Anthony Mathur
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View article: Prevention of acute myocardial infarction induced heart failure by intracoronary infusion of mesenchymal stem cells: phase 3 randomised clinical trial (PREVENT-TAHA8)
Prevention of acute myocardial infarction induced heart failure by intracoronary infusion of mesenchymal stem cells: phase 3 randomised clinical trial (PREVENT-TAHA8) Open
Objective To assess the effect of intracoronary infusion of mesenchymal stem cells on the development of post-myocardial infarction heart failure. Design Phase 3 randomised clinical trial. Setting Three tertiary hospitals in Shiraz, Iran. …
View article: Implications of computed tomography reconstruction algorithms on coronary atheroma composition: A head-to-head comparison with multimodality near-infrared spectroscopy intravascular ultrasound imaging
Implications of computed tomography reconstruction algorithms on coronary atheroma composition: A head-to-head comparison with multimodality near-infrared spectroscopy intravascular ultrasound imaging Open
CTA reconstruction parameters influence plaque composition analysis. The combination of an intermediate-strength IR, thin slice thickness, and fixed HU cutoffs yields the most accurate tissue characterization compared to NIRS-IVUS as the r…
View article: A deep learning methodology for fully-automated quantification of calcific burden in high-resolution intravascular ultrasound images
A deep learning methodology for fully-automated quantification of calcific burden in high-resolution intravascular ultrasound images Open
Purpose Quantification of the calcific burden is valuable in percutaneous coronary intervention (PCI) planning and in research to assess its changes after pharmacotherapies targeting plaque progression. In intravascular ultrasound (IVUS) i…
View article: Transendocardial Injection of Expanded Autologous CD34+ Cells After Myocardial Infarction
Transendocardial Injection of Expanded Autologous CD34+ Cells After Myocardial Infarction Open
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View article: BS05 Assessment of turbulent aortic flow patterns in clinical regions of interest for durable transcatheter aortic valve implantation
BS05 Assessment of turbulent aortic flow patterns in clinical regions of interest for durable transcatheter aortic valve implantation Open
View article: 2-057 An analysis of differences in discharge medications following STEMI by ethnicity: a single-centre retrospective study
2-057 An analysis of differences in discharge medications following STEMI by ethnicity: a single-centre retrospective study Open
View article: Morphology and calcification characterization in patients undergoing TAVI: A 3D statistical shape modelling study
Morphology and calcification characterization in patients undergoing TAVI: A 3D statistical shape modelling study Open
Aortic stenosis (AS) is a common valvular disease becoming more prevalent globally due to the aging of the population. Transcatheter aortic valve implantation (TAVI) is a minimally invasive intervention indicated for AS patients as alterna…
View article: A novel framework for fully-automated co-registration of intravascular ultrasound and optical coherence tomography imaging data
A novel framework for fully-automated co-registration of intravascular ultrasound and optical coherence tomography imaging data Open
Aims: To develop a deep-learning (DL) framework that will allow fully automated longitudinal and circumferential co-registration of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images. Methods and results: Data fr…
View article: Implications of imaging modalities on coronary vessel reconstruction and computation of the local hemodynamic forces
Implications of imaging modalities on coronary vessel reconstruction and computation of the local hemodynamic forces Open
A strong association was noted for the ESS estimated in the hybrid NIRS-IVUS-based reconstructions with CCTA appearing as the 2nd best modality for assessing the local hemodynamic milieu.
View article: Cost-Effectiveness of Early Discharge (<48 Hours) for Low-Risk Patients Following PPCI for STEMI
Cost-Effectiveness of Early Discharge (<48 Hours) for Low-Risk Patients Following PPCI for STEMI Open
Selected low-risk patients can be discharged securely and safely following successful primary percutaneous coronary intervention using a pathway that is reinforced by a formal, multidisciplinary virtual follow-up program, enabling improvem…
View article: Clinical phenotypes in hypertension: a data-driven approach to risk stratification and outcome prediction
Clinical phenotypes in hypertension: a data-driven approach to risk stratification and outcome prediction Open
Background Hypertension (HTN) is a major contributor to cardiovascular (CV) morbidity and mortality. Its heterogeneity complicates risk stratification. Unsupervised machine learning can identify risk profiles and refine preventative strate…
View article: Left Ventricular Unloading in Nonischemic Dilated Cardiomyopathy Improves Coronary Haemodynamic Reserve
Left Ventricular Unloading in Nonischemic Dilated Cardiomyopathy Improves Coronary Haemodynamic Reserve Open
Background The Impella CP is a catheter‐based ventricular assist device used in the management of cardiogenic shock and to support high‐risk percutaneous coronary interventions (PCI). Despite its growing use, the effects of Impella CP on c…
View article: The Association of Socioeconomic Status (SES) with Procedural Management and Mortality After Percutaneous Coronary Intervention (PCI): An Observational Study from the Pan-London PCI (BCIS) Registry
The Association of Socioeconomic Status (SES) with Procedural Management and Mortality After Percutaneous Coronary Intervention (PCI): An Observational Study from the Pan-London PCI (BCIS) Registry Open
Background: Lower socioeconomic status (SES) has been associated with increased mortality from coronary heart disease. This excess risk, relative to affluent patients, may be due to a combination of more adverse cardiovascular-risk factors…
View article: Examination of the performance of machine learning-based automated coronary plaque characterization by near-infrared spectroscopy–intravascular ultrasound and optical coherence tomography with histology
Examination of the performance of machine learning-based automated coronary plaque characterization by near-infrared spectroscopy–intravascular ultrasound and optical coherence tomography with histology Open
Aims Near-infrared spectroscopy–intravascular ultrasound (NIRS–IVUS) and optical coherence tomography (OCT) can assess coronary plaque pathology but are limited by time-consuming and expertise-driven image analysis. Recently introduced mac…
View article: T1 signal intensity ratio variability based on sampling strategies in the pancreas of children and young adults
T1 signal intensity ratio variability based on sampling strategies in the pancreas of children and young adults Open
View article: What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?
