Éric Florence
YOU?
Author Swipe
View article: Epidemiological, clinical, and biological profiles of People Living With HIV in the PMTCT department of Panzi hospital: a retrospective cohort study in Eastern DR. Congo
Epidemiological, clinical, and biological profiles of People Living With HIV in the PMTCT department of Panzi hospital: a retrospective cohort study in Eastern DR. Congo Open
Among the 9,143 women enrolled in PMTCT, 6,318 were tested, of whom 256 (4.1%) were HIV-positive, including 112 pregnant women (1.8%). Compared with their HIV-negative counterparts, HIV-positive pregnant women had lower antenatal care atte…
View article: Epidemiological, clinical, and biological profiles of HIV-infected pregnant women in the PMTCT department of Panzi Hospital: A retrospective cohort study in eastern DR. Congo
Epidemiological, clinical, and biological profiles of HIV-infected pregnant women in the PMTCT department of Panzi Hospital: A retrospective cohort study in eastern DR. Congo Open
Introduction: Screening and surveillance of HIV infected pregnant women remains a public health problem in the Democratic Republic of Congo. This study’s aim was to assess the epidemiological, clinical, and biological profiles of HIV-infec…
View article: An assessment of circulating biomarkers and germline genetic variants in predicting chemotherapy associated mucositis in Ewing sarcoma
An assessment of circulating biomarkers and germline genetic variants in predicting chemotherapy associated mucositis in Ewing sarcoma Open
Background: Treatment of Ewing sarcoma is associated with severe toxicities including chemotherapy-induced mucositis. Here we investigated the role of circulating biomarkers and genetic factors in predicting mucositis severity in Ewing sar…
View article: Evaluating the Genetic Landscape of (Plasmodium falciparum) PfKelch13 Gene Polymorphisms in Côte d'Ivoire Following a Decade of Artemisinin-based Combination Therapy
Evaluating the Genetic Landscape of (Plasmodium falciparum) PfKelch13 Gene Polymorphisms in Côte d'Ivoire Following a Decade of Artemisinin-based Combination Therapy Open
Introduction: Artemisinin-based combination therapies (ACTs) are the mainstay of malaria treatment globally. However, their effectiveness is threatened by the emergence of resistance in Plasmodium falciparum (P.f), particularly in Southeas…
View article: Assessing the Effectiveness of an mHealth Intervention to Support Men Who Have Sex With Men Engaging in Chemsex (Budd): Single-Case and Pre-Post Experimental Design Study
Assessing the Effectiveness of an mHealth Intervention to Support Men Who Have Sex With Men Engaging in Chemsex (Budd): Single-Case and Pre-Post Experimental Design Study Open
Background This study focuses on the Budd app, a mobile health intervention designed for gay, bisexual, and other men who have sex with men who participate in chemsex. Chemsex, the use of psychoactive drugs in a sexual context, presents su…
View article: Pre-exposure prophylaxis (PrEP) use trajectories and incidence of HIV and other sexually transmitted infections among PrEP users in Belgium: a cohort analysis of insurance claims data from 2017 to 2019
Pre-exposure prophylaxis (PrEP) use trajectories and incidence of HIV and other sexually transmitted infections among PrEP users in Belgium: a cohort analysis of insurance claims data from 2017 to 2019 Open
The study highlights challenges in PrEP persistence and a high incidence of bacterial STIs among individuals receiving PrEP. Tailored prevention support is crucial for individuals with ongoing HIV risk to optimise PrEP effectiveness. Integ…
View article: Integrase Strand Transfer Inhibitor–Related Changes in Body Mass Index and Risk of Diabetes: A Prospective Study From the RESPOND Cohort Consortium
Integrase Strand Transfer Inhibitor–Related Changes in Body Mass Index and Risk of Diabetes: A Prospective Study From the RESPOND Cohort Consortium Open
Background With integrase strand transfer inhibitor (INSTI) use associated with increased body mass index (BMI) and BMI increases associated with higher diabetes mellitus (DM) risk, we explored the relationships between INSTI/non-INSTI reg…
View article: The impact of analytical treatment interruptions and trial interventions on time to viral re‐suppression in people living with HIV restarting ART in cure‐related clinical studies: a systematic review and meta‐analysis
The impact of analytical treatment interruptions and trial interventions on time to viral re‐suppression in people living with HIV restarting ART in cure‐related clinical studies: a systematic review and meta‐analysis Open
Introduction To assess the effectiveness of novel HIV curative strategies, “cure” trials require periods of closely monitored antiretroviral therapy (ART) analytical treatment interruptions (ATIs). We performed a systematic review and meta…
View article: Correction for Van Gulck et al., “A truncated HIV Tat demonstrates potent and specific latency reversal activity”
Correction for Van Gulck et al., “A truncated HIV Tat demonstrates potent and specific latency reversal activity” Open
Volume 67, no. 11, e00417-23, 2023, https://doi.org/10.1128/aac.00417-23. Page 3: Figure 1 should appear as shown in this correction. In the original article, Fig. 1 was inadvertently a duplicate of Fig. 2.
