Flávia E. Rius
YOU?
Author Swipe
View article: A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians Using Exome Sequencing
A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians Using Exome Sequencing Open
Background/Objectives: Brazil has a highly admixed population. Polygenic risk scores (PRSs) have mostly been developed from European population studies, and their application to other populations is challenging. To assess the use of PRS fo…
View article: A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians using Exome Sequencing
A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians using Exome Sequencing Open
Background Brazil has a highly admixed population. Polygenic Risk Scores (PRS) have mostly been developed from European population studies, and their application to other populations is challenging. To assess the use of PRS for breast canc…
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival Open
The epigenetic changes associated with melanoma progression to advanced and metastatic stages are still poorly understood. To shed light on the CpG methylation dynamics during melanoma development, we analyzed the methylome profiles of a f…
Genes regulated by DNA methylation are involved in distinct phenotypes during melanoma progression and are prognostic factors for patients Open
In addition to mutations, epigenetic alterations are important contributors to malignant transformation and tumor progression. The aim of this work was to identify epigenetic events in which promoter or gene body DNA methylation induces ge…
View article: Additional file 6 of Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival
Additional file 6 of Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival Open
Additional file 6: Table S6. Equivalence list between mouse ERRBS CpGs location and human Infinium 450 k CpGs probes and location referenced by their closest gene.
Additional file 1 of Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival Open
Additional file 1: Table S1. Complete list of differentially methylated CpGs with the respective genes for each pairwise comparison.
Additional file 4 of Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival Open
Additional file 4: Table S4. Cox proportional-hazards models of significant hypermethylated and hypomethylated CpGs individually from malignancy and metastasis signatures.
Additional file 3 of Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival Open
Additional file 3: Table S3. Characteristics of the melanoma patients from TCGA-SKCM selected for the Cox proportional-hazards models.
Additional file 2 of Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival Open
Additional file 2: Table S2. Genes with differentially methylated promoters in the malignancy and metastasis signatures.
Additional file 5 of Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival Open
Additional file 5: Table S5. Complete list of covariates included in the final Cox survival model for malignancy and metastasis signatures with their respective metrics.
Gene expression and promoter methylation of angiogenic and lymphangiogenic factors as prognostic markers in melanoma Open
The high mortality rate of melanoma is broadly associated with its metastatic potential. Tumor cell dissemination is strictly dependent on vascularization; therefore, angiogenesis and lymphangiogenesis play an essential role in metastasis.…