Flemming Bendtsen
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View article: Diagnostics of Autoimmune Hepatitis Enabled by Non-Invasive Clinical Proteomics.
Diagnostics of Autoimmune Hepatitis Enabled by Non-Invasive Clinical Proteomics. Open
NCT05335603.
View article: Clinical Trial: Evaluating a Single 1600 mg Tablet Regimen of 5‐Aminosalicylate for Ulcerative Colitis—The <scp>EASI</scp> Trial
Clinical Trial: Evaluating a Single 1600 mg Tablet Regimen of 5‐Aminosalicylate for Ulcerative Colitis—The <span>EASI</span> Trial Open
Background 5‐Aminosalicylate (5‐ASA) is recommended for the treatment of mild‐to‐moderate ulcerative colitis (UC). However, adherence may be low; poor adherence is associated with an increased risk for flares. Aim To investigate whether a …
View article: Low incidence of cytolysin-positive <i>E. faecalis</i> and no correlation to survival in Danish patients with alcohol-associated hepatitis: A prospective cohort study
Low incidence of cytolysin-positive <i>E. faecalis</i> and no correlation to survival in Danish patients with alcohol-associated hepatitis: A prospective cohort study Open
Alcohol-associated hepatitis (AH) is a severe and life-threatening form of alcohol-associated liver disease with no approved treatments for reducing long-term mortality. Cytolysin-producing E. faecalis in the gut microbiota of AH patients …
View article: Incidence and Long‐Term Outcomes of Pouchitis in Ulcerative Colitis Patients
Incidence and Long‐Term Outcomes of Pouchitis in Ulcerative Colitis Patients Open
Background Ileal pouch‐anal anastomosis (IPAA) is the preferred intervention for ulcerative colitis (UC) patients whose medical treatment fails. Acute severe ulcerative colitis (ASUC) can precipitate the need for urgent surgery, potentiall…
View article: Alterations in one-carbon metabolism in metabolic dysfunction associated steatotic liver disease may be modified by semaglutide
Alterations in one-carbon metabolism in metabolic dysfunction associated steatotic liver disease may be modified by semaglutide Open
MASLD may be linked to alterations in key metabolites and enzymes involved in OCM. The changes in humans were replicated in a MASLD mouse model, and reversal was found after treatment with semaglutide.
View article: Changes in Inflammatory Markers Following Bariatric Surgery and the Impact of the Surgical Procedure: A 12-Month Longitudinal Study
Changes in Inflammatory Markers Following Bariatric Surgery and the Impact of the Surgical Procedure: A 12-Month Longitudinal Study Open
View article: Mapping the hemodynamic effects of terlipressin in patients with hepatorenal syndrome using advanced magnetic resonance imaging
Mapping the hemodynamic effects of terlipressin in patients with hepatorenal syndrome using advanced magnetic resonance imaging Open
View article: Comparative Analysis of the Human Proteome Profile in Visceral Adipose and Liver Tissue in Individuals with Obesity with and Without MASLD and MASH
Comparative Analysis of the Human Proteome Profile in Visceral Adipose and Liver Tissue in Individuals with Obesity with and Without MASLD and MASH Open
Background/Objectives: Visceral adipose tissue (VAT) may play a direct role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to metabolic dysfunction-associated steatohepatitis (MAS…
View article: The Role of Environmental Factors Prior to Diagnosis on the Activity and Severity of Inflammatory Bowel Diseases—Results From the Prospective Population‐Based Copenhagen Inflammatory Bowel Disease Inception Cohort
The Role of Environmental Factors Prior to Diagnosis on the Activity and Severity of Inflammatory Bowel Diseases—Results From the Prospective Population‐Based Copenhagen Inflammatory Bowel Disease Inception Cohort Open
Background The influence of environmental factors on the severity of early inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is unclear. Herein, we aimed to investigate the role of environmental …
View article: Comparative Analysis of the Human Proteome Profile in visceral Adipose Tissue and Liver Tissue in Individuals with Obesity With and Without MASLD and MASH
Comparative Analysis of the Human Proteome Profile in visceral Adipose Tissue and Liver Tissue in Individuals with Obesity With and Without MASLD and MASH Open
Background/Objectives: Visceral adipose tissue (VAT) could be directly involved in the develop- ment of metabolic-associated steatotic liver disease (MASLD) and progression to metabol-ic-associated steatohepatitis (MASH). We employed untar…
