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View article: Mucin 4 expression is associated with metastasis in triple-negative breast cancer and can be tackled by soluble TNF blockade, improving immunotherapy outcome
Mucin 4 expression is associated with metastasis in triple-negative breast cancer and can be tackled by soluble TNF blockade, improving immunotherapy outcome Open
View article: Cancer immune exclusion: breaking the barricade for a successful immunotherapy
Cancer immune exclusion: breaking the barricade for a successful immunotherapy Open
Immunotherapy has changed the course of cancer treatment. The initial steps were made through tumor-specific antibodies that guided the setup of an antitumor immune response. A new and successful generation of antibodies are designed to ta…
View article: Emerging Targeted Therapies for HER2-Positive Breast Cancer
Emerging Targeted Therapies for HER2-Positive Breast Cancer Open
Breast cancer is the most common cancer in women and the leading cause of death. HER2 overexpression is found in approximately 20% of breast cancers and is associated with a poor prognosis and a shorter overall survival. Tratuzumab, a mono…
View article: Blocking soluble TNFα sensitizes HER2-positive breast cancer to trastuzumab through MUC4 downregulation and subverts immunosuppression
Blocking soluble TNFα sensitizes HER2-positive breast cancer to trastuzumab through MUC4 downregulation and subverts immunosuppression Open
Background The success of HER2-positive (HER2+) breast cancer treatment with trastuzumab, an antibody that targets HER2, relies on immune response. We demonstrated that TNFα induces mucin 4 (MUC4) expression, which shields the trastuzumab …
View article: 877 Blocking soluble TNFα sensitizes HER2-positive breast cancer to trastuzumab through MUC4 downregulation and subverts immunosuppression
877 Blocking soluble TNFα sensitizes HER2-positive breast cancer to trastuzumab through MUC4 downregulation and subverts immunosuppression Open
Background Trastuzumab resistance is an important clinical issue. Although a plethora of resistance mechanisms have been characterized, few have been shown to be actionable. We have demonstrated that soluble TNFα isoform (sTNFα) upregulate…
View article: ODP438 Canonical and Non-canonical Function of EZH2 in Progesterone Receptor Target Genes in Breast Cancer
ODP438 Canonical and Non-canonical Function of EZH2 in Progesterone Receptor Target Genes in Breast Cancer Open
Enhancer of Zeste homolog 2 (EZH2) is a histone methyltransferase which catalyzes the trimethylation of lysine 27 of histone H3 (H3K27me3), an epigenetic mark associated with chromatin compaction and transcriptional repression of target ge…
View article: El laboratorio bioquímico en los desórdenes óseos esclerosantes: Creatinquinasa y osteopetrosis
El laboratorio bioquímico en los desórdenes óseos esclerosantes: Creatinquinasa y osteopetrosis Open
Introducción: la osteopetrosis (enfermedad de huesos de mármol) es un raro tipo de displasia ósea esclerosante caracterizada por una alteración en el funcionamiento / morfología del osteoclasto, lo que conduce a un defecto en la resorción …
View article: Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy
Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy Open
Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine known to have contradictory roles in oncoimmunology. Indeed, TNFα has a central role in the onset of the immune response, inducing both activation and the effector function of ma…
View article: Relevance of Early Diagnosis in Reactivated Acute Nervous Form of Chagas Disease: Importance of Cytology in Cerebrospinal Fluid
Relevance of Early Diagnosis in Reactivated Acute Nervous Form of Chagas Disease: Importance of Cytology in Cerebrospinal Fluid Open
The presence of trypomastigote Trypanosoma cruzi (T. cruzi) was detected in the cerebrospinal fluid (CSF) of an immunosuppressed patient, due to AIDS, and diagnosed as reactivated acute nervous form of Chagas disease. We consider the i…
View article: Relevance of Early Diagnosis in Reactivated Acute Nervous Form of Chagas Disease: Importance of Cytology in Cerebrospinal Fluid
Relevance of Early Diagnosis in Reactivated Acute Nervous Form of Chagas Disease: Importance of Cytology in Cerebrospinal Fluid Open
The presence of trypomastigote Trypanosoma cruzi (T. cruzi) was detected in the cerebrospinal fluid (CSF) of an immunosuppressed patient, due to AIDS, and diagnosed as reactivated acute nervous form of Chagas disease. We consider the impor…