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View article: Trajectories of allergic diseases in children: Destination unknown?
Trajectories of allergic diseases in children: Destination unknown? Open
The trajectories of allergic diseases represent one of the most currently debated topics both when referred to childhood and likewise adulthood. Data from cohorts show their heterogeneity as well as the key role of genetic and environmenta…
View article: Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics
Severe Paediatric Asthma Collaborative in Europe: real-world data on children on biologics Open
Introduction Real-world data on children with severe asthma is scarce. We report characteristics of children with severe asthma already on biologics, enrolled in the Severe Paediatric Asthma Collaborative in Europe, a clinical research col…
View article: Molecular allergen sensitization drives phenotypes of severe asthma in children: Evidence from a megacity cohort (<scp>SAMP</scp>)
Molecular allergen sensitization drives phenotypes of severe asthma in children: Evidence from a megacity cohort (<span>SAMP</span>) Open
Background Several major sensitization profiles have been described in children with asthma, but it remains unclear how these profiles relate to asthma phenotypes. The aim of this study was to determine allergenic sensitization profiles in…
View article: Actual food consumption after a negative oral food challenge in children: A challenge after the challenge?
Actual food consumption after a negative oral food challenge in children: A challenge after the challenge? Open
A negative OFC does not always result in actual consumption of the tested food at home. These results underline the importance of performing an OFC as early as possible in the patient's life. Monitoring and supporting patients who have a n…
View article: Features of children with critical asthma hospitalized in a pediatric intensive care unit: Results from the ICU‐3A study
Features of children with critical asthma hospitalized in a pediatric intensive care unit: Results from the ICU‐3A study Open
Introduction Despite improvements in long‐term asthma treatment, an increasing number of children are being hospitalized in pediatric intensive care units (PICU) for asthma. The main objective of this study was to describe a recent cohort …
View article: Molecular allergen sensitization drives phenotypes of severe asthma in children: evidence from a megacity cohort (SAMP)
Molecular allergen sensitization drives phenotypes of severe asthma in children: evidence from a megacity cohort (SAMP) Open
Background : Several major sensitization profiles have been described in children with asthma, but it remains unclear how these profiles relate to asthma phenotypes. The aim of this study was to determine allergenic sensitization profiles …
View article: <scp>COBRAPed</scp> cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?
<span>COBRAPed</span> cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease? Open
Background It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with non‐severe recurrent wheeze (NSRW)/non‐severe asthma (NSA). Our objective was to determine…
View article: Objectives for algorithmic decision-making systems in childhood asthma: Perspectives of children, parents, and physicians
Objectives for algorithmic decision-making systems in childhood asthma: Perspectives of children, parents, and physicians Open
Objectives To identify with children, parents and physicians the objectives to be used as parameters for algorithmic decision-making systems (ADMSs) adapting treatments in childhood asthma. Methods We first conducted a qualitative study ba…
View article: COBRAPed cohort: Sensitization patterns do not differentiate children with severe asthma from those with a milder disease
COBRAPed cohort: Sensitization patterns do not differentiate children with severe asthma from those with a milder disease Open
Background: It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW) / severe asthma (SA) from those with non-severe recurrent wheeze (NSRW) / non-severe asthma (NSA). Our objective was to comp…
View article: Rhinovirus Infection and Familial Atopy Predict Persistent Asthma and Sensitisation 7 Years after a First Episode of Acute Bronchiolitis in Infancy
Rhinovirus Infection and Familial Atopy Predict Persistent Asthma and Sensitisation 7 Years after a First Episode of Acute Bronchiolitis in Infancy Open
Background: We set out to assess the risk factors for asthma outcome in a cohort of infants who experienced their first episode of acute bronchiolitis. Methods: A cohort of 222 infants who were included during a first episode of acute bron…
View article: Risk factors for emergency department visit in a prospective open cohort of asthmatic children
Risk factors for emergency department visit in a prospective open cohort of asthmatic children Open
BackgroundRisk factors of emergency department (ED) visits have mainly been obtained from hospital cohorts.ObjectiveTo evaluate risk factors for ED visits in asthmatic children in an out-of-hospital cohort.MethodsWe led a prospective study…
View article: Determinants of blood eosinophilia in moderate and severe asthmatic patients during childhood: Evidence from the severe asthma molecular phenotype (SAMP) cohort
Determinants of blood eosinophilia in moderate and severe asthmatic patients during childhood: Evidence from the severe asthma molecular phenotype (SAMP) cohort Open
Background Asthma is a heterogeneous disease in which the interaction between genetic and environmental factors plays a major role. The significance of blood eosinophil is unclear. The aim of the study was to determine the significance of …
View article: Small airway dysfunction is an independent dimension of wheezing disease in preschool children
Small airway dysfunction is an independent dimension of wheezing disease in preschool children Open
Background. Whether small airway dysfunction (SAD), which is prevalent in asthma, helps to characterize wheezing phenotypes is undetermined. The objective was to assess whether SAD parameters obtained from impedance measurement and asthma …
View article: Childhood-onset severe hypereosinophilic asthma: efficacy of benralizumab
Childhood-onset severe hypereosinophilic asthma: efficacy of benralizumab Open
Severe hypereosinophilic asthma in children is extremely rare. This letter adds to the existing literature by providing long-term follow-up, and is the first report of the marked efficacy of benralizumab after failure of other biologic tre…
View article: Correlation between work impairment, scores of rhinitis severity and asthma using the MASK‐air<sup>®</sup>App
Correlation between work impairment, scores of rhinitis severity and asthma using the MASK‐air<sup>®</sup>App Open
Background In allergic rhinitis, a relevant outcome providing information on the effectiveness of interventions is needed. In MASK‐air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for work is used as a relevant outcome.…
View article: Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis
Urinary club cell protein 16 (CC16): Utility of its assay during acute bronchiolitis Open
Acute bronchiolitis is responsible for high morbidity in infants. Club cell protein 16 kDa (CC16) is a major pneumoprotein secreted by club cells of the bronchial epithelium and eliminated by the renal pathway. CC16 seems to be a biomarker…
View article: Issue Information ‐ TOC
Issue Information ‐ TOC Open
Local rhinitis needs allergen-challenges for diagnosis, late infancy supplementation of probiotics prevents eczema, and milk oral immunotherapy is effective in the long term P. Eigenmann 259 Guidance for assessment of erythroderma in neona…
View article: MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence
MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence Open
mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching …
View article: Biomarkers for severe allergic asthma in children: could they be useful to guide disease control and use of omalizumab?
Biomarkers for severe allergic asthma in children: could they be useful to guide disease control and use of omalizumab? Open
Although symptom controls in asthmatic children can be achieved through compliant use of conventional medication, some children have uncontrolled severe persistent asthma, especially if they are allergic. For these children, omalizumab (ap…
View article: New insights into the phenotypes of atopic dermatitis linked with allergies and asthma in children: An overview
New insights into the phenotypes of atopic dermatitis linked with allergies and asthma in children: An overview Open
Summary Atopic dermatitis ( AD ) is a complex disease with multiple causes and complex mechanistic pathways according to age of onset, severity of the illness, ethnic modifiers, response to therapy and triggers. A group of difficult‐to‐man…
View article: RSV‐hRV co‐infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis
RSV‐hRV co‐infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis Open
To assess risk factors of recurrent bronchial obstruction and allergic sensitization 3 years after an episode of acute bronchiolitis, whether after ambulatory care treatment or hospitalization. A monocentric prospective longitudinal study …