Fleur A. de Groot
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View article: Non-inferior outcome of abbreviated R-CHOP in patients with stage I primary testicular lymphoma
Non-inferior outcome of abbreviated R-CHOP in patients with stage I primary testicular lymphoma Open
In this nationwide cohort, nearly half of stage I PTL patients received 3 R-CHOP cycles without inferior outcomes. These real-world findings suggest de-escalation to 3 cycles may be a safe treatment approach in stage I patients and warrant…
View article: MATRix and HD-MTX/IFO/DEP treatment and autologous stem cell transplantation in secondary central nervous system lymphoma: a Dutch retrospective analysis
MATRix and HD-MTX/IFO/DEP treatment and autologous stem cell transplantation in secondary central nervous system lymphoma: a Dutch retrospective analysis Open
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View article: Superior survival in diffuse large B cell lymphoma of the bone with immune rich tumor microenvironment
Superior survival in diffuse large B cell lymphoma of the bone with immune rich tumor microenvironment Open
With tumor genomic and gene-expression profiling (GEP), this study investigated the immune-molecular signatures of a unique cohort of diffuse large B-cell lymphoma of the bone (bone-DLBCL), including primary bone (PB-DLBCL, n = 52) and pol…
View article: Unveiling Transformation Mechanisms of Nodal Marginal Zone Lymphoma Using a Multi-Omics Approach
Unveiling Transformation Mechanisms of Nodal Marginal Zone Lymphoma Using a Multi-Omics Approach Open
Introduction: Approximately 8% of nodal marginal zone lymphoma (NMZL) patients experience transformation into diffuse large B-cell lymphoma (DLBCL) within 5 years from diagnosis (PMID 37658062). Transformation of NMZL (tNMZL) is associated…
View article: Clinical characteristics and survival outcomes of patients with primary central nervous system lymphoma treated with high-dose methotrexate-based polychemotherapy and consolidation therapies
Clinical characteristics and survival outcomes of patients with primary central nervous system lymphoma treated with high-dose methotrexate-based polychemotherapy and consolidation therapies Open
Given the rarity of primary central nervous system lymphoma (PCNSL), evaluations of different high-dose methotrexate-(HD-MTX)-based treatment regimens is sparse. This retrospective, multicenter study evaluates clinical characteristics and …
View article: The Genetic Profile of Large B-Cell Lymphomas Presenting in the Ocular Adnexa
The Genetic Profile of Large B-Cell Lymphomas Presenting in the Ocular Adnexa Open
To provide insights into targetable oncogenic pathways, this retrospective cohort study investigated the genetic profile of 26 patients with diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS), and two patients with high-gra…
View article: Sinonasal DLBCL: molecular profiling identifies subtypes with distinctive prognosis and targetable genetic features
Sinonasal DLBCL: molecular profiling identifies subtypes with distinctive prognosis and targetable genetic features Open
Primary sinonasal diffuse large B-cell lymphoma (PSDLBCL) is a rare lymphoma with a variable prognosis and a unique relapse/dissemination pattern involving the central nervous system and skin. The underlying molecular mechanisms leading to…
View article: A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma
A significant proportion of classic Hodgkin lymphoma recurrences represents clonally unrelated second primary lymphoma Open
Despite high cure rates in classic Hodgkin lymphoma (cHL), relapses are observed. Whether relapsed cHL represents second primary lymphoma or an underlying T-cell lymphoma (TCL) mimicking cHL is underinvestigated. To analyze the nature of c…
View article: Biological and Clinical Implications of Gene-Expression Profiling in Diffuse Large B-Cell Lymphoma: A Proposal for a Targeted BLYM-777 Consortium Panel as Part of a Multilayered Analytical Approach
Biological and Clinical Implications of Gene-Expression Profiling in Diffuse Large B-Cell Lymphoma: A Proposal for a Targeted BLYM-777 Consortium Panel as Part of a Multilayered Analytical Approach Open
Gene-expression profiling (GEP) is used to study the molecular biology of lymphomas. Here, advancing insights from GEP studies in diffuse large B-cell lymphoma (DLBCL) lymphomagenesis are discussed. GEP studies elucidated subtypes based on…
View article: Frequent mutated <i>B2M</i>, <i>EZH2</i>, <i>IRF8</i>, and <i>TNFRSF14</i> in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype
Frequent mutated <i>B2M</i>, <i>EZH2</i>, <i>IRF8</i>, and <i>TNFRSF14</i> in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype Open
Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a rare extranodal lymphoma subtype. This retrospective study elucidates the currently unknown genetic background of a large clinically well-annotated cohort of DLBCL with osseous loc…
View article: Shoulder movement complexity in the aging shoulder: A cross‐sectional analysis and reliability assessment
Shoulder movement complexity in the aging shoulder: A cross‐sectional analysis and reliability assessment Open
Healthy individuals perform a task such as hitting the head of a nail with an infinite coordination spectrum. This motor redundancy is healthy and allows for learning through exploration and uniform load distribution across muscles. Assess…