View article: Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations Open
The microbiota in individual habitats differ in both relative composition and absolute abundance. While sequencing approaches determine the relative abundances of taxa and genes, they do not provide information on their absolute abundances…
View article: Reply: Statins for the prevention of cirrhosis complications: An American emulation of the StatLiver trial
Reply: Statins for the prevention of cirrhosis complications: An American emulation of the StatLiver trial Open
View article: Multidimensional Patient-Reported Outcomes and Quality of Life at Diagnosis of IBD: A Population-Based Inception Cohort Study
Multidimensional Patient-Reported Outcomes and Quality of Life at Diagnosis of IBD: A Population-Based Inception Cohort Study Open
We found a substantial patient-reported disease burden in newly diagnosed IBD, underscoring the importance of vigilant PRO monitoring in clinical practice.
View article: Thiopurines and the Risk of Cancer in Patients With Inflammatory Bowel Disease and Reference Individuals Without Inflammatory Bowel Disease: A Danish Nationwide Cohort Study (1996-2018)
Thiopurines and the Risk of Cancer in Patients With Inflammatory Bowel Disease and Reference Individuals Without Inflammatory Bowel Disease: A Danish Nationwide Cohort Study (1996-2018) Open
Thiopurines were associated with increased hazard of cancer, especially when used in combination therapy in the elderly. The hazard increased by 36% when patients were exposed to thiopurines for more than 5 years. Reassuringly, the hazard …
View article: A randomized controlled trial of a postdischarge nursing intervention for patients with decompensated cirrhosis
A randomized controlled trial of a postdischarge nursing intervention for patients with decompensated cirrhosis Open
Background: Few randomized trials have evaluated the effect of postdischarge interventions for patients with liver cirrhosis. This study assessed the effects of a postdischarge intervention on readmissions and mortality in patients with de…
View article: No difference in postprandial mesenteric blood flow between healthy younger and elderly individuals
No difference in postprandial mesenteric blood flow between healthy younger and elderly individuals Open
View article: Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations
Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations Open
The microbiota in individual habitats differ both in relative composition and absolute abundance. While sequencing approaches determine only the relative abundances of taxa and genes, experimental techniques for absolute abundance determin…
View article: Building an AI Support Tool for Real-Time Ulcerative Colitis Diagnosis
Building an AI Support Tool for Real-Time Ulcerative Colitis Diagnosis Open
View article: Targeted metabolomics reveals plasma short-chain fatty acids are associated with metabolic dysfunction-associated steatotic liver disease
Targeted metabolomics reveals plasma short-chain fatty acids are associated with metabolic dysfunction-associated steatotic liver disease Open
Background Alterations in the production of short-chain fatty acids (SCFAs) may reflect disturbances in the gut microbiota and have been linked to metabolic dysfunction-associated steatotic liver disease (MASLD). We assessed plasma SCFAs i…
View article: OP38 Should all patients with newly diagnosed inflammatory bowel diseases be screened for metabolic bone disease? Results from a Danish population-based inception cohort study
OP38 Should all patients with newly diagnosed inflammatory bowel diseases be screened for metabolic bone disease? Results from a Danish population-based inception cohort study Open
Background Inflammatory bowel diseases (IBD), encompassing ulcerative colitis (UC) and Crohn’s disease (CD), are associated with an increased risk of metabolic bone diseases (MBD). The aim of the current study was to evaluate for the occur…
View article: P375 Histological activity predicts the risk of colectomy after biological treatment in biological-naive patients with Ulcerative Colitis
P375 Histological activity predicts the risk of colectomy after biological treatment in biological-naive patients with Ulcerative Colitis Open
Background Treatment failure with biological agents is common in patients with ulcerative colitis (UC), but the impact of baseline histological disease activity is unknown. We aimed to investigate the predictive role of histopathological f…