View article: Safety and Effectiveness From the Cabotegravir and Rilpivirine Implementation Study in European Locations Study: Phase 3b Hybrid Type III Implementation Study Integrating Cabotegravir + Rilpivirine Long-Acting Into European Clinical Settings
Safety and Effectiveness From the Cabotegravir and Rilpivirine Implementation Study in European Locations Study: Phase 3b Hybrid Type III Implementation Study Integrating Cabotegravir + Rilpivirine Long-Acting Into European Clinical Settings Open
Background: Cabotegravir + rilpivirine long-acting (CAB + RPV LA) dosed every 2 months (Q2M) is a complete regimen for the maintenance of HIV-1 virologic suppression. In this study, we report month 12 clinical outcomes in patient study par…
View article: A characterization of the HIV population with limited/exhausted treatment options: a multicenter Belgian study
A characterization of the HIV population with limited/exhausted treatment options: a multicenter Belgian study Open
In this analysis of PLWH in Belgium, individuals with limited/exhausted treatment options represented a small fraction. Most were on a 3-drug ART regimen, were virologically suppressed, and had a CD4+ T-cell count within normal …
View article: Uptake and challenges with daily oral pre-exposure prophylaxis among men who have sex with men and transgender women, suburban Yangon, Myanmar
Uptake and challenges with daily oral pre-exposure prophylaxis among men who have sex with men and transgender women, suburban Yangon, Myanmar Open
Background Pre-exposure prophylaxis (PrEP) is effective for human immunodeficiency virus (HIV) prevention in risk groups. We assessed PrEP uptake and 12-month retention among men who have sex with men (MSM) and transgender women (TGW) in M…
View article: Effect of screening for Neisseria gonorrhoeae and Chlamydia trachomatis on incidence of these infections in men who have sex with men and transgender women taking HIV pre-exposure prophylaxis (the Gonoscreen study): results from a randomised, multicentre, controlled trial
Effect of screening for Neisseria gonorrhoeae and Chlamydia trachomatis on incidence of these infections in men who have sex with men and transgender women taking HIV pre-exposure prophylaxis (the Gonoscreen study): results from a randomised, multicentre, controlled trial Open
View article: <i>Rhodococcus equi</i>, an Unusual Human Pathogen That Causes Cavitating Pneumonia in Patients With AIDS
<i>Rhodococcus equi</i>, an Unusual Human Pathogen That Causes Cavitating Pneumonia in Patients With AIDS Open
Rhodococcus equi is a rare human opportunistic pathogen that has been increasingly reported in recent decades. It mainly affects immunosuppressed patients, and in particular human immunodeficiency virus (HIV)–infected patients, where it ty…
View article: Failure of artemether-lumefantrine therapy in travellers returning to Belgium with <i>Plasmodium falciparum</i> malaria: an observational case series with genomic analysis
Failure of artemether-lumefantrine therapy in travellers returning to Belgium with <i>Plasmodium falciparum</i> malaria: an observational case series with genomic analysis Open
Background Failure of artemisinin-based combination therapy is increasingly reported in patients with Plasmodium falciparum malaria in sub-Saharan Africa. We aimed to describe the clinical and genomic characteristics of recent cases of P. …
View article: Phylogenetic Analysis of Hepatitis C Virus Infections in a Large Belgian Cohort Using Next-Generation Sequencing of Full-Length Genomes
Phylogenetic Analysis of Hepatitis C Virus Infections in a Large Belgian Cohort Using Next-Generation Sequencing of Full-Length Genomes Open
The hepatitis C virus (HCV) epidemic in Western countries is primarily perpetuated by the sub-populations of men who have sex with men (MSM) and people who inject drugs (PWID). Understanding the dynamics of transmission in these communitie…
View article: A truncated HIV Tat demonstrates potent and specific latency reversal activity
A truncated HIV Tat demonstrates potent and specific latency reversal activity Open
A major barrier to HIV-1 cure is caused by the pool of latently infected CD4 T-cells that persist under combination antiretroviral therapy (cART). This latent reservoir is capable of producing replication-competent infectious viruses once …
View article: Systematic review on cumulative HIV viraemia among people living with HIV receiving antiretroviral treatment and its association with mortality and morbidity
Systematic review on cumulative HIV viraemia among people living with HIV receiving antiretroviral treatment and its association with mortality and morbidity Open
Background We performed a systematic review to generate evidence on the association between cumulative human immunodeficiency virus (HIV) viraemia and health outcomes. Methods Quantitative studies reporting on HIV cumulative viraemia (CV) …
View article: Effect on the Resistome of Dual vs Monotherapy for the Treatment of <i>Neisseria gonorrhoeae</i>: Results From a Randomized Controlled Trial (ResistAZM Trial)
Effect on the Resistome of Dual vs Monotherapy for the Treatment of <i>Neisseria gonorrhoeae</i>: Results From a Randomized Controlled Trial (ResistAZM Trial) Open
