Flemming Scheutz
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View article: Shiga Toxin-Producing E. coli (STEC) from Danish Patients, 1997–2023: Diagnostic Trends and Bacteriological Findings
Shiga Toxin-Producing E. coli (STEC) from Danish Patients, 1997–2023: Diagnostic Trends and Bacteriological Findings Open
Implementation of molecular detection methodology of Shiga toxin-producing Escherichia coli (STEC) in Danish patients began in 1997. Since then, changes in molecular detection methods and diagnostic criteria have led to the present situati…
The increasing incidence and mortality of bacteremia in Denmark from 2010 to 2022: a population-based nationwide cohort study Open
Objectives An increasing incidence of positive blood cultures has been reported in several countries. This represents an important challenge for public health due to the large number of hospital admissions with high mortality among these p…
Mandatory surveillance of bacteremia conducted by automated monitoring Open
Except for a few countries, comprehensive all-cause surveillance for bacteremia is not part of mandatory routine public health surveillance. We argue that time has come to include automated surveillance for bacteremia in the national surve…
Determinants of Sporadic Shiga Toxin-Producing Escherichia coli (STEC) Infection in Denmark, 2018–2020: A Matched Case–Control Study Open
Infections with Shiga toxin-producing Escherichia coli (STEC) are increasing in Denmark and elsewhere. STEC is also the most frequent cause of haemolytic uraemic syndrome (HUS) in Danish children. Most cases are considered sporadic, while …
Construction of the ETECFinder database for the characterization of enterotoxigenic <i>Escherichia coli</i> (ETEC) and revision of the VirulenceFinder web tool at the CGE website Open
The identification of pathogens is essential for effective surveillance and outbreak detection, which lately has been facilitated by the decreasing cost of whole-genome sequencing (WGS). However, extracting relevant virulence genes from WG…
View article: Identification and Characterization of ten Escherichia coli Strains Encoding Novel Shiga Toxin 2 Subtypes, Stx2n as Well as Stx2j, Stx2m, and Stx2o, in the United States
Identification and Characterization of ten Escherichia coli Strains Encoding Novel Shiga Toxin 2 Subtypes, Stx2n as Well as Stx2j, Stx2m, and Stx2o, in the United States Open
The sharing of genome sequences in online data repositories allows for large scale analyses of specific genes or gene families. This can result in the detection of novel gene subtypes as well as the development of improved detection method…
View article: Identification and Characterization of ten Escherichia coli Strains encoding Novel Shiga Toxin 2 Subtypes, Stx2n as well as Stx2j, Stx2m, and Stx2o, in the United States
Identification and Characterization of ten Escherichia coli Strains encoding Novel Shiga Toxin 2 Subtypes, Stx2n as well as Stx2j, Stx2m, and Stx2o, in the United States Open
The sharing of genome sequences in online data repositories, allows for large scale analyses of specific genes or gene families. This can result in the detection of novel gene subtypes as well as development of improved detection methods. …
Microbiological sampling and analyses in the food business operators’ HACCP-based self-control programmes Open
A questionnaire was developed within the OH-HARMONY-CAP project providing an overview of current procedures for microbiological sampling and analyses in food business operators’ HACCP-based self-control programmes in EU/EEA countries. It f…
Construction of the ETECFinder database for the characterisation of enterotoxigenic<i>Escherichia coli</i>(ETEC) and revision of the<i>VirulenceFinder</i>webtool at the CGE website Open
The identification of pathogens is essential for effective surveillance and outbreak detection, which has been facilitated by the decreasing cost of whole-genome sequencing (WGS). However, extracting relevant virulence genes from WGS data …
D-IA.2.2.OH-Harmony-Cap.2.4 Results and evaluation of the final survey Work package 2 of OH-Harmony-Cap: Development of the OHLabCap Open
This is a public deliverable of One Health EJP Joint Research Project, Integrative Action-2.3, OH-Harmony-Cap: One Health Harmonisation of Protocols for the Detection of Foodborne Pathogens and AMR Determinants. https://onehealthejp.eu/jip…
Cumulative acquisition of pathogenicity islands has shaped virulence potential and contributed to the emergence of LEE-negative Shiga toxin-producing <i>Escherichia coli</i> strains Open
Shiga toxin-producing Escherichia coli (STEC) are foodborne pathogens causing severe gastroenteritis, which may lead to hemolytic uremic syndrome. The Locus of Enterocyte Effacement (LEE), a Pathogenicity Island (PAI), is a major determina…
Characterization of Atypical Shiga Toxin Gene Sequences and Description of Stx2j, a New Subtype Open
Shiga toxin (Stx) is the definitive virulence factor of Shiga toxin-producing Escherichia coli (STEC). Stx variants are currently organized into a taxonomic system of three Stx1 (a, c, and d) and seven Stx2 (a, b, c, d, e, f, and g) subtyp…
Characterization of Atypical Shiga Toxin Gene Sequences and Description of Stx2j, a New Subtype Open
