Flávia C. Leonardo
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View article: Caspase-1 activation drives vascular inflammatory processes and hypoperfusion in intravascular hemolysis
Caspase-1 activation drives vascular inflammatory processes and hypoperfusion in intravascular hemolysis Open
This study identifies caspase-1 as a driver of the microvascular leukocyte recruitment and hypoperfusion that is induced by intravascular hemolysis (IVH). Using in vivo models and heme-stimulated endothelial cells, we show that IVH rapidly…
View article: Hydroxyurea Improves Mesenteric Blood Flow and Reduces Gut Permeability in Sickle Cell Disease Mice
Hydroxyurea Improves Mesenteric Blood Flow and Reduces Gut Permeability in Sickle Cell Disease Mice Open
View article: Caspase-Driven Microvascular Inflammation and Hypoperfusion in Intravascular Hemolysis: Roles of Leukocyte and Endothelial Activation
Caspase-Driven Microvascular Inflammation and Hypoperfusion in Intravascular Hemolysis: Roles of Leukocyte and Endothelial Activation Open
Intravascular hemolysis (IVH), a pathological process associated with various conditions, triggers vascular responses; however, the molecular and cellular mechanisms driving this process remain unclear. To explore the role of NLRP3 inflamm…
View article: Acute intravascular haemolysis rapidly shifts the balance of angiogenic factors and accelerates neovascularization in vivo
Acute intravascular haemolysis rapidly shifts the balance of angiogenic factors and accelerates neovascularization in vivo Open
View article: Targeting P-selectin and interleukin-1β in mice with sickle cell disease: effects on vaso-occlusion, liver injury and organ iron deposition
Targeting P-selectin and interleukin-1β in mice with sickle cell disease: effects on vaso-occlusion, liver injury and organ iron deposition Open
Continuous vaso-occlusive and inflammatory processes cause extensive end-organ damage in adults with sickle cell disease (SCD), and there is little evidence that longterm hydroxyurea therapy prevents this. In initial trials, P-selectin blo…
View article: S266: DIFFERENT MOLECULAR VASO-OCCLUSIVE TRIGGERS STIMULATE DISTINCT VASO-OCCLUSIVE PROFILES: IN VIVO RESULTS FROM MICE WITH SICKLE CELL ANEMIA
S266: DIFFERENT MOLECULAR VASO-OCCLUSIVE TRIGGERS STIMULATE DISTINCT VASO-OCCLUSIVE PROFILES: IN VIVO RESULTS FROM MICE WITH SICKLE CELL ANEMIA Open
Background: Microvascular vaso-occlusion (VO) characterizes sickle cell anemia (SCA) pathophysiology and is the result of inflammatory mechanisms that promote interactions of leukocytes and erythrocytes with the endothelium, with consequen…
View article: P-036: PIEZO1 ACTIVATION AUGMENTS SICKLING PROPENSITY AND THE ADHESIVE PROPERTIES OF SICKLE RED BLOOD CELLS
P-036: PIEZO1 ACTIVATION AUGMENTS SICKLING PROPENSITY AND THE ADHESIVE PROPERTIES OF SICKLE RED BLOOD CELLS Open
Purpose: Sickle cell disease (SCD) alters the hemoglobin molecule, modifying the properties of red blood cells (RBC) and causing their destruction in the circulation, leading to multiple complications. The increased adhesive properties and…
View article: TGF-β1 Reduces Neutrophil Adhesion and Prevents Acute Vaso-Occlusive Processes in Sickle Cell Disease Mice
TGF-β1 Reduces Neutrophil Adhesion and Prevents Acute Vaso-Occlusive Processes in Sickle Cell Disease Mice Open
Sickle cell disease (SCD) patients experience chronic inflammation and recurrent vaso-occlusive episodes during their entire lifetime. Inflammation in SCD occurs with the overexpression of several inflammatory mediators, including transfor…
View article: Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition
Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition Open
Background Sickle cell disease (SCD) incurs vaso-occlusive episodes and organ damage, including nephropathy. Despite displaying characteristics of vascular dysfunction, SCD patients tend to present relatively lower systemic blood pressure …
View article: Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies
Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies Open
View article: Comparação do Perfil Hemolitíco e Inflamatório em Doenças Hemolitícas.
Comparação do Perfil Hemolitíco e Inflamatório em Doenças Hemolitícas. Open
Nas anemias hemolíticas, um grupo de doenças em que a sobrevida do eritrócito na circulação é reduzida, pode ocorrer a liberação da hemoglobina (Hb) no plasma.Doenças como Anemia Falciforme (AF), Esferocitose Hereditária (EH) e Hemoglobinú…
View article: Expanding the Knowledge on Lignocellulolytic and Redox Enzymes of Worker and Soldier Castes from the Lower Termite Coptotermes gestroi
Expanding the Knowledge on Lignocellulolytic and Redox Enzymes of Worker and Soldier Castes from the Lower Termite Coptotermes gestroi Open
Termites are considered one of the most efficient decomposers of lignocelluloses on Earth due to their ability to produce, along with its microbial symbionts, a repertoire of carbohydrate-active enzymes (CAZymes). Recently, a set of Pro-ox…
View article: Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea
Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea Open
Key Points Hemolytic processes induce rapid systemic and vascular inflammation in C57BL/6 mice that is abolished by a single dose of hydroxyurea (HU). HU exerts some NO-dependent effects and should be investigated as an acute treatment of …
View article: Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea
Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea Open
As hypoxia-induced inflammatory angiogenesis may contribute to the manifestations of sickle cell disease, we compared the angiogenic molecular profiles of plasma from sickle cell disease individuals and correlated these with in vitro endot…