Firoj Hassan
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View article: Quantum chemical modeling, molecular docking, and ADMET evaluation of imidazole phenothiazine hybrids
Quantum chemical modeling, molecular docking, and ADMET evaluation of imidazole phenothiazine hybrids Open
View article: Synthesis, Characterization and Computational Studies Of (Z)-3-((5-Chloropyridin-2-Yl) Imino)-1-(Oxiran-2-Ylmethyl) Indolin-2-One
Synthesis, Characterization and Computational Studies Of (Z)-3-((5-Chloropyridin-2-Yl) Imino)-1-(Oxiran-2-Ylmethyl) Indolin-2-One Open
Heterocyclic scaffolds, particularly those derived from isatin, have arisen as promising choices for the generation of new druglike candidates because of their structural flexibility and potent biological activity. This study describes the…
View article: Epoxy-Functionalized Isatin Derivative: Synthesis, Computational Evaluation, and Antibacterial Analysis
Epoxy-Functionalized Isatin Derivative: Synthesis, Computational Evaluation, and Antibacterial Analysis Open
Background/Objectives: The current need for new antibacterial compounds that target non-classical pathways is highlighted by the emergence of multidrug-resistant Klebsiella pneumoniae. In the development of antibiotics, DNA adenine methylt…
View article: Importance of Synthesized Chalcone‐Functionality for Derivatization and Their Biological Activity
Importance of Synthesized Chalcone‐Functionality for Derivatization and Their Biological Activity Open
In the context of literature reports, here is a summary of the different strategies that were used for the formation of α,β‐unsaturated carbonyl functionality and their biological properties. However, as per previous work on chalcone, it w…
View article: Exploration of novel azole-quinoline hybrids as LdNMT inhibitors using in-silico approach; molecular docking, DFT, molecular dynamics simulations, MMGBSA and ADMET
Exploration of novel azole-quinoline hybrids as LdNMT inhibitors using in-silico approach; molecular docking, DFT, molecular dynamics simulations, MMGBSA and ADMET Open
Leishmania donovani, the causative agent of visceral leishmaniasis (VL), is prevalent in Brazil, East Africa, and India. The treatment options for VL are currently limited and are often associated with adverse effects, highlighting the urg…
View article: Artificial Intelligence in Computer-Aided Drug Design (CADD) Tools for the Finding of Potent Biologically Active Small Molecules
Artificial Intelligence in Computer-Aided Drug Design (CADD) Tools for the Finding of Potent Biologically Active Small Molecules Open
View article: Drug repositioning to discover novel ornithine decarboxylase inhibitors against visceral leishmaniasis
Drug repositioning to discover novel ornithine decarboxylase inhibitors against visceral leishmaniasis Open
Visceral leishmaniasis (VL) is caused by Leishmania donovani ( Ld ), and most cases occur in Brazil, East Africa, and India. The treatment for VL is limited and has many adverse effects. The development of safer and more efficacious drugs …
View article: Drug Repurposing against Phosphomannomutase for the Treatment of Cutaneous Leishmaniasis
Drug Repurposing against Phosphomannomutase for the Treatment of Cutaneous Leishmaniasis Open
Due to the lack of approved vaccines against Cutaneous leishmaniasis (CL), chemotherapy is the only treatment option. Presently, none of the current CL drugs have high levels of efficacy and safety profiles. Thus, the development of new an…
View article: Drug Repurposing and High-throughput screening against Phosphomannomutase for the treatment of Cutaneous Leishmaniasis
Drug Repurposing and High-throughput screening against Phosphomannomutase for the treatment of Cutaneous Leishmaniasis Open
Cutaneous leishmaniasis (CL) is caused by the protozoan parasite L. maxicana is one of the major parasitic diseases throughout the world. Due to the lack of approved vaccines against CL, chemotherapy is the only modern treatment. These tre…
View article: A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles
A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles Open
Nitrogen containing heterocyclic compounds are biologically significant molecules. This is especially true for pyrrole a five membered nitrogen containing aromatic molecule, which is present as a key structural motif in a large number of d…
View article: Synthesis, Characterization and Physicochemical Analysis of some Mannofuranoside Derivatives with Potent Antimicrobial Activity
Synthesis, Characterization and Physicochemical Analysis of some Mannofuranoside Derivatives with Potent Antimicrobial Activity Open
Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It prov…