasingam, Harikrishnan Balachandran, David Agapiou, Chaturaka Rodrigo , et al. · 2020

Considerable concerns relating to the duration of protective immunity against SARS-CoV-2 have been raised, with evidence of antibody titres declining rapidly after infection and reports of reinfection. Here we monitored antibody responses …

Effects of the Positive Threshold and Data Analysis on Human MOG Antibody Detection by Live Flow Cytometry Open

Fiona Tea, Deepti Pilli, Sudarshini Ramanathan, Joseph A. Lopez, Vera Merheb , et al. · 2020

Human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have become a useful clinical biomarker for the diagnosis of a spectrum of inflammatory demyelinating disorders. Live cell-based assays that detect MOG Ab against …

International multicenter examination of MOG antibody assays Open

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan , et al. · 2020

Live MOG-IgG CBAs showed excellent agreement for high positive and negative samples at 3 international testing centers. Low positive samples were more frequently discordant than in a similar comparison of aquaporin-4 antibody assays. Furth…

Pro‐inflammatory dopamine‐2 receptor‐specific T cells in paediatric movement and psychiatric disorders Open

Deepti Pilli, Alicia Zou, Ruebena Dawes, Joseph A. Lopez, Fiona Tea , et al. · 2020

Objectives A dysregulated inflammatory response against the dopamine‐2 receptor (D2R) has been implicated in movement and psychiatric disorders. D2R antibodies were previously reported in a subset of these patients; however, the role of T …

International multicenter examination of MOG antibody assays (vol 7, e674, 2020) Open

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan , et al. · 2020

Long-Term Persistence of Neutralizing Memory B Cells in SARS-CoV-2 Open

Arunasingam Abayasingam, Harikrishnan Balachandran, David Agapiou, Chaturaka Rodrigo, Elizabeth Keoshkerian , et al. · 2020

An international multicenter examination of MOG antibody assays Open

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan , et al. · 2019

Objectives To compare the reproducibility of 11 antibody assays for IgG and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG, MOG-IgM) from five international centers. Methods The following samples were analyzed: MOG-IgG clearly…

Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination Open

Fiona Tea, Joseph A. Lopez, Sudarshini Ramanathan, Vera Merheb, Fiona X. Z. Lee , et al. · 2019

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