Flavia Marzetta
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View article: Comprehensive characterization of early-stage Non-Small Cell Lung cancers with multi-modal data integration
Comprehensive characterization of early-stage Non-Small Cell Lung cancers with multi-modal data integration Open
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related death despite the availability of therapies targeting the tumor microenvironment (TME) and/or the tumor. Immunotherapy and novel targeted therapy have improv…
View article: Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial
Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial Open
We recently indicated that four-week probiotic supplementation significantly reduced depression along with microbial and neural changes in people with depression. Here we further elucidated the biological modes of action underlying the ben…
View article: Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial
Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial Open
We recently indicated that four-week probiotic supplementation significantly reduced depression along with microbial and neural changes in people with depression. Here we further elucidated the biological modes of action underlying the ben…
View article: Correction to: Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia
Correction to: Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia Open
View article: 176P Multiplex-immunoflourescence spatial patterns to predict triple-negative breast cancer molecular subtypes in the IMMUcan study
176P Multiplex-immunoflourescence spatial patterns to predict triple-negative breast cancer molecular subtypes in the IMMUcan study Open
IMMUcan (SPECTA NCT02834884) is a European initiative to profile the tumor microenvironment (TME) for a better understanding of immune-tumor interactions. Here, we explored the association between distinct molecular phenotypes and spatial …
View article: 1P Integrated data analysis within IMMUcan identifies prognostic features of early NSCLC
1P Integrated data analysis within IMMUcan identifies prognostic features of early NSCLC Open
The advent of personalized medicine and ever-increasing numbers of available cancer drugs necessitate better prognostic and predictive biomarkers. In turn, this requires a deeper profiling and understanding of tumors and the tumor microenv…
View article: 179P Integrating multiplex immunofluorescence with gene expression data in the IMMUcan HER2-positive breast cancer cohort
179P Integrating multiplex immunofluorescence with gene expression data in the IMMUcan HER2-positive breast cancer cohort Open
View article: Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia
Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia Open
View article: 2266P IMMUcan consortium: Focus on the first results of the non-small cell lung cancer (NSCLC) cohort
2266P IMMUcan consortium: Focus on the first results of the non-small cell lung cancer (NSCLC) cohort Open
View article: Identification of a unique transcriptomic signature associated with islet amyloidosis
Identification of a unique transcriptomic signature associated with islet amyloidosis Open
Aims This cross-sectional study aims to identify potential transcriptomic changes conveyed by presence of amyloid deposits in islets from pancreatic tissue obtained from metabolically profiled living donors. Methods After establishing Thio…
View article: CDK4 deletion in mice prevents fat accumulation and increases endurance capacity through activation of estrogen-related receptor (ERR)-driven oxidative metabolism in skeletal muscle
CDK4 deletion in mice prevents fat accumulation and increases endurance capacity through activation of estrogen-related receptor (ERR)-driven oxidative metabolism in skeletal muscle Open
Cyclin-dependent kinase 4 (CDK4) canonical role is to control cell cycle progression from G1 to S phases. However, recent studies reported that CDK4 regulates energy metabolism in non-proliferating cells such as hepatocytes or adipocytes. …
View article: Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes Open
View article: Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes"
Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes" Open
Abstract: Wigger, Barovic, Brunner et al present a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled pancreatectomized living human donors stratified along the glycemic continuum,…
View article: Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes"
Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes" Open
Abstract: Wigger, Barovic, Brunner et al present a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled pancreatectomized living human donors stratified along the glycemic continuum,…
View article: CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions
CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions Open
View article: Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes Open
Existing studies do not sufficiently describe the molecular changes of pancreatic islet beta cells leading to their deficient insulin secretion in type 2 diabetes (T2D). Here we address this deficiency with a comprehensive multi-omics anal…
View article: Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion
Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion Open
Unexpectedly, the molecular pathogenesis of expanded CAG/CTG diseases does not include changes in 3D chromatin conformation.
View article: Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion
Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion Open
Expanded CAG/CTG repeats underlie thirteen neurological disorders, including myotonic dystrophy (DM1) and Huntington’s disease (HD). Upon expansion, CAG/CTG repeat loci acquire heterochromatic characteristics. This observation raises the h…
View article: The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans
The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans Open
Context Reduced β-cell mass, impaired islet function, and dedifferentiation are considered causal to development of hyperglycemia and type 2 diabetes. In human cohort studies, changes of islet cell–specific expression patterns have been as…
View article: HIV-1 Vpr and p21 restrict LINE-1 mobility
HIV-1 Vpr and p21 restrict LINE-1 mobility Open
Long interspersed element-1 (LINE-1, L1) composes ∼17% of the human genome. However, genetic interactions between L1 and human immunodeficiency virus type 1 (HIV-1) remain poorly understood. In this study, we found that HIV-1 suppresses L1…
View article: Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells
Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells Open
KAP1 is a universal corepressor for the large family of KRAB-ZFP proteins that coordinates epigenetic silencing of endogenous retroelements (EREs) during early embryonic development. This process is essential not just to prevent replicatio…