Shiga toxin (Stx) is the definitive virulence factor of Shiga toxin-producing Escherichia coli (STEC). Stx variants are currently organized into a taxonomic system of three Stx1 (a, c, and d) and seven Stx2 (a, b, c, d, e, f, and g) subtyp…
Characterization of Atypical Shiga Toxin Gene Sequences and Description of Stx2j, a New Subtype Open
Shiga toxin (Stx) is the definitive virulence factor of Shiga toxin-producing Escherichia coli (STEC). Stx variants are currently organized into a taxonomic system of three Stx1 (a, c, and d) and seven Stx2 (a, b, c, d, e, f, and g) subtyp…
Characterization of Clinical Escherichia coli Strains Producing a Novel Shiga Toxin 2 Subtype in Sweden and Denmark Open
Shiga toxin (Stx) is the key virulence factor in the Shiga Toxin-Producing Escherichia coli (STEC), which can cause diarrhea and hemorrhagic colitis with potential life-threatening complications. There are two major types of Stx: Stx1 and …
Characterization of Clinical Escherichia coli Strains Producing a Novel Shiga Toxin 2 Subtype in Sweden and Denmark Open
Shiga toxin (Stx) is the key virulence factor in the Shiga Toxin-Producing Escherichia coli (STEC), which can cause diarrhea and hemorrhagic colitis with potential life-threatening complications. There are two major types of Stx: Stx1 and …
View article: Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms Open
We analyzed and compared genomes of Extended Spectrum Beta-Lactamase (ESBL)-producing Escherichia coli from pigs and pig farm workers at 116 farms in Vietnam. Analyses revealed the presence of blaCTX-M-55, blaCTX-M-27, blaCTX-M-15, blaCTX-…
Cumulative acquisition of pathogenicity islands has shaped virulence potential and contributed to the emergence of LEE-negative Shiga toxin-producing <i>Escherichia coli</i> strains Open
Shiga toxin-producing Escherichia coli (STEC) are foodborne pathogens causing severe gastroenteritis, which may lead to hemolytic uremic syndrome. The Locus of Enterocyte Effacement (LEE), a Pathogenicity Island (PAI), is a major determina…
Deliverable D-IA.2.2.OH-Harmony-Cap.2.1: Completed Pilot Survey Open
This is a public deliverable of One Health EJP Joint Research Project, Integrative Action-2.2, OH-HARMONY-CAP: One Health Harmonisation of Protocols for the Detection of Foodborne Pathogens and AMR Determinants. https://onehealthejp.eu/jip…
Deliverable D-IA.2.2.OH-Harmony-Cap.2.1: Completed Pilot Survey Open
This is a public deliverable of One Health EJP Joint Research Project, Integrative Action-2.2, OH-HARMONY-CAP: One Health Harmonisation of Protocols for the Detection of Foodborne Pathogens and AMR Determinants. https://onehealthejp.eu/jip…
OH-Harmony-Cap Data Management Plan Open
This is a public deliverable of One Health EJP Joint Research Project, Integrative Action-2.2, OH-HARMONY-CAP: One Health Harmonisation of Protocols for the Detection of Foodborne Pathogens and AMR Determinants https://onehealthejp.eu/jip-…
Redefining enteroaggregative Escherichia coli (EAEC): Genomic characterization of epidemiological EAEC strains Open
Although enteroaggregative E. coli (EAEC) has been implicated as a common cause of diarrhea in multiple settings, neither its essential genomic nature nor its role as an enteric pathogen are fully understood. The current definition of this…
<i>In Silico</i> Genotyping of Escherichia coli Isolates for Extraintestinal Virulence Genes by Use of Whole-Genome Sequencing Data Open
Extraintestinal pathogenic Escherichia coli (ExPEC) is the leading cause in humans of urinary tract infection and bacteremia. The previously published web tool VirulenceFinder ( http://cge.cbs.dtu.dk/services/VirulenceFinder/ ) uses whole-…
View article: Emergence of Enteroaggregative Escherichia coli within the ST131 Lineage as a Cause of Extraintestinal Infections
Emergence of Enteroaggregative Escherichia coli within the ST131 Lineage as a Cause of Extraintestinal Infections Open
E. coli ST131 is an important extraintestinal pathogenic lineage. A signature characteristic of ST131 is its ability to asymptomatically colonize the gastrointestinal tract and then opportunistically cause extraintestinal infections, such …
View article: Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone Open
Multidrug-resistant Escherichia coli ST131 fimH30 responsible for extra-intestinal pathogenic (ExPEC) infections is globally distributed. However, the occurrence of a subclone fimH27 of ST131 harboring both ExPEC and enteroaggregative E. c…
Pathogenicity assessment of Shiga toxin‐producing Escherichia coli (STEC) and the public health risk posed by contamination of food with STEC Open
The provisional molecular approach, proposed by EFSA in 2013, for the pathogenicity assessment of Shiga toxin-producing Escherichia coli (STEC) has been reviewed. Analysis of the confirmed reported human STEC infections in the EU/EEA (2012…
gndDb, a Database of Partial <i>gnd</i> Sequences To Assist with Analysis of Escherichia coli Communities Using High-Throughput Sequencing Open
The use of culture methods to detect Escherichia coli diversity does not provide sufficient resolution to identify strains present at low levels. Here, we target the hypervariable gnd gene and describe a database containing 534 distinct pa…