View article: P330 Rate of disability at diagnosis in patients with inflammatory bowel diseases: Results from a prospective population-based inception cohort, IBD Prognosis Study
P330 Rate of disability at diagnosis in patients with inflammatory bowel diseases: Results from a prospective population-based inception cohort, IBD Prognosis Study Open
Background Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), are chronic, progressive diseases associated with a high level of disability over time. In the current study, we aimed to investigate…
View article: P240 The impact of environmental factors in the onset, activity and severity of inflammatory bowel diseases in a population-based Danish setting – findings from IBD Prognosis Study
P240 The impact of environmental factors in the onset, activity and severity of inflammatory bowel diseases in a population-based Danish setting – findings from IBD Prognosis Study Open
Background The role of environmental exposures in inflammatory bowel diseases (IBD) remains elusive despite their implicated significance. The aim of the current study was to investigate pre-diagnostic environmental factors affecting incid…
View article: P194 Health-related quality of life and fatigue in newly-diagnosed inflammatory bowel diseases: findings from a prospective population-based inception cohort, IBD Prognosis Study
P194 Health-related quality of life and fatigue in newly-diagnosed inflammatory bowel diseases: findings from a prospective population-based inception cohort, IBD Prognosis Study Open
Background Patients with inflammatory bowel diseases (IBD) often experience impaired quality of life (QoL) and fatigue. In the current study, we aimed to investigate QoL and fatigue at the time of IBD diagnosis and determine their associat…
View article: P1172 Epidemiology and initial presentation of newly diagnosed inflammatory bowel diseases in a Danish population-based inception cohort – results from the IBD Prognosis Study
P1172 Epidemiology and initial presentation of newly diagnosed inflammatory bowel diseases in a Danish population-based inception cohort – results from the IBD Prognosis Study Open
Background It is unclear whether the incidence of inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), continues to increase. In this study, we aimed to investigate the occurrence and initial disea…
View article: P1174 The disease course of elderly patients with Inflammatory Bowel Disease two years prior to their death
P1174 The disease course of elderly patients with Inflammatory Bowel Disease two years prior to their death Open
Background The number of elderly patients with inflammatory bowel disease (IBD) is increasing. Hence, more patients will be dying with their IBD. Limited research has examined the disease course of IBD in the aging body, particularly in th…
View article: P1166 Thiopurines and Risk of Cancer in Patients with Inflammatory Bowel Disease -A Danish Nationwide Cohort study 1996-2018
P1166 Thiopurines and Risk of Cancer in Patients with Inflammatory Bowel Disease -A Danish Nationwide Cohort study 1996-2018 Open
Background Thiopurines are frequently used in patients with inflammatory bowel disease (IBD). The aim of this study was to assess the cancer risk of thiopurine monotherapy and thiopurine in combination with biologics compared to unexposed …
View article: P381 Intestinal ultrasound in newly diagnosed Ulcerative Colitis predicts the need for colectomy
P381 Intestinal ultrasound in newly diagnosed Ulcerative Colitis predicts the need for colectomy Open
Background Upon diagnosis of ulcerative colitis (UC), it remains challenging to predict who will have a severe disease course, ultimately necessitating colectomy. Predictive tools capable of risk-stratifying patients and individualize trea…
View article: Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial
Atorvastatin for patients with cirrhosis. A randomized, placebo-controlled trial Open
Background: Patients with cirrhosis and portal hypertension face a high risk of complications. Besides their anti-inflammatory and antifibrotic effects, statins may reduce portal pressure and thus the risk of complications and mortality. W…
View article: Markers of inflammation predict survival in newly diagnosed cirrhosis: a prospective registry study
Markers of inflammation predict survival in newly diagnosed cirrhosis: a prospective registry study Open