Background No randomized controlled trial (RCT) has compared the impact on the resistome of ceftriaxone (CRO) plus azithromycin (AZM) vs CRO for the treatment of Neisseria gonorrhoea (NG). Methods This was an open-label, single-center, RCT…
View article: Does screening for<i>Neisseria gonorrhoeae</i>and<i>Chlamydia trachomatis</i>affect the incidence of these infections in men who have sex with men taking HIV pre-exposure prophylaxis (PrEP)Results from a randomized, multicentre controlled trial (the Gonoscreen study)
Does screening for<i>Neisseria gonorrhoeae</i>and<i>Chlamydia trachomatis</i>affect the incidence of these infections in men who have sex with men taking HIV pre-exposure prophylaxis (PrEP)Results from a randomized, multicentre controlled trial (the Gonoscreen study) Open
Summary Background Guidelines recommend three-site (urine, anal, pharynx) three-monthly (3X3 screening) screening for Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) in men who have sex with men (MSM) taking HIV pre-exposure prop…
View article: Long-term effects on subclinical cardiovascular disease of switching from boosted protease inhibitors to dolutegravir
Long-term effects on subclinical cardiovascular disease of switching from boosted protease inhibitors to dolutegravir Open
Background In the NEAT022 trial, switching from boosted PIs (PI/r) to dolutegravir in people with HIV (PWH) with high cardiovascular risk decreased plasma lipids, soluble CD14 and adiponectin, and showed consistent favourable, although non…
View article: Incidence of Hypertension and Blood Pressure Changes in Persons With Human Immunodeficiency Virus at High Risk for Cardiovascular Disease Switching From Boosted Protease Inhibitors to Dolutegravir: A Post-hoc Analysis of the 96-week Randomised NEAT-022 Trial
Incidence of Hypertension and Blood Pressure Changes in Persons With Human Immunodeficiency Virus at High Risk for Cardiovascular Disease Switching From Boosted Protease Inhibitors to Dolutegravir: A Post-hoc Analysis of the 96-week Randomised NEAT-022 Trial Open
Background Integrase inhibitors have been recently linked to a higher risk for hypertension. In NEAT022 randomized trial, virologically suppressed persons with human immunodeficiency virus (HIV, PWH) with high cardiovascular risk switched …
View article: Drug behaviors, sexually transmitted infection prevention, and sexual consent during chemsex: insights generated in the Budd app after each chemsex session
Drug behaviors, sexually transmitted infection prevention, and sexual consent during chemsex: insights generated in the Budd app after each chemsex session Open
Chemsex refers to the intentional use of drugs before or during sex in a specific context, typically involving prolonged sex sessions with multiple partners. Engaging in chemsex is associated with a wide range of health risks and related r…
View article: Efficacy, durability, and tolerability of bictegravir/emtricitabine/tenofovir alafenamide for the treatment of <scp>HIV</scp> in a real‐world setting in Belgium
Efficacy, durability, and tolerability of bictegravir/emtricitabine/tenofovir alafenamide for the treatment of <span>HIV</span> in a real‐world setting in Belgium Open
Objectives Our objective was to evaluate the efficacy, durability, and tolerability of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) in a real‐world setting in Belgium. Methods This was a retrospective, multicentre cohort s…
View article: A truncated HIV Tat demonstrates potent and specific latency reversal activity
A truncated HIV Tat demonstrates potent and specific latency reversal activity Open
A major barrier to HIV-1 cure is caused by the pool of latently infected CD4 T-cells that persist under combination antiretroviral therapy (cART). This latent reservoir is capable of producing replication-competent infectious virus once pr…
View article: Long-Term Benefits from Early Antiretroviral Therapy Initiation in HIV Infection
Long-Term Benefits from Early Antiretroviral Therapy Initiation in HIV Infection Open
Among adults with CD4+ counts >500 cells/mm3, excess risk of AIDS and SNA associated with delaying treatment initiation was diminished after ART initiation, but persistent excess risk remained. (Funded by the National…
View article: Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak
Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak Open
View article: The Impact of Analytical Treatment Interruptions and Trial Interventions on Time to Viral Re-Suppression in People Living with HIV Restarting ART in Cure-Related Clinical Studies: A Systematic Review and Meta-Analysis
The Impact of Analytical Treatment Interruptions and Trial Interventions on Time to Viral Re-Suppression in People Living with HIV Restarting ART in Cure-Related Clinical Studies: A Systematic Review and Meta-Analysis Open
View article: Alternative sampling specimens for the molecular detection of mpox (formerly monkeypox) virus
Alternative sampling specimens for the molecular detection of mpox (formerly monkeypox) virus Open
View article: Self-control for harm reduction in chemsex
Self-control for harm reduction in chemsex Open