What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? Open
Accurate evaluation of coronary artery pathology is essential for risk stratification and tailoring appropriate treatment. Intravascular imaging was introduced for this purpose 40 years ago enabling for the first time in vivo plaque charac…
View article: Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement
Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement Open
BACKGROUND: In aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. Following aortic valve rep…
View article: Computed tomography versus near-infrared spectroscopy for the assessment of coronary atherosclerosis
Computed tomography versus near-infrared spectroscopy for the assessment of coronary atherosclerosis Open
CCTA has limited efficacy in assessing plaque composition and quantifying lumen and plaque dimensions and tissue types, which may potentially impact revascularisation planning.
View article: Relationship between smoking and pulmonary tuberculosis based on positive sputum smears
Relationship between smoking and pulmonary tuberculosis based on positive sputum smears Open
Introduction: Smoking and tuberculosis are the two major, global health problems. Not only active smokers but also passive smokers are at risk of becoming infected with tuberculosis. Through many mechanisms, smoking decreases immunity and …
View article: The Association of Socioeconomic Status (SES) with Procedural Management and Mortality After Percutaneous Coronary Intervention (PCI): An Observational Study from the Pan-London PCI (BCIS) Registry
The Association of Socioeconomic Status (SES) with Procedural Management and Mortality After Percutaneous Coronary Intervention (PCI): An Observational Study from the Pan-London PCI (BCIS) Registry Open
Background:Lower socioeconomic status (SES) has been associated with increased mortality from coronary heart disease. This excess risk, relative to affluent patients, may be due to a combination of more adverse cardiovascular‐risk factors,…
View article: The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial
The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial Open
This trial and KSR was funded by the National Institute for Health and Care Research (NIHR) (DRF-2014-07-008) and NIHR ACL, HW and this study were supported by The NIHR Barts Biomedical Research Centre, IC was funded by The North and East …
View article: Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial
Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial Open
Background Despite tremendous therapeutic advancements, a significant proportion of coronary artery disease patients suffer from refractory angina pectoris, that is, quality-of-life-compromising angina that is non-manageable with establish…
View article: Implications of coronary calcification on the assessment of plaque pathology: a comparison of computed tomography and multimodality intravascular imaging
Implications of coronary calcification on the assessment of plaque pathology: a comparison of computed tomography and multimodality intravascular imaging Open
View article: Rapid prediction of wall shear stress in stenosed coronary arteries based on deep learning
Rapid prediction of wall shear stress in stenosed coronary arteries based on deep learning Open
There is increasing evidence that coronary artery wall shear stress (WSS) measurement provides useful prognostic information that allows prediction of adverse cardiovascular events. Computational Fluid Dynamics (CFD) has been extensively u…
View article: REGENERATE-COBRA: A phase II randomized sham-controlled trial assessing the safety and efficacy of intracoronary administration of autologous bone marrow-derived cells in patients with refractory angina
REGENERATE-COBRA: A phase II randomized sham-controlled trial assessing the safety and efficacy of intracoronary administration of autologous bone marrow-derived cells in patients with refractory angina Open
This is the first trial to assess the safety and efficacy of an intracoronary infusion of autologous bone marrow-derived unfractionated mononuclear cells in symptomatic refractory angina patients who have exhausted conventional therapeutic…
View article: Non-ST-elevation acute coronary syndromes with previous coronary artery bypass grafting: a meta-analysis of invasive vs. conservative management
Non-ST-elevation acute coronary syndromes with previous coronary artery bypass grafting: a meta-analysis of invasive vs. conservative management Open
Background and Aims A routine invasive strategy is recommended in the management of higher risk patients with non-ST-elevation acute coronary syndromes (NSTE-ACSs). However, patients with previous coronary artery bypass graft (CABG) surger…
View article: Contrast Volume-to-Estimated Glomerular Filtration Rate Ratio as a Predictor of Short-Term Outcomes Following Transcatheter Aortic Valve Implantation
Contrast Volume-to-Estimated Glomerular Filtration Rate Ratio as a Predictor of Short-Term Outcomes Following Transcatheter Aortic Valve Implantation Open
Background/Objectives: Contrast-induced acute kidney injury (AKI) is associated with early mortality and adverse events. However, in the setting of transcatheter aortic valve implantation (TAVI), previous literature has failed to establish…
View article: Sex differences in optimal medical therapy following invasive angiography for coronary artery disease
Sex differences in optimal medical therapy following invasive angiography for coronary artery disease Open
Funding Acknowledgements Type of funding sources: Other. Main funding source(s): HARP Wellcome Trust PhD Fellowship Grant & NIHR Biomedical Research Centre Introduction Coronary artery disease (CAD) remains the number one cause of death in…
View article: Inorganic nitrate benefits contrast-induced nephropathy after coronary angiography for acute coronary syndromes: the NITRATE-CIN trial
Inorganic nitrate benefits contrast-induced nephropathy after coronary angiography for acute coronary syndromes: the NITRATE-CIN trial Open
Background and Aims Contrast-induced nephropathy (CIN), also known as contrast-associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity and mortality following coronary angiographic procedures in high-ris…
View article: Prognostic Impact of Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Implantation
Prognostic Impact of Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Implantation Open